Multi-Targeted Molecular Effects of Hibiscus sabdariffa Polyphenols: An Opportunity for a Global Approach to Obesity.

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orlistat 2 endocrinologydiseasesdrugs
hyperlipidemia 1 endocrinologydiseases
metabolic syndrome 4 endocrinologydiseases
obesity 40 endocrinologydiseases

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orlistat 19756 obesity-related metabolic disorders in a similar manner to current digestion inhibitory drugs such as orlistat , which is also associated with triglyceride reductions and adiponectin activation [[68]]. Although these
orlistat 22321 two sites in the lipase/colipase complex are shown in Figure 2B and compared to the drug inhibitor orlistat . As mentioned in the case of intestinal glucosidases, the majority of the HS compounds exhibited lower
Select Disease Character Offset Disease Term Instance
hyperlipidemia 29495 hyperammonemic rats. In addition, several studies in animal models of metabolic syndrome, diabetes or hyperlipidemia have reported an increase in the expression of SOD, CAT, GPx and GR (Figure 3) in several tissues, such
metabolic syndrome 2861 sedentary lifestyle are consistent with the appearance of several metabolic dysfunctions leading to metabolic syndrome (MetS). MetS is a clustering of cardio-metabolic risk factors, including abdominal obesity, insulin
metabolic syndrome 29463 glutathione (GSH) in brain tissues of hyperammonemic rats. In addition, several studies in animal models of metabolic syndrome , diabetes or hyperlipidemia have reported an increase in the expression of SOD, CAT, GPx and GR (Figure
metabolic syndrome 33615 several authors. Joven et al. demonstrated that HS extracts lowered blood pressure in human patients with metabolic syndrome and improved the endothelial function in a rat model. In this study, the consumption of 125 mg/kg/day
metabolic syndrome 35928 an interesting approach to ameliorate and/or prevent other chronic inflammatory diseases related to metabolic syndrome such as atherosclerosis, steatohepatitis or cardiovascular diseases.6.3. Modulation of Energy Metabolism
obesity 1372 equation and changing metabolic and oxidative stress biomarkers, which can result in the development of obesity -related metabolic disorders. The pleiotropic effects of dietary plant polyphenols are capable of counteracting
obesity 1672 epigenetic modifications. Hibiscus sabdariffa (HS)-derived polyphenols are known to ameliorate various obesity -related conditions. Recent evidence leads to propose the complex nature of the underlying mechanism
obesity 2080 well as epigenetic modifications. This article reviews the accumulated evidence on the multiple anti- obesity effects of HS polyphenols in cell and animal models, as well as in humans, and its putative molecular
obesity 2710 well as their possible implications in the design of safe and effective polyphenolic formulations for obesity . 1. IntroductionDiet-induced obesity and a sedentary lifestyle are consistent with the appearance of
obesity 2747 the design of safe and effective polyphenolic formulations for obesity. 1. IntroductionDiet-induced obesity and a sedentary lifestyle are consistent with the appearance of several metabolic dysfunctions leading
obesity 2963 metabolic syndrome (MetS). MetS is a clustering of cardio-metabolic risk factors, including abdominal obesity , insulin resistance, dyslipidemia and hypertension [[1],[2]]. Although considerable progress has been
obesity 3131 [[1],[2]]. Although considerable progress has been made in understanding the molecular mechanisms underlying obesity , in many cases its treatment results in failure [[3]]. In this respect, caloric restriction and physical
obesity 3525 as it implicates important changes in the individualĀ“s lifestyle [[4],[5]]. Likewise, current anti- obesity pharmacological treatments are in many cases inefficient, and often present important side effects when
obesity 3805 researchers and clinicians have drawn their attention towards more traditional methods to correct the obesity -induced energy imbalance. Accordingly, the use of metabolic drugs or natural dietary products, including
obesity 4038 xenohormetins, are some of the most interesting and promising strategies in forthcoming studies addressing obesity [[9],[10]]. Exploring the effects of polyphenols on specific cellular pathways and diseases may turn
obesity 4392 polyphenols, a plausible consequence of their molecular diversity, offers a new opportunity to address obesity [[11],[12],[13],[14],[15],[16]]. To this end, the main objective of this review is to elucidate the
obesity 4666 (Malvaceae) polyphenols and provide an overview of their role in the prevention of chronic diseases such as obesity .In this review, we have collected all the relevant evidence regarding the possible benefits of polyphenolic
obesity 4836 regarding the possible benefits of polyphenolic extracts derived from HS calyces on the management of obesity -related pathologies [[17],[18],[19],[20],[21],[22]]. These studies include the use of cell and animal
obesity 4946 obesity-related pathologies [[17],[18],[19],[20],[21],[22]]. These studies include the use of cell and animal obesity models, as well as human clinical trials. Furthermore, the complete characterization of this plant extract,
obesity 5428 the proper use of HS polyphenols may present an opportunity to improve the control or prevention of obesity -related diseases through the modulation of key proteins involved in oxidative stress and inflammation
obesity 5971 [[21],[23],[24]]. This hypothesis suggests that the active manipulation of energy sensors and effectors in obesity might be a feasible preventive therapy. Nevertheless, further research is necessary in order to delimit
obesity 6468 targets, as well as to identify endogenous metabolite biomarkers. From this perspective, validated obesity -related biomarkers could provide new diagnostic tools and establish key insights concerning the effects
obesity 13643 design suitable and novel approaches for diseases with complex pathogenic mechanisms [[36]], such as obesity -related complications.Several studies have postulated on the putative synergistic effect of mixed botanical
obesity 18506 HS polyphenols with digestive enzymes as their putative molecular targets to explain their effect on obesity . Polyphenols are capable of interacting with proteins through hydrophobic or hydrophilic interactions,
obesity 19654 that proposed by Hansawasdi et al. Thus, continuous administration of HS polyphenols might improve obesity -related metabolic disorders in a similar manner to current digestion inhibitory drugs such as orlistat,
obesity 23398 health [[16]]. To this end, botanical polyphenols could be used as possible therapeutic sources to treat obesity . Oxidative stress is implicated in the development of many chronic conditions, including obesity. This
obesity 23495 treat obesity. Oxidative stress is implicated in the development of many chronic conditions, including obesity . This is due to an imbalance between excess reactive oxygen species (ROS) and the inability of the intracellular
obesity 25012 overexpression is associated with various neurological diseases and cancers [[74]].A correlation exists between obesity and oxidative stress, as a chronic inflammatory process has been detected in the adipose tissue of obese
obesity 26131 [[77]].Various studies have indicated a possible role for HS polyphenols in regulating excess ROS in obesity -related disorders. For example, HS aqueous extracts have shown a higher capability to scavenge peroxyl
obesity 27223 finding a suitable combination of bioactive HS polyphenols could represent an opportunity to ameliorate obesity -associated oxidative stress.A correlation between the total phenolic content of HS extracts and their
obesity 31436 oxidative stress are closely related and interdependent processes that contribute to the pathogenesis of obesity -associated diseases [[92]].The anti-inflammatory activity of HS polyphenols has been previously reported
obesity 35780 mechanisms of action of HS polyphenols (Figure 4). Thus, regulation of the inflammatory processes in obesity through HS extract consumption could be an interesting approach to ameliorate and/or prevent other chronic
obesity 36807 antioxidant capability and protect against chronic inflammation, which have been positively correlated to obesity -related metabolic disorders [[48],[98]]. Nevertheless, these pathologies are complex conditions that
obesity 37935 responsible for the lower lipid accumulation, indicating that it may be a suitable strategy to improve obesity -associated disturbances. Several studies have proven the ability of HS polyphenols to help reduce body
obesity 42280 effects observed in synthetic agonists, has been postulated as an opportunity for the management of obesity [[69]]. In fact, some polyphenols such as resveratrol [[105]] or scutellarin [[106]] have shown experimentally
obesity 43446 on specific molecular targets in order to explain their molecular mechanism in the amelioration of obesity -related pathologies. As such, several cellular pathways, transcription factors and enzymatic activities
obesity 46150 have indicated that HS polyphenols are capable of targeting several proteins that are implicated in obesity -associated metabolic disorders, i.e. AMPK, PPAR and FASN. In order to elucidate on the possibility that
obesity 50720 characterized by early cellular events and dysregulation of normal cellular homeostasis. In this sense, obesity must be understood as a multidimensional disease, ranging from adipocyte hypertrophy to the appearance
obesity 51358 and SOD, among others, have been proposed by several authors as specific targets in the treatment of obesity -associated metabolic disorders. In this scenario, HS polyphenols seem to interact with all the above-mentioned
obesity 51665 granted to this plant.Among the putative processes involved in the molecular effects of HS polyphenols on obesity are: modulation of the signaling and energy metabolism pathways, regulation of redox homeostasis and
obesity 52020 other aspects.The extensive literature on the multiple beneficial effects that HS extract exert on obesity -related diseases, as well as its putative mechanism of action, provides sufficient evidence to conclude
obesity 52475 required to define the adequate dosage for therapy as well as validate its use in the management of obesity [[116]]. Therefore, future research should pay attention to identify the cellular metabolites of HS
obesity 53645 superiority of the combination of polyphenols in HS extract with respect to their individual components for obesity -related pathologies seems to be demonstrated, several issues related to bioavailability, dosage and
obesity 55128 polyphenols. On the contrary, to fully understand the health and multi-target effects that polyphenols have on obesity and human health, it is necessary to integrate transcriptomic, proteomic and targeted metabolomic approaches,
obesity 55695 will be able to succeed in the design of polyphenolic mixtures sufficiently effective to ameliorate obesity -related pathologies through nutritional intervention or pharmacological treatment.Figure 1Chemical structures

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