Moxibustion treatment for primary osteoporosis: A systematic review of randomized controlled trials.

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calcitriol 14814 training;5 Calcium supplementation and alendronate sodium;6 Calcium supplementation, alendronate sodium and calcitriol .Moxibustion included heat-sensitive moxibustion (5 trials), mild moxibustion (4 trials), du-moxibustion
calcitriol 17452 supplementation and alendronate sodium [[41], [42]], calcium supplementation, alendronate sodium and calcitriol [[43]]. However, the type of study design such as moxibustion vs. no treatment or waiting-list was not
calcitriol 22597 -1.14), flexion-extension pain (MD -1.34, 95%CI -1.69 to -0.99) when calcium D, alendronate sodium and calcitriol were applied as basic treatment [[43]].Functional activities assessmentOnly one trial observed functional
calcitriol 35046 anti-osteoporosis medications to choose, for instance, calcium supplementation, alendronate sodium or calcitriol .Implications for the future researchWith ever-growing interest in complementary and alternative treatments
Select Disease Character Offset Disease Term Instance
osteoporosis 49 Title: PLoS ONEMoxibustion treatment for primary osteoporosis : A systematic review of randomized controlled trialsAlternative Title: Moxibustion treatment for primary
osteoporosis 167 systematic review of randomized controlled trialsAlternative Title: Moxibustion treatment for primary osteoporosis Fanping XuMinghua HuangYi JinQingzhe KongZhongmin LeiXu Wei [1]Department of Orthopaedics, Beijing Hospital
osteoporosis 628 University, CHINAPublication date (epub): 6/2017Publication date (collection): /2017AbstractPrimary osteoporosis (POP) has a serious impact on quality of life for middle-aged and elderly, which particularly increase
osteoporosis 1173 enrolled. The outcomes might be fracture incidence, quality of life, clinical symptoms, death attributed to osteoporosis , adverse effect, bone mineral density (BMD), and biochemical indicators. Literature selection, data
osteoporosis 1582 obvious clinical or statistical heterogeneity. Limited evidence suggested that moxibustion plus anti- osteoporosis medicine might be more effective in relieving the pain (visual analogue scale scores average changed
osteoporosis 1942 level of bone gla protein, osteoprotegerin and bone alkaline phosphatase (2 trials) compared with anti- osteoporosis medicine alone. However, the quality of previous studies was evaluated as generally poor. The safety
osteoporosis 2516 AvailabilityAll relevant data are within the paper and its Supporting Information files.IntroductionPrimary osteoporosis (POP) is a disease particularly occurred in senile population and postmenopausal women [[1]]. In Asia
osteoporosis 3238 post-discharge, the average direct medical cost, indirect medical cost, and caregiver lost income associated with osteoporosis -related fracture still totaled ¥7,886 [[8]]. Therefore, treatment of osteoporosis has positive significance
osteoporosis 3321 associated with osteoporosis-related fracture still totaled ¥7,886 [[8]]. Therefore, treatment of osteoporosis has positive significance to prevent fractures, especially for POP patients. With a growing number of
osteoporosis 3706 the management of POP gained more and more attention in many nations of the world [[10]–[12]].Anti- osteoporosis medicine is recommended as the first-line treatment for POP in the clinical practice guidelines [[13],
osteoporosis 4241 the clinical doctors and patients are looking for complementary and alternative therapies to treat osteoporosis [[19], [20]]. As a Chinese traditional treatment, moxibustion has been commonly used in several chronic
osteoporosis 6198 conventional therapy with at least one of the outcomes of interest. For instance: moxibustion vs. anti osteoporosis drug, (moxibustion + antiosteoporosis drug) vs. (antiosteoporosis drug), moxibustion vs. no treatment,
osteoporosis 6236 of the outcomes of interest. For instance: moxibustion vs. antiosteoporosis drug, (moxibustion + anti osteoporosis drug) vs. (antiosteoporosis drug), moxibustion vs. no treatment, moxibustion vs. exercise. The outcomes
osteoporosis 6264 For instance: moxibustion vs. antiosteoporosis drug, (moxibustion + antiosteoporosis drug) vs. (anti osteoporosis drug), moxibustion vs. no treatment, moxibustion vs. exercise. The outcomes at the end of treatment
osteoporosis 6562 symptoms (such as pain, muscle fatigue, and limited mobility), death directly or indirectly attributed to osteoporosis , adverse effect, bone mineral density (BMD), and biochemical markers of bone turnover [[28]].Database
osteoporosis 7020 Biomedical Literature Database (CBM) were retrieved. The search terms used were “moxibustion”, “ osteoporosis ”, and “random” from their inception to July 30, 2016. The keywords were combined applying the
osteoporosis 7250 operation AND. The search statement applied in the PubMed database was presented as ((moxibustion) AND osteoporosis ) AND random. The search was restricted to RCTs published in English or Chinese. In addition, we performed
osteoporosis 11637 groups was above 50 years old. According to the classification criteria of disease, POP included senile osteoporosis and postmenopausal osteoporosis [[1]]. In this systematic review, 2 trials paid attention to senile
osteoporosis 11669 According to the classification criteria of disease, POP included senile osteoporosis and postmenopausal osteoporosis [[1]]. In this systematic review, 2 trials paid attention to senile osteoporosis [[30], [33], [34]],
osteoporosis 11750 and postmenopausal osteoporosis [[1]]. In this systematic review, 2 trials paid attention to senile osteoporosis [[30], [33], [34]], 5 trials just studied postmenopausal osteoporosis [[37], [38], [40]–[42]], 6 trials
osteoporosis 11820 trials paid attention to senile osteoporosis [[30], [33], [34]], 5 trials just studied postmenopausal osteoporosis [[37], [38], [40]–[42]], 6 trials focused on both [[31], [32], [35], [36], [39], [43]].10.1371/journal.pone.0178688.t001Table
osteoporosis 14053 classification of the disease was determined according to the clinical practice guideline for primary osteoporosis [[1]];T: treatment group; C: control group; POP: primary osteoporosis; SOP: senile osteoporosis; PMOP:
osteoporosis 14123 practice guideline for primary osteoporosis [[1]];T: treatment group; C: control group; POP: primary osteoporosis ; SOP: senile osteoporosis; PMOP: postmenopausal osteoporosis; BMD: bone mineral density; BGP: bone gla
osteoporosis 14149 primary osteoporosis [[1]];T: treatment group; C: control group; POP: primary osteoporosis; SOP: senile osteoporosis ; PMOP: postmenopausal osteoporosis; BMD: bone mineral density; BGP: bone gla protein; ALP: alkaline
osteoporosis 14184 group; C: control group; POP: primary osteoporosis; SOP: senile osteoporosis; PMOP: postmenopausal osteoporosis ; BMD: bone mineral density; BGP: bone gla protein; ALP: alkaline phosphatase; BALP: bone alkaline phosphatase;
osteoporosis 17812 trials. For the outcome evaluation, fracture incidence and death directly or indirectly attributed to osteoporosis were not reported in all the previous studies. Quality of life [[36], [40]], pain and functional activities
osteoporosis 20945 quality of life [[36], [40]]. The medical outcome study item short form health survey (SF-36) [[36]] and osteoporosis quality of life scale [[40]] were used to evaluate the quality of life, respectively. One trial [[36]]
osteoporosis 22196 other two trials showed positive effect of du-moxibustion plus calcium D treatment for postmenopausal osteoporosis (MD -1.15, 95%CI -1.74 to -0.56) [[38]] or for POP (MD -2.16, 95%CI -2.36 to -1.96) [[39]] compared
osteoporosis 27718 (MD 3.16 pg/ml, 95%CI 0.81 pg/ml to 5.51 pg/ml) [[36]] had a better add-on benefit compared with anti- osteoporosis medicine alone. At the same time, there was no significant difference for serum estradiol (E2) between
osteoporosis 28136 moxibustion as add-on treatment for alendronate sodium (MD -38 U/L, 95%CI -41.46 U/L to -34.54 U/L) in senile osteoporosis patients [[33]]. The other one showed significant effect of mild moxibustion plus calcium D compared
osteoporosis 28332 calcium D compared with calcium D alone (MD 9.16 U/L, 95%CI 4.62 U/L to 13.70 U/L) in postmenopausal osteoporosis patients [[37]]. Meanwhile, heat-sensitive moxibustion plus alendronate sodium could improve the level
osteoporosis 29008 -0.45 U/L to 0.79 U/L) [[40]].Three trials reported blood calcium (Ca) [[41]–[43]]. Based on the anti- osteoporosis medicine therapy, mild moxibustion (MD -1.04 mmol/L, 95%CI -1.77 mmol/L to -0.31 mmol/L) [[41]] and
osteoporosis 30113 0.06 mmol/L, 95%CI -0.23 mmol/L to 0.35 mmol/L) [[41]] had no better add-on benefit compared with anti- osteoporosis medicine alone.Adverse effectTwo of 13 trials observed the adverse drug reaction (ADR) [[31], [38]],
osteoporosis 31069 POP.DiscussionSummary of evidenceMedication and functional exercise remains the mainstay for the treatment of osteoporosis [[44]–[48]]. In the included 13 trials, different type of moxibustion is almost applied as a complementary
osteoporosis 31802 P, ALP, ratio of urinary calcium /Creatinine). Limited evidence suggest that moxibustion plus anti- osteoporosis medicine may be more effective in reducing the pain (VAS scores average changed 2 scores between groups,
osteoporosis 32095 between groups, 3 trials), and improving the level of BGP, OPG and BALP (2 trials) compared with anti- osteoporosis medicine alone. However, all of the trials were assessed to be low quality due to the high risk of bias.One
osteoporosis 34775 patients [[50]].In this review, the preliminary result suggests that moxibustion plus conventional anti- osteoporosis medicine may have better effect on alleviating the pain and increasing the BMD of femoral neck though
osteoporosis 34949 increasing the BMD of femoral neck though the insufficient evidence was seen. There are various anti- osteoporosis medications to choose, for instance, calcium supplementation, alendronate sodium or calcitriol.Implications
osteoporosis 36044 the question if moxibustion plus conventional therapy will affect fracture incidence attributed to osteoporosis , the answer is unknown. As fracture incidence is the endpoint outcome of POP, the long-term follow up

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