Early-Life Obesity Prevention: Critique of Intervention Trials During the First One Thousand Days.

Existing Reviews

Please note, new claims can take a short while to show up.

No claims yet.

Annotation Summary

Term Occurence Count Dictionary
obesity 46 endocrinologydiseases
childhood obesity 7 endocrinologydiseases

There are not enough annotations found in this document to create the proximity graph.

Review

Having read the paper, please pick a pair of statements from the paper to indicate that a drug and disease are related.

Select Drug Character Offset Drug Term Instance
Select Disease Character Offset Disease Term Instance
childhood obesity 3654 times in development. There is now a substantial literature on early-life behavioral risk factors for childhood obesity , summarized and synthesized in recent systematic reviews. Monasta et al. [[]] concluded that there was
childhood obesity 6331 study outcome measures?MethodsSince the present review aimed to critique the evidence on early-life childhood obesity prevention interventions, it was important that the critique was applied to a recent and comprehensive
childhood obesity 11971 behavior and infant sleep in the other), not all of which were well-established as risk factors for childhood obesity . None of the trials appear to have targeted maternal smoking. The evidence base from completed pregnancy-infancy
childhood obesity 18763 in pediatric clinical intervention trials [[]]. Our recent longitudinal studies on the etiology of childhood obesity have been able to identify associations with exposures, such as sedentary behavior, when we have used
childhood obesity 19128 z-score) in the same analyses [[]]. Finally, our systematic review on physical activity in the etiology of childhood obesity found that associations between physical activity-adiposity (and effects of physical activity on adiposity
childhood obesity 22987 work/the long-term nature of funding required. Nonetheless, the current and future global burden of childhood obesity warrants an effort of this kind [[]•, []].A major new research project coordinated by WHO, starting
childhood obesity 26504 possible, be more global with a much greater emphasis on populations in low-middle-income countries where childhood obesity is now prevalent, be careful to map intervention targets on to the behavioral risk factor evidence,
obesity 343 4/2017Publication date (ppub): /2017AbstractPurpose of ReviewTo critique the evidence from recent and ongoing obesity prevention interventions in the first 1000 days in order to identify evidence gaps and weaknesses,
obesity 1109 behavioral risk factors (maternal smoking during pregnancy, infant and child sleep). Finally, while obesity prevention interventions aim to modify body composition, few intervention trials have used body composition
obesity 1439 Lifestyles Trajectory (HeLTI) initiative should address some of these weaknesses.SummaryFuture early obesity prevention trials should be much more ambitious. They should, ideally: extend their interventions over
obesity 1826 BMI for age); have greater emphasis on maternal smoking and child sleep; be global.IntroductionAs the obesity pandemic has evolved, research efforts aimed at addressing it have increasingly focused on the opportunities
obesity 2238 i.e., equivalent to the “first 1000 days” of life. This trend towards an emphasis on early-life obesity prevention was expressed in the recent Ending Childhood Obesity Report [[]•] which highlighted the
obesity 2518 pre-conception, pregnancy, infancy, and early childhood. Figure 1a demonstrates the rapidly increasing numbers of obesity prevention interventions in early life, as revealed by systematic reviews [[]•, []–[]] published
obesity 2667 as revealed by systematic reviews [[]•, []–[]] published between 2002 and 2016.Fig. 1a Number of obesity prevention interventions in early life (first 1000 days) identified by successive systematic reviews.
obesity 2892 completed and ongoing early-life interventions by geographical region [[]•]. c Number of early-life obesity prevention interventions by life-course stages [[]•]. d Number of early-life obesity prevention studies
obesity 2979 of early-life obesity prevention interventions by life-course stages [[]•]. d Number of early-life obesity prevention studies reporting body composition (body fatness) outcomes [[]•]Two fundamental arguments
obesity 3390 behavior change, such as rapid infant growth) in early life substantially increase the risk of later obesity through establishing lifestyle habits which are obesogenic, and/or by “programming” of biological
obesity 3664 development. There is now a substantial literature on early-life behavioral risk factors for childhood obesity , summarized and synthesized in recent systematic reviews. Monasta et al. [[]] concluded that there was
obesity 3927 factors: maternal diabetes; maternal smoking; rapid infant growth; no or limited breastfeeding; infant obesity ; low physical activity in early childhood; short sleep duration in early childhood; and sugar-sweetened
obesity 4799 for preventive intervention in early life lies in the increasing concern over social inequalities in obesity —the generally higher risk of obesity with lower socio-economic (SES) in high-income countries [[],
obesity 4838 life lies in the increasing concern over social inequalities in obesity—the generally higher risk of obesity with lower socio-economic (SES) in high-income countries [[], []]. These social inequalities are already
obesity 5147 body of evidence suggests that targeting the well-established early-life behavioral risk factors for obesity (many of which are markedly socially patterned) may be particularly effective for reducing social inequalities
obesity 5269 are markedly socially patterned) may be particularly effective for reducing social inequalities in obesity [[]•].While early-life prevention of obesity is increasingly important to researchers [[]•], it
obesity 5316 particularly effective for reducing social inequalities in obesity [[]•].While early-life prevention of obesity is increasingly important to researchers [[]•], it is a relatively new concept to many outside the
obesity 5435 increasingly important to researchers [[]•], it is a relatively new concept to many outside the pediatric obesity research community. There remains a good deal of uncertainty as to how best to turn the principles of
obesity 5854 evidence-based answers to the following research questions:Where, geographically, have the early-life obesity prevention interventions taken place?;Which life-course stages have research interventions focused on?;Which
obesity 6341 outcome measures?MethodsSince the present review aimed to critique the evidence on early-life childhood obesity prevention interventions, it was important that the critique was applied to a recent and comprehensive
obesity 6573 evidence. The 2016 systematic review by Blake-Lamb et al. [[]•] on interventions for prevention of obesity in the first 1000 days of life was identified as a very good basis for the present critique. The Blake-Lamb
obesity 7338 QuestionsQuestion 1: Where, Geographically, Have Early-Life Obesity Prevention Interventions Taken Place?While obesity is pandemic, and is placing a large and rapidly increasing burden on low-middle-income countries [[]•,
obesity 7470 placing a large and rapidly increasing burden on low-middle-income countries [[]•, []] the early-life obesity prevention intervention studies reviewed to date are far from global. Figure 1b illustrates the extent
obesity 8495 Stages Have Been Targeted in Early-Life Obesity Prevention Interventions?While early-life prevention of obesity encompasses any or all of the four potential life-course stages (pre-conception; pregnancy; infancy;
obesity 9739 postnatal life. As noted above, multiple well-established and modifiable behavioral risk factors for obesity prevention exist during these “neglected” life-course stages (e.g., pre-pregnancy overweight and
obesity 9848 prevention exist during these “neglected” life-course stages (e.g., pre-pregnancy overweight and obesity ; maternal smoking pre-pregnancy or during pregnancy; early childhood sleep, physical activity, and sugar-sweetened
obesity 10194 Interventions, and Which Have Been Neglected?Many well-established and modifiable early-life risk factors for obesity have been identified [[], []]. In this section, we consider the extent to which the evidence of behavioral
obesity 11469 across both pregnancy and infancy, 2 focused on targets not firmly established as risk factors for obesity (probiotics to alter infant gut microbiota; essential fatty acid supplementation); 2 focused on diet
obesity 11981 and infant sleep in the other), not all of which were well-established as risk factors for childhood obesity . None of the trials appear to have targeted maternal smoking. The evidence base from completed pregnancy-infancy
obesity 17666 that of breast milk [[]]. This trial was notable for providing evidence of both long-term effects on obesity as an outcome, and for demonstrating effects which were more substantial than the other trials: increased
obesity 17788 and for demonstrating effects which were more substantial than the other trials: increased risk of obesity at age 6 years in the higher protein formula group (adjusted odds ratio 2.43, CI 1.12 to 5.27) [[]].Question
obesity 18773 pediatric clinical intervention trials [[]]. Our recent longitudinal studies on the etiology of childhood obesity have been able to identify associations with exposures, such as sedentary behavior, when we have used
obesity 19138 same analyses [[]]. Finally, our systematic review on physical activity in the etiology of childhood obesity found that associations between physical activity-adiposity (and effects of physical activity on adiposity
obesity 20175 component” model measure [[]]. Multi-component measures are not practical for large field studies in obesity prevention. However, total body water measurement with stable isotope dilution is a highly accurate
obesity 20619 [[]].The above critique of BMI-for-age as an outcome measure does not negate its value as a simple obesity screening tool for clinical use, and for population surveillance of obesity. Systematic reviews have
obesity 20695 negate its value as a simple obesity screening tool for clinical use, and for population surveillance of obesity . Systematic reviews have established that it has high specificity for identifying the fattest children
obesity 21204 critique was based on a very recent and highly relevant systematic review of interventions to prevent obesity in the first 1000 days [[]•], and so our research questions have answers which are both current and
obesity 21464 critique are the quantification of a number of substantial gaps in the evidence on interventions for obesity prevention during the “first 1000 days”, and the identification of mismatches between the behavioral
obesity 22997 long-term nature of funding required. Nonetheless, the current and future global burden of childhood obesity warrants an effort of this kind [[]•, []].A major new research project coordinated by WHO, starting
obesity 23754 able to test the hypothesis suggested by the present critique that achieving a substantial impact on obesity prevention in early life will require modifications to multiple behavioral risk factors, extending over
obesity 24453 high-income western countries, commonly have strongly held views about the early behavioral risk factors for obesity which are at odds with the evidence. For example, mothers and health visitors (community nurses with
obesity 24737 English study reported the following strongly held views: infancy was “too early” to intervene for obesity prevention, and there was considerable potential for harm in doing so; infant crying was always a signal
obesity 24997 [[]]. Clearly, research and policy interventions must address such strong cultural barriers to early obesity prevention. Stressing the minimal potential for harm and the substantial potential benefit of targeting
obesity 25420 reiterating the low risk and many important co-benefits to the main behavioral changes required for obesity prevention: maternal smoking cessation/reduction; adequate maternal physical activity and healthy body
obesity 26362 course highlighted by the present critique.ConclusionsFuture research interventions aiming to prevent obesity in early life should, where possible, be more global with a much greater emphasis on populations in
obesity 26514 more global with a much greater emphasis on populations in low-middle-income countries where childhood obesity is now prevalent, be careful to map intervention targets on to the behavioral risk factor evidence,

You must be authorized to submit a review.