Arsenic Exposure and Type 2 Diabetes: MicroRNAs as Mechanistic Links?

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Annotation Summary

Term Occurence Count Dictionary
obesity 2 endocrinologydiseases
diabetic ketoacidosis 1 endocrinologydiseases
hyperglycemia 2 endocrinologydiseases
maturity-onset diabetes of the young 1 endocrinologydiseases
metabolic syndrome 1 endocrinologydiseases

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Select Drug Character Offset Drug Term Instance
Select Disease Character Offset Disease Term Instance
diabetic ketoacidosis 8040 long-term complications such as cardiovascular disease, nerve and kidney damage, chronic inflammation, or diabetic ketoacidosis [[]]. Risk factors for T2D include both genetic and environmental variables [[], []]. Over 80 distinct
hyperglycemia 1519 iAs-associated diabetes.IntroductionType 2 diabetes (T2D) is a complex metabolic disorder characterized by hyperglycemia that is generally caused by defects in insulin production, secretion, and/or systemic action. While
hyperglycemia 7796 hypertension [[], []], and recently, T2D [[]].Type 2 diabetes is a complex metabolic disorder characterized by hyperglycemia that is generally caused by defects in insulin production, secretion, and/or systemic action [[]]. T2D
maturity-onset diabetes of the young 19873 Hnf1a and Neurod1 [[]], encoded by two different genes in which specific mutations are known to cause maturity-onset diabetes of the young (MODY) [[]].miR-375 was first shown to suppress GSIS in the MIN6 mouse β-cell-like cell line in part
metabolic syndrome 12886 of action remain unknown, multiple studies support an association between endocrine disruptors and metabolic syndrome [[], []], which may partially explain how chronic exposure to iAs has been associated with pathophysiological
obesity 8401 components such as diet and exercise are very important contributing factors, particularly given that obesity often precedes some forms of T2D, chronic exposures to environmental chemicals are less studied in the
obesity 20618 signaling [[], [], []]. These reports suggested that miR-34a may be an attractive therapeutic target for obesity and related metabolic diseases.Notably, most of these miRNAs have been identified as being responsive

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