Obesity in pregnancy: a novel concept on the roles of adipokines in uterine contractility.

Existing Reviews

Please note, new claims can take a short while to show up.

No claims yet.

Annotation Summary

Term Occurence Count Dictionary
diabetes mellitus 9 endocrinologydiseases
glucose intolerance 1 endocrinologydiseases
hypogonadism 1 endocrinologydiseases
obesity 31 endocrinologydiseases
type 2 diabetes mellitus 4 endocrinologydiseases

There are not enough annotations found in this document to create the proximity graph.

Review

Having read the paper, please pick a pair of statements from the paper to indicate that a drug and disease are related.

Select Drug Character Offset Drug Term Instance
Select Disease Character Offset Disease Term Instance
diabetes mellitus 1210 the dysregulation of leptin, adiponectin, and kisspeptin during pregnancy contributes to gestational diabetes mellitus and pre-eclampsia. A preclinical method for obese pregnancy should be developed to clarify the action
diabetes mellitus 10792 or congenital heart failure ([47]). In later gestation, hypertension, preeclampsia, and gestational diabetes mellitus are clinically observed ([48]). However, several studies demonstrated that gestational weight gain even
diabetes mellitus 11814 rare in gestational obesity ([5],[49]). The long-term childhood implications include obesity, type 2 diabetes mellitus , respiratory tract infections, chronic lung disease, bronchial asthma, and chronic obstructive pulmonary
diabetes mellitus 12223 outcomesPD, PPstillbirthobesityDystociafetal and neonatal deathhypertensionCesarean sectionmacrosomiatype 2 diabetes mellitus Gestational diabetes mellitusfetal growth restrictionrespiratory tract infectionHypertensioncongenital
diabetes mellitus 12252 PPstillbirthobesityDystociafetal and neonatal deathhypertensionCesarean sectionmacrosomiatype 2 diabetes mellitusGestational diabetes mellitus fetal growth restrictionrespiratory tract infectionHypertensioncongenital abnormalitiesbronchial asthmaEclampsiaCOPD*Abbreviations:
diabetes mellitus 14070 suggest that the dysregulation of leptin, adiponectin, and kisspeptin during pregnancy contributes to diabetes mellitus and pre-eclampsia ([54]). In addition, obesity was demonstrated to be accompanied by the decreased level
diabetes mellitus 16774 coronary artery disease ([66]). Decreased adiponectin level is responsible for the development of type 2 diabetes mellitus . The adiponectin level decreases progressively during normal pregnancies, probably in response to reduced
diabetes mellitus 17013 sensitivity, and a higher degree of decrease can be detected in pregnant women with obesity or gestational diabetes mellitus ([67]). Although the signaling pathway of adiponectin (AMPK) has been identified as a mechanism important
diabetes mellitus 18440 Kisspeptin as a neuropeptide is also produced by adipose tissue ([73]). Mice models of obesity and type 2 diabetes mellitus revealed increased hepatic kisspeptin expression and kisspeptin plasma levels. Human liver samples from
glucose intolerance 1030 chemokines, and there are no reliable data available describing the relation between body mass index, glucose intolerance , and adipokines during pregnancy. Recent data suggest that the dysregulation of leptin, adiponectin,
hypogonadism 17554 kisspeptin receptor (KISS1R). The deficiency of kisspeptin can lead to idiopathic hypogonadotropic hypogonadism with low level of sexual steroids and gonadotropin hormones, as kisspeptin modifies the secretion of
obesity 697 adrenergic system, oxytocin, and prostaglandins. However, we have limited information about the impact of obesity on the pregnant uterine contractility and gestation time. Adipose tissue, which is the largest endocrine
obesity 845 and gestation time. Adipose tissue, which is the largest endocrine and paracrine organ, especially in obesity , is responsible for the production of adipokines and various cytokines and chemokines, and there are
obesity 1371 obese pregnancy should be developed to clarify the action of adipokines and assess their impact in obesity . The deeper understanding of the adipokines-induced processes in obese pregnancy may be a step closer
obesity 1833 pregnant women and an increasing problem in medical practice ([1],[2]). The most negative consequence of obesity is the development of chronic low-grade metabolic inflammation, which can lead to other pathologic conditions
obesity 3422 0.5% and 10%, and shows great differences among the countries. Paternal genetics, maternal height, obesity , and male fetal gender are among the factors that may have impact on PP ([14]). Although the PP incidence
obesity 4251 old), nonwhite race, and poverty ([13],[16]).The risks factors of PP are not clarified. Recently, the obesity is the only one risk factor of PD that is supposed to be preventable ([17]). The prevention and treatment
obesity 9791 into consideration; therefore, their prolonged use is not recommended ([44]).The impacts of maternal obesity on pregnancyIn contrast to pregnant women of normal weight, insulin resistance is higher in obese pregnant
obesity 11152 However, small for gestational age was also more common in obese pregnancies ([5]). The effect of maternal obesity may also seem contradictory considering the placental weight. It was found that obesity increases placental
obesity 11240 of maternal obesity may also seem contradictory considering the placental weight. It was found that obesity increases placental weight and hypertrophy and this is positively correlated with birth weight ([50],[51]).
obesity 11733 breast-feeding difficulty, postpartum depression, and infections. However, infection is very rare in gestational obesity ([5],[49]). The long-term childhood implications include obesity, type 2 diabetes mellitus, respiratory
obesity 11798 infection is very rare in gestational obesity ([5],[49]). The long-term childhood implications include obesity , type 2 diabetes mellitus, respiratory tract infections, chronic lung disease, bronchial asthma, and
obesity 11993 bronchial asthma, and chronic obstructive pulmonary disease ([52]). There are many consequences of maternal obesity during pregnancy (Table 2).Table 2Complications of maternal obesity*Maternal complicationsFetal outcomesChildhood
obesity 12061 are many consequences of maternal obesity during pregnancy (Table 2).Table 2Complications of maternal obesity *Maternal complicationsFetal outcomesChildhood outcomesPD, PPstillbirthobesityDystociafetal and neonatal
obesity 12139 2Complications of maternal obesity*Maternal complicationsFetal outcomesChildhood outcomesPD, PPstillbirth obesity Dystociafetal and neonatal deathhypertensionCesarean sectionmacrosomiatype 2 diabetes mellitusGestational
obesity 12642 function during pregnancyAdipose tissue becomes a very significant endocrine and paracrine organ in obesity . It is responsible for the production of adipokines and various cytokines and chemokines. Adipokines
obesity 14127 kisspeptin during pregnancy contributes to diabetes mellitus and pre-eclampsia ([54]). In addition, obesity was demonstrated to be accompanied by the decreased level of adiponectin and the increased expression
obesity 14340 leptin and kisspeptin ([58]); therefore, there is a growing interest in these adipokines concerning obesity and pregnancy.LeptinLeptin, a 16 kDa protein, plays an important role in the regulation of food intake
obesity 16629 muscle ([58],[64],[65]). Contrary to leptin, the serum level of adiponectin is inversely correlated with obesity , hypertension, serum lipids and coronary artery disease ([66]). Decreased adiponectin level is responsible
obesity 16990 reduced insulin sensitivity, and a higher degree of decrease can be detected in pregnant women with obesity or gestational diabetes mellitus ([67]). Although the signaling pathway of adiponectin (AMPK) has been
obesity 18421 ([69],[72]). Kisspeptin as a neuropeptide is also produced by adipose tissue ([73]). Mice models of obesity and type 2 diabetes mellitus revealed increased hepatic kisspeptin expression and kisspeptin plasma
obesity 18863 KISSR1, while Ob-Rb is present in kisspeptin neurons in the hypothalamus ([3]). According to this data, obesity can lead to the overexpression of these adipokines, which can lead to pathophysiological changes.Uterine
obesity 19039 to pathophysiological changes.Uterine contractility in obese womenAccording to our recent knowledge, obesity can lead to both premature birth and increased incidence of cesarean section, while weight gain mainly
obesity 19268 myometrial contractility ([74]). Although there are several studies focusing on the correlation between obesity and the increased prevalence of cesarean section, the exact underlying mechanisms and pathogenesis of
obesity 20076 proteins), but it increased the expression of COX-2, which can lead the poor myometrial contractility during obesity ([77],[78]). The high-fat high-cholesterol diet was also found to increase the expression of the oxytocin
obesity 20270 expression of the oxytocin receptor ([79]), but the existing data are contradictory about the influence of obesity on this receptor ([80]). The high-fat high-cholesterol diet also resulted in elevated plasma progesterone
obesity 20465 plasma progesterone level at term, which may also give an evidence for the poor contractility during obesity ([79]). Decreased cervical ripening was also observed during obesity ([81],[82]). Increased leptin in
obesity 20534 the poor contractility during obesity ([79]). Decreased cervical ripening was also observed during obesity ([81],[82]). Increased leptin in obesity can induce adipose and placental PGE2 release contributing
obesity 20575 ([79]). Decreased cervical ripening was also observed during obesity ([81],[82]). Increased leptin in obesity can induce adipose and placental PGE2 release contributing to inflammatory processes. It also disrupts
obesity 21153 and may influence long-term health of newborns. There is an emerging need to clarify the impacts of obesity and adipose tissue-produced adipokines (leptin, adiponectin, kisspeptin) in pregnancy. A preclinical
obesity 21373 obese pregnancy should be worked out to clarify the action of adipokines and assess their impact in obesity . Meanwhile, a clinical investigation should be launched in parallel to reveal the character and the
obesity 21499 clinical investigation should be launched in parallel to reveal the character and the mechanisms of the obesity -induced alteration in gestation length and myometrial contractility. The deeper understanding of the
type 2 diabetes mellitus 11807 very rare in gestational obesity ([5],[49]). The long-term childhood implications include obesity, type 2 diabetes mellitus , respiratory tract infections, chronic lung disease, bronchial asthma, and chronic obstructive pulmonary
type 2 diabetes mellitus 12216 outcomesPD, PPstillbirthobesityDystociafetal and neonatal deathhypertensionCesarean sectionmacrosomia type 2 diabetes mellitus Gestational diabetes mellitusfetal growth restrictionrespiratory tract infectionHypertensioncongenital
type 2 diabetes mellitus 16767 and coronary artery disease ([66]). Decreased adiponectin level is responsible for the development of type 2 diabetes mellitus . The adiponectin level decreases progressively during normal pregnancies, probably in response to reduced
type 2 diabetes mellitus 18433 Kisspeptin as a neuropeptide is also produced by adipose tissue ([73]). Mice models of obesity and type 2 diabetes mellitus revealed increased hepatic kisspeptin expression and kisspeptin plasma levels. Human liver samples from

You must be authorized to submit a review.