Antiobesity Effects of Anthocyanins in Preclinical and Clinical Studies.

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Insulin 5 endocrinologydiseasesdrugs
hyperglycemia 2 endocrinologydiseases
hyperlipidemia 1 endocrinologydiseases
lipid metabolism disorder 1 endocrinologydiseases
metabolic syndrome 7 endocrinologydiseases
obesity 36 endocrinologydiseases

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Select Drug Character Offset Drug Term Instance
Insulin 31579 abdominal adiposity and dyslipidemiaChange in lipids and lipoproteins60 (19–72/M-F)NCT01005420 (completed) Insulin sensitivity (45 g of blueberry powder)To evaluate the effect of blueberry powder on insulin sensitivity
Insulin 31747 effect of blueberry powder on insulin sensitivity in obese, nondiabetic, and insulin-resistant subjects. Insulin sensitivity37 (>20/M-F)NCT02689765 (completed)Insulin resistance; glucose and lipid metabolism disorders;
Insulin 31801 obese, nondiabetic, and insulin-resistant subjects.Insulin sensitivity37 (>20/M-F)NCT02689765 (completed) Insulin resistance; glucose and lipid metabolism disorders; type 2 diabetes (80 g of a mixture of fresh blueberries
Insulin 32534 function measured by peripheral arterial tonometry25 (14–18/M)NCT02035592 (active, but not recruiting) Insulin resistance; metabolic syndrome X (13–26 g of freeze-dried blueberry powder per day)To determine
Insulin 32863 factors, and lung and cognitive function in overweight and obese participants with metabolic syndrome Insulin resistance144 (50–74/M-F)NCT02291250 (recruiting)Type 2 diabetes (200 g of blackcurrants, which
Select Disease Character Offset Disease Term Instance
hyperglycemia 12394 research groups carried out studies to identify the link between anthocyanin compounds and hyperlipidemia, hyperglycemia , hypertension, inflammation, and immunity that cause diabetes, cardiovascular diseases, and other inflammation-related
hyperglycemia 18776 et al. [[57]] found that anthocyanin-rich Aronia fruits could suppress visceral fat accumulation and hyperglycemia through the inhibition of pancreatic lipase activity and thus lead to a reduction of intestinal lipid
hyperlipidemia 12378 years, many research groups carried out studies to identify the link between anthocyanin compounds and hyperlipidemia , hyperglycemia, hypertension, inflammation, and immunity that cause diabetes, cardiovascular diseases,
lipid metabolism disorder 31833 insulin-resistant subjects.Insulin sensitivity37 (>20/M-F)NCT02689765 (completed)Insulin resistance; glucose and lipid metabolism disorder s; type 2 diabetes (80 g of a mixture of fresh blueberries and blackcurrants)To characterize the potential
metabolic syndrome 20746 are needed to assess the preventive effects of anthocyanin-containing foods in obesity, diabetes, and metabolic syndrome due to the difficulty to establish the optimal dose and to identify the ideal food matrix for the best
metabolic syndrome 21886 risk of cardiovascular disease and insulin resistance. In one case, 48 subjects, largely women, with metabolic syndrome and an average BMI of 37.8 ± 2.3 kg/m2, received for 8 weeks a blueberry beverage containing
metabolic syndrome 22418 than in the control group, suggesting that blueberry beverage could contribute to ameliorate improve metabolic syndrome and related cardiovascular risk factors [[63]]. In the second study, 32 obese men and women with a BMI
metabolic syndrome 24510 the studies where other metabolic dysfunctions associated with obesity have been considered, such as metabolic syndrome , the supplementation with anthocyanin-enriched foods, for example, berry, in general, did not change
metabolic syndrome 24987 effects of anthocyanin supplementation in overweight and obese subjects and in individuals affected by metabolic syndrome have also been observed when other clinical parameters have been measured, such as diastolic and systolic
metabolic syndrome 32554 peripheral arterial tonometry25 (14–18/M)NCT02035592 (active, but not recruiting)Insulin resistance; metabolic syndrome X (13–26 g of freeze-dried blueberry powder per day)To determine the dose-dependent impact of blueberry
metabolic syndrome 32845 cardiovascular disease risk factors, and lung and cognitive function in overweight and obese participants with metabolic syndrome Insulin resistance144 (50–74/M-F)NCT02291250 (recruiting)Type 2 diabetes (200 g of blackcurrants,
obesity 52 Title: Oxidative Medicine and Cellular LongevityAnti obesity Effects of Anthocyanins in Preclinical and Clinical StudiesElena AzziniJasminka GiacomettiGian Luigi
obesity 645 7/2017AbstractThe natural phytochemicals present in foods, including anthocyanins, might play a role in attenuating obesity by producing a decrease in weight and adipose tissue. This review focused on current knowledge about
obesity 776 in weight and adipose tissue. This review focused on current knowledge about anthocyanins' role in obesity and its related comorbidities reported in animal models and humans. We summarized their target identification
obesity 1143 highlighted the following key points: a healthy relationship between anthocyanin supplementation and anti obesity effects suffers of the same pros and cons evidenced when the beneficial responses to other phytochemical
obesity 1978 turn, allow the design of more efficient and prevention-targeted clinical studies.1. IntroductionThe obesity and its related comorbidities represent an emerging global health issue. In 2014, WHO estimated overall
obesity 2221 adult population (11% of men and 15% of women) were obese. Additionally, the worldwide prevalence of obesity is more than doubled between 1980 and 2014 [[1]]. Obesity is an abnormal excess accumulation of fat
obesity 2614 processes to produce heat and energy expenditure for physical activity level. The key element to counteract obesity is moderate weight loss (5–10%) over time through an integrated treatment [[2]]. This is expressed
obesity 3527 anti-inflammatory actions [[3]]. It has been reported that the anthocyanins might play a role in attenuating obesity by producing a decrease in weight and adipose tissue [[4]]. Controversial results were obtained in animals
obesity 3663 weight and adipose tissue [[4]]. Controversial results were obtained in animals and human studies in obesity condition [[5]–[11]] by type of supplementation (fresh and/or commercial product or pure compound),
obesity 4280 whole foods [[12]]. Thus, this review is focused on the current knowledge about anthocyanins' role in obesity and its related comorbidities reported in animal models and humans.2. Anthocyanins2.1. Anthocyanin ChemistryAnthocyanins
obesity 10661 of several metabolites poorly absorbed and rapidly removed from plasma does not impair to ameliorate obesity and related comorbidities [[33], [34]]. Furthermore, Cardona et al. [[35]] reviewed that, like drugs
obesity 12058 antioxidative, and metabolic-stabilizing activity. These mechanisms are associated with stabilization of obesity and diabetes, improvements in blood pressure and lipid profiles, decreased atherosclerotic development,
obesity 13355 prevention could promote interest in drug discovery and the potential of diets in the prevention of obesity and several diseases.Prior et al. [[38]] reported that supplemented diet with a blueberry extract (BBE)
obesity 13969 obese mice [[26], [39]]. A fermented blueberry-blackberry beverage also mitigates the development of obesity and reduces fasting blood glucose in C57BL/6J mice [[40]]. In addition, the consumption of both BBJ
obesity 14564 signaling pathways, which might suggest their cytoprotective and anti-inflammatory role in the pathology of obesity [[39]].Seymour et al. [[42]] described that supplementation with 2% (wt/wt) blueberry powder (BBP) reduced
obesity 15419 [[44]].Bilberries can also reduce inflammation, prevent chronic hypertension, and thus mitigate the development of obesity as reported by Mykkänen et al. [[45]]. Black elderberry (BE) is one of the richest sources of anthocyanins,
obesity 16723 diet-induced obese mice after GF treatment for 12 weeks. In addition, GF administration to HF mice arose obesity -associated IR and hepatic lipid accumulation through the modulation of AMPK activity and lipid metabolism-associated
obesity 17159 anti-inflammatory properties of blueberry (BB), blackberry (BK), and blackcurrant (BC) in a diet-induced obesity (DIO) mouse model were reported by Kim et al. [[54]]. Since BB, BK, and BC vary in the anthocyanin composition,
obesity 17895 compare the antioxidant status of nonobese and obese mice in a model with monosodium glutamate-induced obesity . CBE treatment increased the thiol content in the plasma and the glutathione S-transferase activity
obesity 18649 male C57BL/6J mice. Therefore, this supplementation prevented weight gain and modulated markers of obesity [[56]]. Takahashi et al. [[57]] found that anthocyanin-rich Aronia fruits could suppress visceral fat
obesity 19659 lipopolysaccharides [[58]].Gut microbes are important due to their possible involvement in the development of obesity process and chronic inflammation as well as IR [[59]]. In addition to being designed to reduce adiposity
obesity 20446 the encouraging results obtained by preclinical studies in animal models, the role of anthocyanins in obesity deriving from clinical trials remains controversial. Few interesting reviews have been published in
obesity 20723 interventional studies are needed to assess the preventive effects of anthocyanin-containing foods in obesity , diabetes, and metabolic syndrome due to the difficulty to establish the optimal dose and to identify
obesity 20965 best anthocyanin supplementation [[27], [61]]. Observational studies are more prone to suggest an anti obesity role of this class of polyphenols. In a recent work which analyzed food frequency questionnaires from
obesity 23733 anthocyanins in 30 overweight healthy human volunteers for 12 weeks also resulted in a significant anti obesity effect measured as reduction in body mass index (BMI; 1.11 ± 0.09 kg/m2) compared to the placebo
obesity 24472 inflammation and lipid metabolism [[67]].In the studies where other metabolic dysfunctions associated with obesity have been considered, such as metabolic syndrome, the supplementation with anthocyanin-enriched foods,
obesity 25916 the challenges of this field in the next years.The uncertainty of the clinical studies proving anti obesity effects of anthocyanins is confirmed by data summarized in Table 1. Here, we interrogated the http://ClinicalTrials.gov
obesity 26137 http://ClinicalTrials.gov database, a service of the U.S. National Institutes of Health, for “anthocyanins” and “ obesity ” and retrieved a total of 16 studies (last update March 28, 2017). Those more closely related to the
obesity 26765 which may generate confounding results due to the age-related differences in the physiopathology of obesity and related diseases; and (iii) wide differences in the type, composition, origin, doses, and duration
obesity 27643 conclude that the potential functional relationship existing between anthocyanin supplementation and anti obesity effects suffers of the same pros and cons evidenced when the beneficial responses to other phytochemical
obesity 28945 shorter time of administration. As an example, it is risky to hypothesize that anthocyanins can prevent obesity based on studies on already obese mice that received pharmacological doses of these phytochemicals.
obesity 30551 protein-1.Table 1Clinical studies retrieved from the http://ClinicalTrials.gov database on anthocyanins and obesity .Trial number statusConditions and dosageObjectivesPrimary outcomeNumber of subjects (age/sex)NCT02613715
obesity 30690 and dosageObjectivesPrimary outcomeNumber of subjects (age/sex)NCT02613715 (completed)Overweight and obesity (250 ml of blackberry juice)To evaluate the bioavailability of blackberry juice anthocyanins in normal
obesity 31296 in the adipose tissueOral glucose tolerance test60 (40–70/M)NCT01883401 (completed)Dyslipidemia; obesity (25–50 g freeze-dried strawberries/day)To determine the effects of low and high doses of freeze-dried
obesity 32190 type 2 prediabetesChange in fasting glucose and HbA1C160 (40–75/M-F)NCT01705093 (unknown)Childhood obesity ; cardiovascular disease (50 g of flavonoid-rich freeze-dried strawberry powder)To verify if strawberry
obesity 33763 aggregates84 (30–50/M-F)NCT01564498 (recruiting)Hypertension; hypercholesterolemia; type II diabetes; obesity ; inflammation (300–500 g of cooked white/purple potatoes per day, or 300–500 g of raw orange/purple

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