Marine Peptides as Potential Agents for the Management of Type 2 Diabetes Mellitus-A Prospect

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Term Occurence Count Dictionary
type 2 diabetes mellitus 2 endocrinologydiseases
Insulin 5 endocrinologydiseasesdrugs
diabetes mellitus 3 endocrinologydiseases
hyperglycemia 8 endocrinologydiseases
obesity 1 endocrinologydiseases

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Select Drug Character Offset Drug Term Instance
Insulin 3581 discussed for the future novel marine peptides investigation.2. Regulation of Bioactive Peptides on the Insulin -Regulated Glucose Metabolism2.1. Protecting Pancreatic β-Cells of Bioactive PeptidesAdequate insulin
Insulin 10147 obesity-associated insulin resistance and anti-inflammation [[42]].2.2. Enhancement of Glucose-Stimulated Insulin SecretionIt has been revealed that T2DM develops when the insulin secretory capacity is unable to compensate
Insulin 18110 a potential compound on regulation of T2DM via inhibitory lipid accumulation.2.4. Regulation of the Insulin -Signaling PathwaysCorrection insulin resistance is an important therapeutic strategy for T2DM. Insulin
Insulin 18213 Insulin-Signaling PathwaysCorrection insulin resistance is an important therapeutic strategy for T2DM. Insulin resistance is a physiological condition, in which cells fail to respond to the normal actions of the
Insulin 18405 normal actions of the hormone insulin, and reduction or impairment of insulin-stimulated glucose uptake. Insulin receptor substrate-1/phosphoinositide-3-kinase/protein kinase B (IRS-1/PI3K/Akt) signaling pathways
Select Disease Character Offset Disease Term Instance
diabetes mellitus 729 health in the last future worldwide. There is limited evidence on the potential management of type 2 diabetes mellitus using bioactive peptides from marine organisms, besides from milk and beans. We summarized here recent
diabetes mellitus 1684 known as a seriously chronic metabolism disorder. According to the forecast, the prevalence of type 2 diabetes mellitus (T2DM) will increase from 350 million today to 592 million by 2035 [[1]]. The nutrient overload in prolonged
diabetes mellitus 12622 modifications, control and prevention of hyperglycemia are primary approaches in the management of diabetes mellitus , which is involved in several physiological processes, such as increasing utilization of the glucose
hyperglycemia 2650 medicine, due to its supplements, and exhibited benefits for some health disorders, such as dyslipidemia, hyperglycemia , and hypertension as well as weight loss in several studies [[7],[8]]. These results indicated that
hyperglycemia 4304 adapt to maintaining glucose homeostasis at the high glucose challenges over prolonged periods [[4]], hyperglycemia was developed, which was verified to generate over-production of free radical species including reactive
hyperglycemia 5944 (SOD) in islets only around 30% of those in the liver [[22],[23]]. Obviously, as induced by chronic hyperglycemia and exposure to proinflammatory cytokines, the poor antioxidant defense capability of pancreatic β
hyperglycemia 7090 administered goby fish protein hydrolysates, not undigested goby fish protein, can significantly attenuate hyperglycemia and restored the antioxidant status under high-fat-high-fructose diet-induced oxidative stress in rats
hyperglycemia 12564 (World Health Organization, 1999). Besides diet and lifestyle modifications, control and prevention of hyperglycemia are primary approaches in the management of diabetes mellitus, which is involved in several physiological
hyperglycemia 14372 influenced by chlorella consumption [[73]] Aglycin, a peptide from soy, exhibited effectively in preventing hyperglycemia in a diabetic animal model with impaired glucose tolerance and insulin resistance, which were induced
hyperglycemia 22406 peptides, the efficacy of Chlorella vulgaris (C.Vulgaris) in prevention and treatment of dyslipidemia, hyperglycemia , hypertension as well as weight loss was found in literature [[97],[98],[99]]. C. vulgaris, a single-celled
hyperglycemia 23471 Inhibition of Bioactive Peptides to α-Amylase and α-Glucosidase ActivitiesOther approaches to decrease hyperglycemia are to control or delay glucose absorption by inhibition of α-glucosidase or α-amylase in the gastrointestinal
obesity 10041 adipokines in pancreatic β-cells now being believed to play a negative role in the development of obesity -associated insulin resistance and anti-inflammation [[42]].2.2. Enhancement of Glucose-Stimulated Insulin
type 2 diabetes mellitus 722 human health in the last future worldwide. There is limited evidence on the potential management of type 2 diabetes mellitus using bioactive peptides from marine organisms, besides from milk and beans. We summarized here recent
type 2 diabetes mellitus 1677 mellitus is known as a seriously chronic metabolism disorder. According to the forecast, the prevalence of type 2 diabetes mellitus (T2DM) will increase from 350 million today to 592 million by 2035 [[1]]. The nutrient overload in prolonged

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