Role of Plasminogen Activator Inhibitor Type 1 in Pathologies of Female Reproductive Diseases.

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Annotation Summary

Term Occurence Count Dictionary
diabetes mellitus 4 endocrinologydiseases
hyperandrogenism 1 endocrinologydiseases
metformin 2 endocrinologydiseasesdrugs
pioglitazone 1 endocrinologydiseasesdrugs
polycystic ovary syndrome 2 endocrinologydiseases
testosterone 1 endocrinologydiseasesdrugs
type 2 diabetes mellitus 2 endocrinologydiseases
Insulin 2 endocrinologydiseasesdrugs

Graph of close proximity drug and disease terms (within 200 characters).

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Select Drug Character Offset Drug Term Instance
Insulin 23322 than seven-fold increased risk of developing postpartum diabetes compared to women without GDM [[97]]. Insulin resistance and chronic subclinical inflammation are the two main pathways leading to GDM and possibly
Insulin 23453 subclinical inflammation are the two main pathways leading to GDM and possibly previous GDM [[98]]. Insulin resistance syndrome is associated with increased levels of leptin, TNF-α, tPA, PAI-1 and testosterone
metformin 28242 and insulin sensitivity indices [[121]]. PAI-1 levels decline after treatment with sibutramine and metformin in normal weight and overweight women with PCOS [[118],[122]].Oligo-ovulation (defined as delayed menses
metformin 30440 as the oral intake of thiazolidinedines (troglitazone or pioglitazone) [[100]], statins [[100]] and metformin [[118]]. Altered PAI-1 levels have further been found in other pathologies. Studies on cardiovascular
pioglitazone 30397 exercise and pharmacological interventions, such as the oral intake of thiazolidinedines (troglitazone or pioglitazone ) [[100]], statins [[100]] and metformin [[118]]. Altered PAI-1 levels have further been found in other
testosterone 23551 [[98]]. Insulin resistance syndrome is associated with increased levels of leptin, TNF-α, tPA, PAI-1 and testosterone [[99]].PAI-1 is partly secreted by adipose tissue, and can lead to an impairment of the fibrinolytic
Select Disease Character Offset Disease Term Instance
diabetes mellitus 1664 recurrent pregnancy losses (RPL), preeclampsia, intrauterine growth restriction (IUGR), gestational diabetes mellitus (GDM) in the previous pregnancy, endometriosis and polycystic ovary syndrome (PCOS). In general, an
diabetes mellitus 22875 risk of IUGR in the case-control analysis [[94],[95]].3.5. Gestational Diabetes MellitusGestational diabetes mellitus (GDM) is characterized by impaired glucose tolerance during pregnancy, with the prevalence of 0.6–20%
diabetes mellitus 27745 oligo-ovulation and polycystic ovarian morphology [[117]]. PCOS is associated with infertility, RPL, type 2 diabetes mellitus and cardiovascular diseases [[117]]. Many studies in women with PCOS have reported that PAI-1 levels
diabetes mellitus 29216 with PCOS [[126]]. Elevated plasma PAI-1 levels are associated with an increased risk for both type 2 diabetes mellitus and cardiovascular diseases (i.e., coronary disease/ischemic stroke) [[127],[128],[129]].PAI-1 4G/5G
hyperandrogenism 27594 endocrinopathy of women in the reproductive age, with a prevalence of up to 10% and symptoms include hyperandrogenism and/or hyperandrogenemia, oligo-ovulation and polycystic ovarian morphology [[117]]. PCOS is associated
polycystic ovary syndrome 1733 restriction (IUGR), gestational diabetes mellitus (GDM) in the previous pregnancy, endometriosis and polycystic ovary syndrome (PCOS). In general, an increased expression of PAI-1 in the blood is associated with an increased risk
polycystic ovary syndrome 4159 including recurrent pregnancy losses, preeclampsia, intrauterine growth restriction, endometriosis and polycystic ovary syndrome .2. Fibrinolytic System and PAI-1 (Plasminogen Activator Inhibitor Type 1)The prime fibrinolytic protease
type 2 diabetes mellitus 27738 oligo-ovulation and polycystic ovarian morphology [[117]]. PCOS is associated with infertility, RPL, type 2 diabetes mellitus and cardiovascular diseases [[117]]. Many studies in women with PCOS have reported that PAI-1 levels
type 2 diabetes mellitus 29209 women with PCOS [[126]]. Elevated plasma PAI-1 levels are associated with an increased risk for both type 2 diabetes mellitus and cardiovascular diseases (i.e., coronary disease/ischemic stroke) [[127],[128],[129]].PAI-1 4G/5G

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