Acupuncture for polycystic ovarian syndrome: A systematic review and meta-analysis.

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obesity 1 endocrinologydiseases
testosterone 16 endocrinologydiseasesdrugs
hyperandrogenism 1 endocrinologydiseases
metformin 13 endocrinologydiseasesdrugs

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Select Drug Character Offset Drug Term Instance
metformin 11889 an adjunct to CC,[[21],[22],[28],[33],[35],[36],[38]] Chinese herbal medicine (CHM),[[26],[27],[40]] metformin ,[[20],[32]] Diane-35, or combinations of these.[[15],[25],[34],[39],[41]] Nineteen trials used manual
metformin 16184 improvement in monthly menstruation rates in women who received acupuncture compared to those who received metformin (MD 0.14, 95% CI 0.05 to 0.23, P = .003).[[42]] The pooled results from 6 studies[[22],[24],[29]–[31],[42]]
metformin 16647 according to the control type, and the pooled results from 2 studies[[29],[42]] comparing acupuncture with metformin showed a significant difference in testosterone levels in the acupuncture group compared to the medication
metformin 18384 2). When we conducted a subgroup analysis according to the control medication type, acupuncture plus metformin [[20],[32]] showed a significant difference in LH levels compared with sham acupuncture with metformin
metformin 18486 metformin[[20],[32]] showed a significant difference in LH levels compared with sham acupuncture with metformin (MD −0.99, 95% CI −1.35 to −0.63, P < .00001, I2 = 0%, Fig. S2). The pooled results in
metformin 18880 0.00, P = .06, I2 = 94%, Table 2). A subgroup analysis revealed that true acupuncture with metformin [[20],[32]] also showed a marginally significant difference in testosterone levels compared with sham
metformin 19008 showed a marginally significant difference in testosterone levels compared with sham acupuncture with metformin (MD −0.05, 95% CI −0.10 to 0.00, P = .04, I2 = 54%, Fig. S2). There was no evidence of a
metformin 19294 S2).Adverse events: One study[[20]] reported that 22 patients (43.14%) in the sham acupuncture with metformin group had nausea or vomiting, mild diarrhea, and slight dizziness or weakness, while 18 patients (33.96%)
metformin 19439 diarrhea, and slight dizziness or weakness, while 18 patients (33.96%) in the true acupuncture with metformin group experienced these events. Three studies[[32],[35],[37]] did not report adverse events.Acupuncture
metformin 20310 control group revealed that acupuncture added to combined medication (CHM plus CC),[[34]] (CHM plus metformin and Diane-35),[[25]] (metformin with Diane-35)[[39]] only showed a significant difference in LH levels
metformin 20342 acupuncture added to combined medication (CHM plus CC),[[34]] (CHM plus metformin and Diane-35),[[25]] ( metformin with Diane-35)[[39]] only showed a significant difference in LH levels when compared with combined medication
metformin 22845 improve ovulation and menstruation rates compared to not receiving acupuncture. When compared with metformin , acupuncture improves menstruation rates but the level of evidence is also low. We found statistically
metformin 27618 trials reported that when acupuncture was added, it reduced adverse events associated with CC[[22]] or metformin .[[20]] Future clinical trials should not neglect to report adverse events associated with acupuncture
testosterone 1771 an adjunct to medication in luteinizing hormone (LH), LH/follicular stimulating hormone (FSH) ratio, testosterone , fasting insulin, and pregnancy rates, but the level of evidence was low/very low.Conclusion:There is
testosterone 3778 PCOS.[[5]] Acupuncture has also been reported to potentially improve insulin sensitivity and to decrease testosterone in patients with PCOS.[[10],[11]]Recently, several systematic reviews on acupuncture for PCOS were published.[[12]–[14]]
testosterone 12919 LH,[[10],[20],[21],[24]–[27],[29]–[35],[37],[39],[40],[42]–[44]] LH/FSH ratio,[[10],[20]–[22],[24]–[27],[29],[31],[32],[34],[37],[39],[41]–[44]] testosterone ,[[10],[20]–[22],[24]–[35],[37],[39]–[43]] fasting insulin levels,[[10],[20],[25],[26],[29],[33],[34],[37],[41],[42]]
testosterone 15354 studies)3.3.2Outcomes: There was evidence of improvement in ovulation rates, monthly menstruation rates, and testosterone levels in the acupuncture group compared to no treatment (Table 2).[[10],[43]] There were no studies
testosterone 16344 P = .003).[[42]] The pooled results from 6 studies[[22],[24],[29]–[31],[42]] showed no significant difference in testosterone levels between the acupuncture and medication groups (MD −0.04, 95% CI −0.11 to 0.03, P = .30,
testosterone 16692 results from 2 studies[[29],[42]] comparing acupuncture with metformin showed a significant difference in testosterone levels in the acupuncture group compared to the medication group (MD −0.13, 95% CI −0.21 to −0.05,
testosterone 18597 (MD −0.99, 95% CI −1.35 to −0.63, P < .00001, I2 = 0%, Fig. S2). The pooled results in testosterone levels[[20],[32],[35]] showed a marginally significant difference between true acupuncture with medicine
testosterone 18952 that true acupuncture with metformin[[20],[32]] also showed a marginally significant difference in testosterone levels compared with sham acupuncture with metformin (MD −0.05, 95% CI −0.10 to 0.00, P = .04,
testosterone 19782 monthly menstruation rates (per woman). There was evidence of an improvement in LH levels, LH/FSH ratios, testosterone levels, fasting insulin levels,[[25],[26],[33],[34],[41]] and pregnancy rates[[21],[28],[33],[34],[36],[41]]
testosterone 20680 acupuncture produced a significant improvement in LH/FSH ratios[[21],[22],[25]–[27],[34],[39],[41]] and testosterone levels[[21],[22],[25]–[28],[33],[34],[39]–[41]] with considerable heterogeneity (Fig. S3). We conducted
testosterone 22013 domain was downgraded for unexplained heterogeneity in the outcomes: LH levels, LH/FSH ratios, and testosterone levels in the acupuncture versus sham acupuncture group; LH levels in the acupuncture versus no treatment
testosterone 22150 acupuncture versus sham acupuncture group; LH levels in the acupuncture versus no treatment group; LH levels, testosterone levels in the acupuncture versus medication group, LH levels, LH/FSH ratios, testosterone levels in
testosterone 22240 LH levels, testosterone levels in the acupuncture versus medication group, LH levels, LH/FSH ratios, testosterone levels in the acupuncture plus medication versus sham acupuncture plus medication group; and LH levels,
testosterone 22372 acupuncture plus medication versus sham acupuncture plus medication group; and LH levels, LH/FSH ratios, testosterone levels in the acupuncture plus medication versus medication alone group (Table 2).Discussion4Summary
testosterone 23086 acupuncture treatment for up to 4 months as an adjunct to medication, seen in LH levels, LH/FSH ratios, testosterone levels, fasting insulin, and pregnancy rates, but the level of evidence is very low or low, mainly due
testosterone 25860 acupuncture adjuvant to other active medications could affect hormonal levels such as LH, LH/FSH ratio, testosterone , and fasting insulin. Neuroendocrinological mechanisms of acupuncture have been extensively studied
Select Disease Character Offset Disease Term Instance
hyperandrogenism 2183 needed.Introduction1Polycystic ovarian syndrome (PCOS) is diagnosed on the basis of oligo-ovulation or anovulation, hyperandrogenism , and the presence of polycystic ovaries.[[1]] The prevalence of PCOS is as high as 15% when the Rotterdam
obesity 11399 together.[[20]–[22],[31],[32],[34],[36],[38]] Although 7 studies were conducted only in patients with obesity -type PCOS (body mass index (BMI) ≥25 kg/m2),[[20],[26],[32],[34],[37],[41],[42]] 7 did not report

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