How Can Genetic Studies Help Us to Understand Links Between Birth Weight and Type 2 Diabetes?

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Term Occurence Count Dictionary
Insulin 2 endocrinologydiseasesdrugs
hyperglycemia 5 endocrinologydiseases

Graph of close proximity drug and disease terms (within 200 characters).

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Select Drug Character Offset Drug Term Instance
Insulin 991 associated both with a higher risk of type 2 diabetes and a lower birth weight. This supports the Fetal Insulin Hypothesis and reflects a general pattern for type 2 diabetes susceptibility alleles: genome-wide, there
Insulin 5561 of low birth weight with either impaired insulin secretion or greater insulin resistance, the Fetal Insulin Hypothesis was proposed [[]]; alleles that predispose to reduced insulin secretion or raised insulin
Select Disease Character Offset Disease Term Instance
hyperglycemia 5385 reduce glucose sensing by the pancreas, cause both a reduction in insulin-mediated fetal growth and hyperglycemia after birth. Based on this and other rare, monogenic examples of low birth weight with either impaired
hyperglycemia 9996 maternal risk allele and higher birth weight. The latter is consistent with a primary effect on maternal hyperglycemia GWAS Enable Genome-Wide Assessments of the Genetic Link Between Type 2 Diabetes and Birth WeightGenetic
hyperglycemia 14851 type 2 diabetes than in those whose mothers developed diabetes after pregnancy. Exposure to maternal hyperglycemia in utero results in increased fetal growth as a result of higher fetal insulin secretion, while shared
hyperglycemia 15175 the difference between the offspring of prediabetic vs. diabetic mothers suggests that intrauterine- hyperglycemia exposure additionally contributes to a higher risk of type 2 diabetes in later life, likely through
hyperglycemia 17924 association between higher birth weight and type 2 diabetes that operate independently of maternal hyperglycemia .The Relative Effects on Birth Weight of Genetic Variants Associated with Type 2 Diabetes Give Clues

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