Diabetes and Wound Angiogenesis.

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Annotation Summary

Term Occurence Count Dictionary
diabetic foot 3 endocrinologydiseases
diabetic retinopathy 3 endocrinologydiseases
hyperglycemia 2 endocrinologydiseases
metformin 1 endocrinologydiseasesdrugs
obesity 2 endocrinologydiseases

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Select Drug Character Offset Drug Term Instance
metformin 13721 studied being cancer. In a study by Chen et al., a popular drug used for the treatment of diabetes, metformin , was shown to decrease prostate cancer cell proliferation, migration and tumor growth through a mechanism
Select Disease Character Offset Disease Term Instance
diabetic foot 2566 amputation approaching 50–59% five-year post-amputation [[3],[4],[5],[6]]. Studies of the pathology of diabetic foot ulceration have focused on microbial invasion, epithelial breakdown, and impaired immune function as
diabetic foot 23692 expression levels. In one such study, PEDF was shown to occur at higher circulating levels in patients with diabetic foot ulcers compared to both non-diabetic and diabetic patients without DFU [[86]]. While this study might
diabetic foot 30778 an over 20-year track record in the clinic, is still not a complete answer for treating non-healing diabetic foot wounds. Another therapy that has been attempted is the use of growth factors such as VEGF and PDGF.
diabetic retinopathy 9111 [[35]]. Dysfunctional angiogenesis has been implicated in the pathophysiology of atherosclerosis and diabetic retinopathy as well as many other comorbidities that affect diabetic patients [[36]].4. Angiogenesis in Wound HealingWound
diabetic retinopathy 18954 diabetes-related changes in the angiogenic response can be tissue and/or organ dependent. For example, in diabetic retinopathy (DR) excessive angiogenesis occurs, leading to a pathology that is characterized by microaneurysms,
diabetic retinopathy 19195 vascular edema [[75]]. Along with increased capillary growth, a hallmark vascular modification seen in diabetic retinopathy is the loss of pericyte coverage in the retinal capillary network. This loss of pericytes is conducive
hyperglycemia 1376 healing outcomes.1. IntroductionDiabetes mellitus type II (DM2) is a metabolic disorder defined by hyperglycemia due to insulin resistance. DM2 has become a major global health epidemic with a particularly large incidence
hyperglycemia 17785 healthy vascular system. Perturbations in vascular integrity are also a feature of diabetes. Diabetic hyperglycemia , particularly in DM2, has been implicated in the progression of vascular disease in a multitude of both
obesity 21967 been widely used for wound healing studies is the db/db mouse. The db/db mouse is a genetic model of obesity , diabetes, and dyslipidemia that results from a mutation in the leptin receptor gene, and db/db mice
obesity 28328 in our laboratory have found that wounds of mice subjected to a high fat diet (HFD), a diet induced obesity model (DIO) that closely approximates DM2, present with more tortuous and aberrant architecture [[104]].

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