Hepatitis C virus infection and risk of osteoporosis: A meta-analysis.

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cholecalciferol 1 endocrinologydiseasesdrugs
osteoporosis 21 endocrinologydiseases

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cholecalciferol 10650 proliferation.[[13][22]] Furthermore, patients with chronic liver disease tend to have impaired hepatic hydroxylation of cholecalciferol , the first step in the synthesis of the active form of vitamin D, which could result in vitamin D deficiency
Select Disease Character Offset Disease Term Instance
osteoporosis 141 : Official Journal of the Saudi Gastroenterology AssociationHepatitis C virus infection and risk of osteoporosis : A meta-analysisKarn WijarnpreechaCharat ThongprayoonPanadeekarn PanjawatananParkpoom PhatharacharukulPatompong
osteoporosis 972 epidemiologic studies have suggested that patients with HCV infection might be at an increased risk of osteoporosis . However, the data on this relationship remains inconclusive. This meta-analysis was conducted with
osteoporosis 1343 2016. Studies that reported relative risks, odd ratios (OR), or hazard ratios comparing the risk of osteoporosis among HCV-infected patients versus those without HCV infection were included. Pooled OR and 95% confidence
osteoporosis 1659 method.Results:Four studies met our eligibility criteria and were included in the analysis. We found a higher risk of osteoporosis among patients with chronic HCV with OR of 1.65 (95% CI: 0.98–2.77). Sensitivity analysis including
osteoporosis 1957 statistically significant (OR: 2.47; 95% CI: 1.03–5.93).Conclusions:Our study demonstrated a higher risk of osteoporosis among HCV-infected patients. Further studies are required to clarify how this risk should be addressed
osteoporosis 2280 by reduced bone mass and increased risk of fragility fracture.[[1]] Well-established risk factors of osteoporosis include immobility, aging, menopause, diabetes, chronic use of glucocorticoid, vitamin D deficiency,
osteoporosis 3048 monoinfection or healthy controls.[[6][7]] However, data on the association of HCV monoinfection and osteoporosis remains inconclusive.[[8][9][10][11][12][13]] This systematic review and meta-analysis was conducted
osteoporosis 3233 meta-analysis was conducted with the aim to summarize all available evidence to assess the risk of osteoporosis among HCV-infected patients.MATERIALS AND METHODSSearch strategyTwo investigators (K.W. and P.U.) independently
osteoporosis 3538 inception to June 2016 using the search strategy that included the terms for “hepatitis C virus” and “ osteoporosis ,” as described in online supplementary data 1. No language limitation was applied. A manual search
osteoporosis 3910 case-control, cross-sectional, or cohort studies published as original articles to evaluate the risk of osteoporosis among HCV-infected patients compared with individuals without HCV infection, (2) odds ratios (OR), relative
osteoporosis 5257 demographic data, method used to identify and verify HCV infection, as well as the event of interest ( osteoporosis ), adjusted effect estimates with 95% CI, and covariates that were adjusted in the multivariate analysis.To
osteoporosis 8006 of the studies included in this meta-analysis of the association between HCV infection and risk of osteoporosis In the overall analysis, we found a higher risk of osteoporosis among patients with chronic HCV compared
osteoporosis 8069 association between HCV infection and risk of osteoporosisIn the overall analysis, we found a higher risk of osteoporosis among patients with chronic HCV compared with individuals without HCV infection with an OR of 1.65 (95%
osteoporosis 8948 4Funnel plotDISCUSSIONThis study is the first systematic review and meta-analysis to assess the risk of osteoporosis among HCV-infected patients. We found that the risk of osteoporosis was higher among HCV-infected patients
osteoporosis 9016 meta-analysis to assess the risk of osteoporosis among HCV-infected patients. We found that the risk of osteoporosis was higher among HCV-infected patients compared with those without HCV infection, with approximately
osteoporosis 9338 yielded a higher OR and reached statistical significance.The exact mechanisms behind the association of osteoporosis and HCV infection are not known. It is possible that either chronic liver disease associated with HCV
osteoporosis 9572 infection itself is responsible for the reduced BMD.Abnormal bone metabolism resulting in low BMD and osteoporosis is a known complication of chronic liver disease. It has been demonstrated that patients with cirrhosis
osteoporosis 10428 controls.[[9][20]] Decreased levels of these two growth factors may contribute to the development of osteoporosis because both IGF-1 and IGFBP-3 play an essential role in osteoblast differentiation and proliferation.[[13][22]]
osteoporosis 10803 the active form of vitamin D, which could result in vitamin D deficiency and, ultimately, osteopenia/ osteoporosis .[[23][24]]The implication of HCV infection itself on bone metabolism is less known. It has been reported
osteoporosis 12130 included in this meta-analysis did not adjust their effect estimates for several known risk factors for osteoporosis such as diabetes, use of glucocorticoids, and immobility. Thus, it is possible that the observed association
osteoporosis 12735 including Caucasians and Africans.In summary, this meta-analysis demonstrated an increased risk of osteoporosis among HCV-infected patients. Further studies are required to clarify how this risk should be addressed

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