Candidate gene studies of diabetic retinopathy in human

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Term Occurence Count Dictionary
obesity 1 endocrinologydiseases
Insulin 3 endocrinologydiseasesdrugs
diabetes mellitus 1 endocrinologydiseases
diabetic angiopathy 1 endocrinologydiseases
diabetic retinopathy 12 endocrinologydiseases
hyperhomocysteinemia 1 endocrinologydiseases

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Select Drug Character Offset Drug Term Instance
Insulin 13443 T − 553 Ac. T−834A42CaucasianAT genotype could be risk factor for PDR during T2DM[[50]]IGF-1 Insulin -like growth factor 1Stimulation of cell growth and proliferation, inhibition of apoptosis(CA)n42Southern
Insulin 21720 K198N)62ChineseReduced risk in Chinese[[77], [105]]ENPP1Ectonucleotide pyrophosphatase/phosphodiesterase 1 Insulin resistance, interaction with integrinsrs140918161African AmericanSignificant associations with severe
Insulin 23280 effects in immunoregulation and inflammationn. A-1082G12IndianG allele is risk factor for PDR[[113]]INSR Insulin receptorActivation of the insulin signaling pathwayrs10500204191African AmericanAssociated with progression
Select Disease Character Offset Disease Term Instance
diabetes mellitus 1724 microvascular complications such as retinopathy, nephropathy and neuropathy [[1]].The number of patients with diabetes mellitus is rapidly increasing every year. Global mortality resulting from diabetes in adults was estimated to
diabetic angiopathy 37777 and in vivo studies that suggests a pathogenic role of the complement system in the development of diabetic angiopathy . In these studies, increased expression of several complement factors, namely, complement factor H (CFH),
diabetic retinopathy 58 Title: Molecular Biology ReportsCandidate gene studies of diabetic retinopathy in humanPetra PriščákováGabriel MinárikVanda RepiskáPublication date (epub): 10/2016Publication
diabetic retinopathy 493 productive age. The purpose of this literature review is to highlight recent achievements in the genetics of diabetic retinopathy with particular focus on candidate gene studies. We summarized most of the available published data
diabetic retinopathy 640 candidate gene studies. We summarized most of the available published data about candidate genes for diabetic retinopathy with the goal to identify main genetic aspects. We conclude that genetic studies reported contradictory
diabetic retinopathy 2834 [[1]]. DR is classified into two categories based on severity, namely less-severe nonproliferative diabetic retinopathy (NPDR) and severe proliferative diabetic retinopathy (PDR). The key changes of the retina in NPDR, as
diabetic retinopathy 2887 severity, namely less-severe nonproliferative diabetic retinopathy (NPDR) and severe proliferative diabetic retinopathy (PDR). The key changes of the retina in NPDR, as a result of hypoxia and venous bleading, are microaneurysms,
diabetic retinopathy 3267 ischemia is the main characteristic of PDR [[3]].Fig. 1Symptoms and pathological processies typical for diabetic retinopathy leading to vision lost. EBM endothelial basal membrane, BRB blood retinal barrier, EC endothelial cellThe
diabetic retinopathy 5310 2Putative roles of genes identified by candidate genes studies in pathophysiological processies during diabetic retinopathy . RAAS renin–angiotensin–aldosterone system, AGE advanced glycation end-product, IO intraoccular,
diabetic retinopathy 5512 end-product, IO intraoccular, EBM endothelial basal membrane, BRB blood retinal barrierGenetic aspects of the diabetic retinopathy The above mentioned risk factors are not solely responsible for susceptibility to DR. Clinical studies
diabetic retinopathy 31060 crucial part [[126]] (Fig. 3).Fig. 3Genes harboring DNA polymorphisms involved in angiogenesis during diabetic retinopathy (DR). AS angiostatin, ES endostatin, BRB blood retinal barrier, ECM extracellular matrix, • inhibitionReceptor
diabetic retinopathy 36726 production of reactive oxygen species (ROS) by mitochondria. Overproduction of ROS is associated with diabetic retinopathy (DR), thereby UCP2 gene polymorphisms can be involved in the development of this complication. rs660339
diabetic retinopathy 43301 identified by candidate gene studies have achieved widespread acceptance as a marker of high risk of diabetic retinopathy . In part, this may be because of the complexity of DR which probably has more multifactorial, polygenic
diabetic retinopathy 43640 multiple alleles or nearby SNPs have varying strengths of association or significance in relation to diabetic retinopathy . Possible explanation for this is variable association between the SNPs themselves with the causative
hyperhomocysteinemia 23921 Euro-Brazilian, Multi-ethnic, TurkishControversial findings, T allele possible increases risk of DR because of hyperhomocysteinemia [[28], [77], [107], [108]]NPYNeuropeptide Y (p. L7P)Vasoconstriction, angiogenesisrs1613972FinnishC
obesity 36317 in the promoter of the UCP1, has been shown to be associated with glucose homeostasis, adiposity and obesity , as well as changes in the body mass index (BMI) and body weight, resulting from metabolic disorders.

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