Antidiabetic Effects of Resveratrol: The Way Forward in Its Clinical Utility.

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Term Occurence Count Dictionary
obesity 3 endocrinologydiseases
diabetes mellitus 9 endocrinologydiseases
diabetic neuropathy 2 endocrinologydiseases
diabetic retinopathy 1 endocrinologydiseases
hypertriglyceridemia 1 endocrinologydiseases
metformin 1 endocrinologydiseasesdrugs

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Select Drug Character Offset Drug Term Instance
metformin 25872 colleagues demonstrated that RSV (250 mg/day for 3 months) administered along with glibenclamide and/or metformin demonstrated improvement in glycaemic parameters in diabetic patients [[16]]. The study reported improvement
Select Disease Character Offset Disease Term Instance
diabetes mellitus 761 /2016Publication date (epub): 12/2016AbstractDespite recent advances in the understanding and management of diabetes mellitus , the prevalence of the disease is increasing unabatedly with resulting disabling and life-reducing consequences
diabetes mellitus 1095 therapies have necessitated the search for novel therapeutic agents. Due to the multipathogenicity of diabetes mellitus , plant-derived compounds with proven multiple pharmacological actions have been postulated to “hold
diabetes mellitus 1663 despite the enthusiasm and widespread successes achieved with the use of resveratrol in animal models of diabetes mellitus , there are extremely limited clinical data to confirm the antidiabetic qualities of resveratrol. This
diabetes mellitus 1870 resveratrol. This review presents an update on the mechanisms of action and protection of resveratrol in diabetes mellitus , highlights challenges in its clinical utility, and suggests the way forward in translating the promising
diabetes mellitus 6845 defects in insulin secretion, activities, or both [[28]]. The two major types are insulin-dependent diabetes mellitus (IDDM-type 1) and non-insulin-dependent diabetes mellitus (NIDDM-type 2). The former is characterized
diabetes mellitus 6903 The two major types are insulin-dependent diabetes mellitus (IDDM-type 1) and non-insulin-dependent diabetes mellitus (NIDDM-type 2). The former is characterized by selective autoimmune destruction of insulin producing
diabetes mellitus 36487 large, well-controlled clinical studies to confirm the efficacy of resveratrol in the management of diabetes mellitus and gain a better insight into its biological effects in humans. In addition, the effective doses of
diabetes mellitus 37171 resveratrol in subsequent studies, we may be able to use resveratrol or its analogue to treat or prevent diabetes mellitus in humans in the nearest future.Figure 1Chemical structures of resveratrol.Figure 2Protective effects
diabetes mellitus 37309 nearest future.Figure 1Chemical structures of resveratrol.Figure 2Protective effects of resveratrol in diabetes mellitus , adapted from [[59], [64], [71], [120]–[122]].Figure 3A simplified scheme showing mechanisms of resveratrol
diabetic neuropathy 12026 clinical parameters in both type 1 and type 2 animal models of diabetic nephropathy [[25], [42], [43]]; diabetic neuropathy [[3], [44], [45]]; diabetic retinopathy [[20], [46]–[48]]; diabetes-induced hypertension [[49], [50]];
diabetic neuropathy 24122 contributing to reduction in neuroinflammation and protection against functional and behavioural deficits in diabetic neuropathy [[106]]. The anti-inflammatory property of RSV has been confirmed in diabetic animals by the downregulation
diabetic retinopathy 12065 2 animal models of diabetic nephropathy [[25], [42], [43]]; diabetic neuropathy [[3], [44], [45]]; diabetic retinopathy [[20], [46]–[48]]; diabetes-induced hypertension [[49], [50]]; diabetes-induced cardiovascular diseases
hypertriglyceridemia 40353 expression of inflammatory biomarkers, AMPK, and acetyl-CoA carboxylase[[116]]Overweight/obese men with mild hypertriglyceridemia 82 weeks (1000 mg/day for 1st week followed by 2000 mg/day for 2nd week)(i) No effect on insulin
obesity 4548 biological activity.RSV has elicited beneficial effects in cardiovascular disorders, cancer, diabetes, obesity , amyloidogenesis, and others [[9]–[13]]. Some of these beneficial effects occurred via mechanisms
obesity 7444 makeup, and environmental factors are responsible for pancreatic islets destruction [[30]] whereas obesity , nutritional disorders, hypertension, lifestyle habits, and genetic/hereditary factors have been implicated
obesity 16999 conditions [[81]]. In experimental animals, activation of SIRT1 was reported to offer protection against obesity and insulin resistance by positively regulating the secretion of insulin [[82]]. The regulation of insulin

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