Cytotoxic T-lymphocyte-associated protein 4 +49A/G polymorphisms contribute to the risk of type 1 diabetes in children: An updated systematic review and meta-analysis with trial sequential analysis.

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diabetes mellitus 3 endocrinologydiseases
type 1 diabetes mellitus 1 endocrinologydiseases

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diabetes mellitus 2744 cytotoxic T-lymphocyte associated protein 4(CTLA-4) gene, which has been mapped to the insulin-dependent diabetes mellitus (IDDM) 12 locus (2q33), encodes a T-cell-specific transmembrane co-receptor [[6]]. The CTLA-4 gene is
diabetes mellitus 3390 in the development of Graves’ disease (GD) [[9]], systemic lupus erythematosus (SLE) [[10]], and diabetes mellitus [[11]]. Nistico et al. [[12]] first found a strong association between T1D risk and CTLA-4 +49A/G polymorphisms
diabetes mellitus 22740 up to March 30, 2016. The following search terms were used: T1DM or T1D or type 1 diabetes or type 1 diabetes mellitus in combination with polymorphism or polymorphisms in combination with CTLA4 or Cytotoxic T-Lymphocyte
type 1 diabetes mellitus 22733 published up to March 30, 2016. The following search terms were used: T1DM or T1D or type 1 diabetes or type 1 diabetes mellitus in combination with polymorphism or polymorphisms in combination with CTLA4 or Cytotoxic T-Lymphocyte

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