Neuronal Changes in the Diabetic Cornea: Perspectives for Neuroprotection.

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Term Occurence Count Dictionary
diabetic autonomic neuropathy 1 endocrinologydiseases
diabetic neuropathy 11 endocrinologydiseases
diabetic retinopathy 2 endocrinologydiseases
hyperglycemia 2 endocrinologydiseases
obesity 1 endocrinologydiseases
diabetes mellitus 1 endocrinologydiseases

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diabetes mellitus 11042 [[61]]Misra et al. also described a clinical application of in vivo confocal microscopy in patients with diabetes mellitus type 1 [[62]]. They measured the corneal nerve parameters in type 1 diabetics and controls and confirmed
diabetic autonomic neuropathy 10767 assess progression of diabetic neuropathy [[60]]. In their recent study it was shown that patients with diabetic autonomic neuropathy had a progressive and significant reduction of corneal nerve fiber density, branch density, and length
diabetic neuropathy 867 diabetic individuals, and the findings suggest that corneal neuropathy might be an early indicator of diabetic neuropathy . Additionally, the recent findings for neuroprotective and regenerative therapy for diabetic keratopathy
diabetic neuropathy 4422 have provided strong evidence that glycation plays an important role in the pathogenesis of retinal diabetic neuropathy with the triggering of different mechanisms that result in neuronal dysfunction [[21], [22]]. Obrosova
diabetic neuropathy 4698 poly(ADP-ribose) polymerase activation were fundamental mechanisms that play a role in the pathogenesis of diabetic neuropathy [[23]]. Byun et al. confirmed that poly(ADP-ribose) polymerase inhibition prevented the loss of epithelial
diabetic neuropathy 4972 healing. They concluded that poly(ADP-ribose) polymerase activation played a role in the pathogenesis of diabetic neuropathy [[24]].The results of a recent study have shown that one of the functions of corneal nerve fibers is
diabetic neuropathy 7709 They also suggested that diabetes disrupted the neural communications of dendritic cells resulting in diabetic neuropathy and impairs sensory nerve regeneration in the cornea. Thus, dendritic cell-based therapy should be explored
diabetic neuropathy 7841 sensory nerve regeneration in the cornea. Thus, dendritic cell-based therapy should be explored for diabetic neuropathy [[37]].A study of the effects of neuropathy showed that the diabetes-induced denervation of the cornea
diabetic neuropathy 9403 method for quantifying the damage and repair of corneal sensory nerves that can serve as markers for diabetic neuropathy . Thus, Rosenberg et al. using confocal microscopy found decreased corneal sensitivity together with
diabetic neuropathy 10685 [59]].Tavakoli et al. suggested using confocal microscopy in longitudinal studies to assess progression of diabetic neuropathy [[60]]. In their recent study it was shown that patients with diabetic autonomic neuropathy had a progressive
diabetic neuropathy 11417 neuropathy and systemic neuropathy. They concluded that corneal neuropathy might be an early indicator of diabetic neuropathy because it preceded other clinical and electrophysiology tests of neuropathy [[62]]. Also Pritchard
diabetic neuropathy 18681 recently [[88]].6. ConclusionsImpaired corneal innervation in diabetes is an important early indicator of diabetic neuropathy . The decrease in corneal sensitivity with a longer duration of diabetes is correlated with the severity
diabetic neuropathy 18938 investigations on mechanisms of corneal nerve damage and establishment of pathogenetic-orientated therapy for diabetic neuropathy should be the main focus of future research.Table 1Neurotrophic factors in the cornea.Growth factorHealthy
diabetic retinopathy 1506 was recently demonstrated that retinal neuronal components were associated with the pathogenesis of diabetic retinopathy [[2], [3]], and the neuronal degeneration in the retina may be dependent on the mitochondrial- and caspase-dependent
diabetic retinopathy 1745 cell-death pathway [[4]]. It is known that neuronal abnormalities directly affect visual function in diabetic retinopathy , and those neuronal changes are probably also the reason for diabetic keratopathy, as cornea is one
hyperglycemia 13837 and progression of peripheral neuropathy and nerve structural damage in the cornea with or without hyperglycemia [[72]].Diabetic neurotrophic keratopathy, a manifestation of diabetic polyneuropathy, also plays a significant
hyperglycemia 18248 neurite outgrowth in isolated trigeminal sensory neurons. This overcame the detrimental effects of hyperglycemia by stimulating corneal nerve regeneration by decreasing the expression of one of its target genes, NOX4
obesity 13707 caused an elevated level of glucose in the fasting blood, and they demonstrated that the diet-induced obesity led to the development and progression of peripheral neuropathy and nerve structural damage in the cornea

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