Controversies about sugars: results from systematic reviews and meta-analyses on obesity, cardiometabolic disease and diabetes

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diabetes mellitus 1 endocrinologydiseases
metabolic syndrome 5 endocrinologydiseases
obesity 19 endocrinologydiseases

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Select Drug Character Offset Drug Term Instance
Select Disease Character Offset Disease Term Instance
diabetes mellitus 26503 disease burdens using best available estimates of the association of each risk factor with obesity, diabetes mellitus , cardiovascular disease and cancers, and combined it with age-, sex- and cause-specific mortality using
metabolic syndrome 2649 important risk factor for the development of obesity [[1]], cardiometabolic disease [[2]] including metabolic syndrome [[3]] and diabetes [[4]]. Leading organizations including the World Health Organization (WHO) [[5]]
metabolic syndrome 7906 in the liver as it bypasses the main rate-limiting steps of glycolysis [[29]]. A new hypothesis of metabolic syndrome that involves fructose-induced increases in uric acid via the depletion of intracellular adenosine triphosphate
metabolic syndrome 18164 association between SSBs and incident diabetes [[56]]. Significant relationship of SSBs also exists with metabolic syndrome [[57]], hypertension [[58]], CHD [[59], [60]], stroke [[61]] and gout [[62]].Meanwhile, pooled analyses
metabolic syndrome 28555 relatively modest. For example, pooled relative risk (RR) for SSBs with cardiometabolic diseases including metabolic syndrome (RR = 1.20, highest vs. lowest quantile) [[57]], diabetes (RR = 1.18, per serving increase) [[56]],
metabolic syndrome 56635 possibly due to higher fibre and protein content. Another randomized study of 46 participants with metabolic syndrome following the same protocol over 6 months showed similar results [[146]]. In this study, those on the
obesity 117 Journal of NutritionControversies about sugars: results from systematic reviews and meta-analyses on obesity , cardiometabolic disease and diabetesTauseef A. KhanJohn L. SievenpiperPublication date (epub): 11/2016Publication
obesity 410 /2016AbstractFructose-containing sugars are a focus of attention as a public health target for their putative role in obesity and cardiometabolic disease including diabetes. The fructose moiety is singled out to be the primary
obesity 2594 that are ‘added’ to our diets are alleged to be an important risk factor for the development of obesity [[1]], cardiometabolic disease [[2]] including metabolic syndrome [[3]] and diabetes [[4]]. Leading
obesity 3095 was just in recent past that saturated fat was of public health concern for its adverse effects on obesity and cardiovascular disease—though the blame has now been shifted to fructose-containing sugars [[7],
obesity 3324 paper we aim to present a review of the highest level of evidence on dietary sugars and their effect on obesity and cardiometabolic disease including important considerations that sheds light on some of the controversies
obesity 4595 cardiovascular disease [[11]].Dietary sugars came into forefront again in 2004 when Dr. George Bray, an eminent obesity researcher, published an ecological study that showed a parallel rise between overweight/obesity and
obesity 4692 eminent obesity researcher, published an ecological study that showed a parallel rise between overweight/ obesity and fructose-containing sugars in the USA [[12]]. In an ecological study, the units of analysis are
obesity 6939 harms of sugars is much louder and dietary sugars are now squarely blamed for the rising epidemic of obesity and chronic disease in the Western nations, and with some even drawing strong parallels with tobacco
obesity 9729 honey. In parallel, ecological observations that link increase in fructose availability with increase in obesity , diabetes and hypertension [[3], [12], [37]] are offered as compelling proof that these mechanisms are
obesity 11247 restriction in dietary sugars intake. Is this recommendation based on evidence of harm in relation to obesity , diabetes and cardiovascular disease? A careful review of these guidelines reveals that most of these
obesity 13022 cohort studies) consumption is associated with adverse health effects including heart disease, stroke, obesity , diabetes, high blood pressure, cancer to support a recommendation of <10% dietary intake of energy
obesity 13233 from sugars [[43]]. Similarly, using evidence from prospective cohort studies of SSB intake on risk of obesity and diabetes, the CDA also submitted a position statement in September 2015 recommending <10% calories
obesity 15017 to be answered is: is there something special about fructose metabolism that increases the risk of obesity and chronic disease, or is the harm is related just to the excess calories it provides. In this review,
obesity 16622 strongest evidence from observational studies for assessing the relation of dietary sugars exposure to obesity , diabetes and cardiovascular disease. While this makes prospective cohort studies a good place to look
obesity 17780 prospective cohort studies showed a significant association between SSBs and the risk of overweight/ obesity in children and weight gain in adults [[49]]. Another meta-analysis of 22 prospective cohort studies
obesity 26494 national disease burdens using best available estimates of the association of each risk factor with obesity , diabetes mellitus, cardiovascular disease and cancers, and combined it with age-, sex- and cause-specific
obesity 26795 these estimates included both direct effects on disease burden but also indirect effects via increased obesity . When looking at the ranking of the top 15 dietary and physical activity factors, high intake of SSBs
obesity 29806 are several fold higher than the risk estimates seen with SSB intake, the analogy that SSBs are to obesity and diabetes as cigarette smoking to lung cancer [[27], [103], [104]] does not stand. Thus, the evidence
obesity 58625 ‘low-fat’ food was not seen, and instead, we saw an unprecedented increase in incidence of overweight/ obesity [[149]] and diabetes [[150]].If a similar approach is taken by the industry who producing ‘low-sugar’

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