Lung adenocarcinoma expressing receptor for advanced glycation end-products with primary systemic AL amyloidosis: a case report and literature review.

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amyloidosis 26 endocrinologydiseases
bortezomib 1 endocrinologydiseasesdrugs
dexamethasone 2 endocrinologydiseasesdrugs

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bortezomib 7391 levels were not responsive to treatment. The patient died after 3 months despite dexamethasone and bortezomib treatment in another hospital.DiscussionRAGE is a multiligand receptor that binds structurally diverse
dexamethasone 7128 poor prognosis rather than that expected with early-stage lung adenocarcinoma and was treated with dexamethasone (20 mg/day) and diuretics. The oedema, mainly due to the nephrotic syndrome with severe proteinuria,
dexamethasone 7373 natriuretic peptide levels were not responsive to treatment. The patient died after 3 months despite dexamethasone and bortezomib treatment in another hospital.DiscussionRAGE is a multiligand receptor that binds structurally
Select Disease Character Offset Disease Term Instance
amyloidosis 118 CancerLung adenocarcinoma expressing receptor for advanced glycation end-products with primary systemic AL amyloidosis : a case report and literature reviewShouichi OkamotoShinsaku TogoIchiro NagataKazue ShimizuYoshika KoinumaYukiko
amyloidosis 771 outcome in lung cancer patients. We report a rare case of primary systemic amyloid light-chain (AL) amyloidosis in biopsy-proven multiple organs with early-stage non-small cell lung cancer (NSCLC) that displayed
amyloidosis 1751 gastric and duodenal mucosa, cardiac muscle, and bone marrow led to a diagnosis of primary systemic AL amyloidosis with nephrotic syndrome and cardiomyopathy. In addition, RAGE was detected in lung tumour tissues surrounded
amyloidosis 2157 RAGE-expressing cancer cells. Lung adenocarcinoma with RAGE expression may be a complication of underlying amyloidosis .BackgroundThe incidence of systemic amyloidosis in patients with cancer is very rare and has been estimated
amyloidosis 2205 RAGE expression may be a complication of underlying amyloidosis.BackgroundThe incidence of systemic amyloidosis in patients with cancer is very rare and has been estimated to be between 0.1% and 0.4% among all cancers
amyloidosis 2913 of cancers [[3], [4]]. Herein, we report on a rare case of primary systemic amyloid light-chain (AL) amyloidosis in biopsy-proven multiple organs with early-stage NSCLC that displayed strong staining for RAGE in the
amyloidosis 6839 componentFinally, the case was diagnosed as lung adenocarcinoma, Stage IA (cT1bN0M0), and primary systemic AL amyloidosis with nephrotic syndrome and cardiomyopathy.Because the patient displayed rapidly worsening edema and
amyloidosis 6960 nephrotic syndrome and cardiomyopathy.Because the patient displayed rapidly worsening edema and cardiac amyloidosis with elevated brain natriuretic peptide, she was given a poor prognosis rather than that expected with
amyloidosis 8478 bone marrow (Fig. 2c, d, e). We confirmed RAGE staining in lung cancer tissues without comorbidity of amyloidosis by applying immunohistochemical analysis in randomly selected biopsy samples of lung cancer, including
amyloidosis 10388 In the present patient, the onset of lung cancer appeared to match mostly with that of systemic AL amyloidosis with increasing SFLC, regarded as the precursor form of amyloid protein [[18]]. This case was not AA
amyloidosis 10501 with increasing SFLC, regarded as the precursor form of amyloid protein [[18]]. This case was not AA amyloidosis but systemic AL amyloidosis; thus, SAA levels were within normal limits.The relationship between cancer
amyloidosis 10529 regarded as the precursor form of amyloid protein [[18]]. This case was not AA amyloidosis but systemic AL amyloidosis ; thus, SAA levels were within normal limits.The relationship between cancer and amyloidosis is still
amyloidosis 10621 systemic AL amyloidosis; thus, SAA levels were within normal limits.The relationship between cancer and amyloidosis is still unknown, as well as the relevance of amyloidosis as a paraneoplastic syndrome induced by lung
amyloidosis 10679 limits.The relationship between cancer and amyloidosis is still unknown, as well as the relevance of amyloidosis as a paraneoplastic syndrome induced by lung cancers. However, 10 of 12 case reports, including the
amyloidosis 10886 the present case, showed the diagnosed period of lung cancer to be the same as or prior to that of amyloidosis (Table 1) [[19]–[29]]. These clinical time courses suggest the prior onset of lung cancer may contribute
amyloidosis 11120 deposition of amyloid through paraneoplastic mechanisms. In the present case, the deterioration of cardiac amyloidosis directly led to death, as a poorer prognostic factor than early lung cancer itself. Generally, RAGE
amyloidosis 11524 early-stage lung cancer (Fig. 2b, f).Table 1Clinicopathological features of lung cancer patients with amyloidosis Author, yearAge(y)/sexCancer type and stageAmyloid organ involvementTypePrior diagnosisaTreatment for
amyloidosis 11844 cancerRadiotherapyPulmonary infectionMeyrier et al. 1985 [[20]]59/MSCC, TbN1MxA, K, SPAALung cancerCCRTRenal failure due to amyloidosis Focan et al. 1985 [[21]]70/MSCC, EarlyBM, Digestive tractN/AUnknownNonePulmonary infectionRichmond et
amyloidosis 12048 infectionRichmond et al. 1990 [[22]]72/MSCC, EarlyMultiple organsAASameNonePeritonitis and Renal failure due to amyloidosis Benharroch et al. 1992 [[23]]51/FAC, N/AFALUnknownNoneRenal failure due to systemic sclerosisPartidge
amyloidosis 12665 IIIBKAALung cancerChemotherapyN/AOur case 201671/FAC, Stage IAD, H, K, L, STALSameNoneHeart failure due to amyloidosis A adrenal gland, AA amyloid A amyloidosis, AC adenocarcinoma, AL amyloid light-chain amyloidosis, BM
amyloidosis 12706 201671/FAC, Stage IAD, H, K, L, STALSameNoneHeart failure due to amyloidosisA adrenal gland, AA amyloid A amyloidosis , AC adenocarcinoma, AL amyloid light-chain amyloidosis, BM bone marrow, C colon, CCRT concurrent chemoradiotherapy,
amyloidosis 12761 to amyloidosisA adrenal gland, AA amyloid A amyloidosis, AC adenocarcinoma, AL amyloid light-chain amyloidosis , BM bone marrow, C colon, CCRT concurrent chemoradiotherapy, D duodenum, F female, H heart, K kidney,
amyloidosis 13111 cancer, SP spleen, ST stomach, y yearsa ‘Same’ refers to a diagnosis given at the same time as amyloidosis Thus, the RAGE positivity of lung cancer cells in this case suggests an interaction between amyloid-containing
amyloidosis 13315 amyloid-containing tissues and RAGE-expressing cancer cells, which may progress both lung cancer and amyloidosis . Further study is warranted to investigate this association.ConclusionWe describe a rare case of amyloid
amyloidosis 13487 association.ConclusionWe describe a rare case of amyloid receptor-positive lung adenocarcinoma with systemic AL amyloidosis . Clinicians should be aware that RAGE-positive lung cancer may be a complication of underlying amyloidosis
amyloidosis 13594 amyloidosis. Clinicians should be aware that RAGE-positive lung cancer may be a complication of underlying amyloidosis that could impact more severely on the prognosis of the patient than the cancer itself

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