Impact of Mediterranean diet on metabolic syndrome, cancer and longevity.

Existing Reviews

Please note, new claims can take a short while to show up.

No claims yet.

Annotation Summary

Term Occurence Count Dictionary
Insulin 2 endocrinologydiseasesdrugs
glucose intolerance 1 endocrinologydiseases
osteoporosis 3 endocrinologydiseases
type 2 diabetes mellitus 2 endocrinologydiseases
diabetes mellitus 2 endocrinologydiseases
hyperhomocysteinemia 1 endocrinologydiseases
hyperinsulinemia 1 endocrinologydiseases
hyperuricemia 1 endocrinologydiseases
metabolic syndrome 16 endocrinologydiseases
obesity 53 endocrinologydiseases

Graph of close proximity drug and disease terms (within 200 characters).

Note: If this graph is empty, then there are no terms that meet the proximity constraint.

Review

Having read the paper, please pick a pair of statements from the paper to indicate that a drug and disease are related.

Select Drug Character Offset Drug Term Instance
Insulin 4810 is the basis of metabolic disturbances, such as insulin resistance, dyslipidemia and hyperuricemia. Insulin resistance is the “core” of the MetS and abdominal obesity plays a central role in this syndrome.MetS
Insulin 7748 definitions of Metabolic SyndromeWH0 (1998) [[15]]NCEP/ATP III (2001-2005) [[257]]IDF (2005) [[258]] Insulin resistance or diabetes or impaired glucose tolerance or impaired fasting glucose, plus two of these
Select Disease Character Offset Disease Term Instance
diabetes mellitus 5035 characterized by dyslipidemia and arterial hypertension, which are associated with increased risk of type 2 diabetes mellitus (T2DM) and cardiovascular diseases (CVD) [[9]]. The relationship between obesity and T2DM is so strong
diabetes mellitus 9189 Federation NCEP ATP III: National Cholesterol Education Program's Adult Treatment Panel III report T2DM: type 2 diabetes mellitus WHO: World Healt OrganizationMain definitions drawn up by the WHO, NCEP/ ATP III and IDF of MetS recognized
glucose intolerance 6058 currently defined “Metabolic Syndrome”. Reaven noticed a close link between risk factors of CVD ( glucose intolerance , hyperinsulinemia, high serum triglycerides, low serum high-density lipoprotein cholesterol) and arterial
hyperhomocysteinemia 29216 body fat ratio compared to T (-) carriers [[105]]. The increased CV risk for T (+) carriers is due to hyperhomocysteinemia related in turn to lack of 5-methyltetrahydrofolate, necessary to methylate homocysteine (Hcy) into
hyperinsulinemia 6079 “Metabolic Syndrome”. Reaven noticed a close link between risk factors of CVD (glucose intolerance, hyperinsulinemia , high serum triglycerides, low serum high-density lipoprotein cholesterol) and arterial hypertension.
hyperuricemia 4795 inflammatory state that is the basis of metabolic disturbances, such as insulin resistance, dyslipidemia and hyperuricemia . Insulin resistance is the “core” of the MetS and abdominal obesity plays a central role in this
metabolic syndrome 49 Title: OncotargetImpact of Mediterranean diet on metabolic syndrome , cancer and longevityNicola Di DanieleAnnalisa NoceMaria Francesca VidiriEleonora MoriconiGiulia MarroneMargherita
metabolic syndrome 844 symbolizes a major public health problem. Overweight and obesity are associated to the occurrence of the metabolic syndrome and to adipose tissue dysfunction. The adipose tissue is metabolically active and an endocrine organ,
metabolic syndrome 1109 inflammatory state and ectopic fat depositions. The Mediterranean Diet represents a possible therapy for metabolic syndrome , preventing adiposopathy or “sick fat” formation.The Mediterranean Diet exerts protective effects
metabolic syndrome 1928 this review are to evaluate the impact of Mediterranean Diet on onset, progression and regression of metabolic syndrome , cancer and on longevity.INTRODUCTIONObesity and metabolic syndrome (MetS) showed a significant increase
metabolic syndrome 1996 onset, progression and regression of metabolic syndrome, cancer and on longevity.INTRODUCTIONObesity and metabolic syndrome (MetS) showed a significant increase in the last decades, becoming a public health problem due to high
metabolic syndrome 31541 intervention and nutrients dose change according to genetic polymorphisms.Impact of mediterranean diet on metabolic syndrome and obesityThe Seven Country Study, an International Cooperative Study on coronary heart disease epidemiology,
metabolic syndrome 53663 years7447-------55-80PREDIMED randomized trial analyzed the effect of Mediterranean Diet on incidence and reversion of metabolic syndrome .The Mediterranean Diet with extra-virgin oil after a median follow-up of 4.8 years, had reduced by 30%
metabolic syndrome 53980 diet, either supplemented with extra virgin olive oil or nuts, was not associated with the onset of metabolic syndrome but only with its regression.De Lorenzo A, et al.-------Italy2001Obese Italian women without obesity-related
metabolic syndrome 61400 lipoperoxides and 8-epi prostaglandin-F2alpha levels.Grosso G, et al.-------Italy2014Subjects with or without metabolic syndrome 1 year1889-------Mean 50.2The study investigated the relationship between the beverages containing caffeine
metabolic syndrome 61548 study investigated the relationship between the beverages containing caffeine and the components of metabolic syndrome .Coffee and tea consumption was significantly associated with reduced odds of MS; however, no direct
metabolic syndrome 61781 between caffeine intake and MS components was evaluated.Basu A, et al.-------US2010Men and women with metabolic syndrome 8 weeks48-------50± 3The study aimed to evaluate the effects of blueberry supplementation on features
metabolic syndrome 61905 weeks48-------50± 3The study aimed to evaluate the effects of blueberry supplementation on features of metabolic syndrome , lipid peroxidation, and inflammation in obese men and women.The blueberry supplementation decreases
metabolic syndrome 62194 concentration and lipid profiles were not affected.Kolehmainen M et al.-------Finland2012Subjects with metabolic syndrome 8 weeks27-------53± 6The aim was to study the impact of bilberries on inflammation and gene expression
metabolic syndrome 62579 demonstrating a decrease of cardiometabolic risk in long term.Basu A et al.-------US2010Subjects with metabolic syndrome 8 weeks27-------47 ±3The aim was to verify if a freeze-dried strawberry supplementation can improve
metabolic syndrome 62803 pressure, impaired glucose, dyslipidemia, or circulating adhesion molecules in obese subjects with metabolic syndrome .A short-term supplementation with 4 cups of freeze-dried strawberry beverage improve selected atherosclerotic
metabolic syndrome 63021 atherosclerotic risk factors, including dyslipidemia and circulating adhesion molecules in subjects with metabolic syndrome .Legend Table 4: CVD: cardiovascular diseases MHMD: moderately hypocaloric Mediterranean Diet LDL:
obesity 796 1/2017Publication date (epub): 11/2016AbstractObesity symbolizes a major public health problem. Overweight and obesity are associated to the occurrence of the metabolic syndrome and to adipose tissue dysfunction. The adipose
obesity 1364 without baseline of chronic diseases. Recent studies have demonstrated a relationship between cancer and obesity . In the US, diet represents amount 30-35% of death causes related to cancer. Currently, the cancer is
obesity 2191 health problem due to high hospitalization rates, treatment costs and impaired quality of life.Both obesity that MetS are characterized by insulin resistance that expose the patients to an increased risk of cardiovascular
obesity 3140 a protective factor against the onset of various types of cancer, cardiovascular disease, aging and obesity . As shown by the Epic (European Prospective Investigation into Cancer and Nutrition) study, the MD is
obesity 3443 nutrients that are found in abundance in the Mediterranean diet have anti-cancer, anti-inflammatory, anti- obesity properties and contribute together to the maintenance of health status. The anti-tumor effects of the
obesity 3932 costs.MEDITERRANEAN DIET, METABOLIC SYNDROME (METS) AND OBESITYDefinition and classification of MetsOverweight and obesity are highly prevalent worldwide. One billion people in the world are overweight and 300 million are considered
obesity 4208 approximately 2 billion people will be overweight and 1,12 billion obese [[4]]. In the United States, abdominal obesity has tripled during the past 40 years [[5]]. More than 25% of the US population can be classified as
obesity 4466 increased from 34.3% to 38.5% during the past 15 years [[7], [8]]. Given the prevalence of the phenomenon, obesity is considered an important public health problem, with a strong impact on health status, economy and
obesity 4873 resistance, dyslipidemia and hyperuricemia. Insulin resistance is the “core” of the MetS and abdominal obesity plays a central role in this syndrome.MetS is characterized by dyslipidemia and arterial hypertension,
obesity 5126 of type 2 diabetes mellitus (T2DM) and cardiovascular diseases (CVD) [[9]]. The relationship between obesity and T2DM is so strong that the new term “diabesity” has been introduced. It is a global pandemic
obesity 5452 expenditure, with the result of weight gain. In recent years there has been an increase in the incidence of obesity in young people, with the result that T2DM and MetS are not exclusive to adulthood but are increasingly
obesity 5690 [[10]].In addition, several types of cancers, including uterine, breast, colon, prostate and kidney are obesity driven [[8], [9]]. Studies indicate that, over the past decade, 25% of all cancers could be prevented
obesity 5824 indicate that, over the past decade, 25% of all cancers could be prevented by reducing the rate of obesity [[13]–[15]].Several definitions for MetS have been proposed. In 1988, Reaven first spoke of “the
obesity 7127 define MetS. This study group gave less attention to the criteria albuminuria and focused on abdominal obesity expressed as waist circumference. In particular, IDF considers waist circumference as essential criteria
obesity 7904 tolerance or impaired fasting glucose, plus two of these conditionsAt least 3 of the following:Abdominal obesity defined as waist circumference ≥ 94 cm in men and ≥80 cm in womenPlus at least two of the following
obesity 10827 both the state vascular and the individual susceptibility to organ damage [[26]–[31]].Phenotypes of obesity Obesity can be categorised according to four phenotypes: 1) Normal weight obese (NOW) [[32]]; 2) Metabolically
obesity 11136 Metabolically unhealthy obese (MUO) or “at risk obese” with MetS [[35]]. Furthermore, the sarcopenic obesity was described and related to all these obesity phenotypes [[36]]. NWO syndrome was defined firstly by
obesity 11183 obese” with MetS [[35]]. Furthermore, the sarcopenic obesity was described and related to all these obesity phenotypes [[36]]. NWO syndrome was defined firstly by De Lorenzo et al, in order to indicate subjects
obesity 11554 and chronic inflammatory status and they have higher risk of cardio-metabolic diseases and sarcopenic obesity [[37]]. The inflammation is explained by the presence of single nucleotides polymorphisms (SNPs) in
obesity 11976 [[40]] and in G/A -308 Tumor Necrosis Factor-alpha (TNF-α). The latter is associated to sarcopenic obesity [[41]]. MONW subjects have a normal weight but metabolic alterations typical of MetS (such as high blood
obesity 12471 individuals. In fact, 20-30% of obese adults do not show the metabolic complication associated with obesity . MHO individuals have high insulin-sensitivity, normal blood pressure, no signs of chronic inflammation
obesity 12711 Therefore, the inflammation is correlated to increasing of adipose tissue but is not always linked to obesity [[45], [46]]. MUO, are also called “at risk” obese subjects. They are obese for both anthropometric
obesity 13456 leading to a loss of muscle mass and muscle weakness [[50]]. Schrager et al demonstrated that sarcopenic obesity was directly related to higher levels of IL-6, CRP, IL-1 receptor antagonist and IL-7; consequently
obesity 13648 IL-7; consequently these cytokines were involved in both the development and progression of sarcopenic obesity [[51]]. The identification of obesity phenotypes can allow early detection the subjects at risk to develop
obesity 13686 involved in both the development and progression of sarcopenic obesity [[51]]. The identification of obesity phenotypes can allow early detection the subjects at risk to develop the MetS in order to carry out
obesity 15311 even if further analysis are needed to explain its ability to turn into WAT and its correlation with obesity [[56]]. The main role of WAT is energy and fat storage, however, it is also considered an endocrine
obesity 15709 age, the adipokines released by WAT are associated with the major cardio-metabolic complications of obesity (such as IR, elevated arterial blood pressure, dyslipidemia, T2DM and atherosclerosis).During life,
obesity 18421 This process is the base of “meta-inflammation”, a chronic low-grade inflammatory state caused by obesity [[68]]. The lipid storage capacity decrease inhibits preadipocytes differentiation and increases lipolysis.
obesity 21185 resistin, visfatin, omentin, leptin, PAI-1 and angiotensinogen. EAT is also associated with T2DM and obesity [[81]]. Under physiological conditions, the EAT plays a cardio-protective role through the local secretion
obesity 23606 genetic profile in order to reduce the risk to onset disease. The relationship between nutrigenetics and obesity , MetS and T2DM is largely based on data relating to dietary fat [[87]–[89]]. Sedentary lifestyle behaviour
obesity 23820 behaviour and a greater availability by high-calorie foods, in particular high fat food, are associated to obesity and CVD. The “thrifty genes” play a central role in the development of obesity and metabolic disorders.
obesity 23903 are associated to obesity and CVD. The “thrifty genes” play a central role in the development of obesity and metabolic disorders. In the past, these genes promoted fat deposition as energy storage during times
obesity 24165 environment of physical inactivity and excessive caloric consumption, the thrifty genes are associated to obesity and T2DM [[90], [91]]. Several studies support the interaction between genes and environment. The different
obesity 24454 code base of a gene. They are very frequent: 1 SNP for 1,91 Kb DNA sequence and 5% of all cases of obesity and diabetes has been associated with monogenic disorders. The mutated genes, related to obesity, include
obesity 24551 of obesity and diabetes has been associated with monogenic disorders. The mutated genes, related to obesity , include leptin (LEP), leptin receptor (LEPR), pro-opiomelanocortin (POMC) and melanocortin-4 receptor
obesity 24764 (MC4R) [[92]]. Genome-wide association studies (GWAS) have evaluated susceptibility genes of T2DM and obesity . In particular, Calpain 10 (CAPN10), that encodes cysteine protease calpain 10, has been the first identified
obesity 25051 polymorphism (SNPs) are associated with T2DM risk: transcription factor 7-like 2 (TCF7L2) and fat mass and obesity -associated (FTO) gene on chromosome 16. TCF7L2 polymorphisms is related to high risk of dyslipidemia
obesity 25327 FTO gene (FTO rs9939609 mutation) is associated to 3 kg heavier and had 1,7 fold increased risk of obesity than the homozygous non-risk allele carriers [[94]]. Actually, FTO rs9939609 SNP is considered one of
obesity 25486 [[94]]. Actually, FTO rs9939609 SNP is considered one of the most important gene variants predisposing to obesity [[95]] and the LIPGENE-SU.VI MAX study showed that FTO rs9939609 is also associated with overweight
obesity 25610 LIPGENE-SU.VI MAX study showed that FTO rs9939609 is also associated with overweight and abdominally obesity [[96]].Numerous genes are also linked to an increased susceptibility to dyslipidemia, particularly peroxisome
obesity 25994 action. The most prevalent SNPs variants of PPARγ gene identified is the Pro12Ala, correlated to T2DM, obesity , and other clinical disorders [[97], [98]]. Patients with T2DM carrying the Pro12Ala polymorphism have
obesity 26120 clinical disorders [[97], [98]]. Patients with T2DM carrying the Pro12Ala polymorphism have higher risk of obesity than non-carriers although the same energy intake, perhaps secondary to a better insulin sensitivity
obesity 27115 whereas a high n-3 or low n-6 PUFA background reduces the likelihood of developing MetS [[101]]. Both obesity and the MetS are characterized by a low-grade inflammatory state that causes or exacerbates their co-morbidities.
obesity 31564 dose change according to genetic polymorphisms.Impact of mediterranean diet on metabolic syndrome and obesity The Seven Country Study, an International Cooperative Study on coronary heart disease epidemiology, promoted
obesity 47510 properties and insulin-sensitizing [[151]]. Thanks its characteristics mitigates inflammation related to obesity . Ghavipour et al. have highlighted that daily supplementation with one glass of tomato juice decreases
obesity 54092 syndrome but only with its regression.De Lorenzo A, et al.-------Italy2001Obese Italian women without obesity -related complications or other diseases2 months19-------32±4The study evaluated the efficacy and the
obesity 64960 response [[177]]. Among there, NF-kB is considered the crucial regulator in tumorigenesis, linking ageing, obesity , inflammation, and cancer [[178]].Cancer cell shows a clear altered metabolism, with distinct usage
obesity 66114 [[236]].Noto et al. have demonstrated that, in a Mediterranean population, metabolic disturbances ( obesity and MetS) are predictive of cancer in a 25 years follow up [[237]]. Epidemiological studies assessed
obesity 66320 assessed that 640 million adults in 2014 and 110 million children and adolescents in 2013 were obese. The obesity -related cancer represents up to 9% of cancer among women in North America, Europe and the Middle East.
obesity 66500 America, Europe and the Middle East. In 2013, 4.5 million deaths worldwide were related to overweight and obesity [[238]]. The International Agency for Research on Cancer (IARC) working group concluded that excess
obesity 66932 particular, cancer's risk increased from 1.2 to 1.5 in overweight individuals and from 1.5 to 1.8 in obesity people, especially for colon, gastric cardia, liver, gallbladder, pancreas and kidney cancers, while
obesity 69838 latter result is very interesting as unresolved inflammation, unrelated to infections, observed in obesity , can contribute to carcinogenesis as observed in Barrett's metaplasia, chronic pancreatitis or esophagitis
obesity 73229 by different pathways (through mechanisms of down-regulation, balance and up-regulation) preventing obesity , cancer and age-related diseases, in which inflammation has an important pathological role [[240]].MEDITERRANEAN
osteoporosis 28722 demonstrated that T (+) carriers in C677T MTHFR polymorphism have higher cardiovascular disease risk, osteoporosis and sarcopenia. In particular, the authors examined the impact of the C677T MTHFR gene polymorphism
osteoporosis 29452 methionine.Hyperhomocysteinemia is also associated to neural tube defects [[106]], Alzheimer's disease [[107]] and osteoporosis . The MTHFR polymorphism effects on bone mineral density (BMD) depend on folate status. The mechanism
osteoporosis 78078 osteoblastogenesis and inhibits the main adipogenesis regulators, as PPAR-γ2, lowering the incidence of osteoporosis [[285]]. Furthermore, the phenolic compound oleocantale has the same anti-inflammatory effects of ibuprofen,
type 2 diabetes mellitus 5028 characterized by dyslipidemia and arterial hypertension, which are associated with increased risk of type 2 diabetes mellitus (T2DM) and cardiovascular diseases (CVD) [[9]]. The relationship between obesity and T2DM is so strong
type 2 diabetes mellitus 9182 Federation NCEP ATP III: National Cholesterol Education Program's Adult Treatment Panel III report T2DM: type 2 diabetes mellitus WHO: World Healt OrganizationMain definitions drawn up by the WHO, NCEP/ ATP III and IDF of MetS recognized

You must be authorized to submit a review.