Diabetes in pregnancy and infant adiposity: systematic review and meta-analysis.

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Annotation Summary

Term Occurence Count Dictionary
childhood obesity 1 endocrinologydiseases
diabetes mellitus 3 endocrinologydiseases
obesity 4 endocrinologydiseases

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Select Drug Character Offset Drug Term Instance
Select Disease Character Offset Disease Term Instance
childhood obesity 25017 participants in Belfast (one of 15 study centres),[54] nor have follow-up studies shown reduced early childhood obesity following treatment of GDM,[55][56] though intriguingly female offspring had lower fasting glucose concentrations.[55]
diabetes mellitus 2934 increasing[1][2] and currently affects up to 5% of women in the UK. Approximately 87.5% of cases are gestational diabetes mellitus (GDM), 7.5% type 1 diabetes (T1D) and 5% type 2 diabetes (T2D).[3] The offspring of mothers with diabetes
diabetes mellitus 13152 (4.1)PooledPooledPooledPooledPooledPooled350 (162)413 (192)3045 (320)2889 (329)10.05 (4.05)12.1 (4.3)GDM, gestational diabetes mellitus ; HAPO, Hyperglycaemia and Adverse Pregnancy Outcome; LGA, glycated haemoglobin; T1D, type 1 diabetes;
diabetes mellitus 15139 p<0.00001) (see online supplementary figures S5–S6).Subgroup analysesTypes of maternal diabetesGestational diabetes mellitus Ten studies provided body composition data in infants of mothers with and without GDM.[15][21][25][26][28][31]
obesity 23877 meta-analysis.The rising prevalence of GDM in low/middle-income countries is strongly linked to increasing maternal obesity . The HAPO group found that maternal GDM and, to a lesser extent, maternal obesity were independently
obesity 23959 increasing maternal obesity. The HAPO group found that maternal GDM and, to a lesser extent, maternal obesity were independently associated with newborn adiposity with their combination having the greatest impact.[50]
obesity 24882 neonatal adiposity.[53] However, little association was found between maternal glycaemia and offspring obesity at age 2 years in HAPO participants in Belfast (one of 15 study centres),[54] nor have follow-up studies
obesity 25027 in Belfast (one of 15 study centres),[54] nor have follow-up studies shown reduced early childhood obesity following treatment of GDM,[55][56] though intriguingly female offspring had lower fasting glucose concentrations.[55]

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