Ankylosing spondylitis associated with primary aldosteronism in a middle-aged woman.

Existing Reviews

Please note, new claims can take a short while to show up.

No claims yet.

Annotation Summary

Term Occurence Count Dictionary
autoimmune thyroiditis 1 endocrinologydiseases
cortisol 3 endocrinologydiseasesdrugs
dexamethasone 1 endocrinologydiseasesdrugs
hypokalemia 5 endocrinologydiseases
spironolactone 9 endocrinologydiseasesdrugs
thyroglobulin 1 endocrinologydiseasesdrugs
thyroiditis 2 endocrinologydiseases
thyrotoxicosis 2 endocrinologydiseases

Graph of close proximity drug and disease terms (within 200 characters).

Note: If this graph is empty, then there are no terms that meet the proximity constraint.

Review

Having read the paper, please pick a pair of statements from the paper to indicate that a drug and disease are related.

Select Drug Character Offset Drug Term Instance
cortisol 3214 nodular lesion in the left adrenal gland (Fig. 1). A 1 mg dexamethasone suppression test, urinary free cortisol , and diurnal urinary excretion of metanephrines, vanillylmandelic acid, epinephrine, norepinephrine
cortisol 3629 right adrenal vein and 6,390 pg/mL in the left adrenal vein. The dominant and non-dominant aldosterone- cortisol (A/C) ratios were greater than the inferior vena cava A/C ratio. Thus, AVS was considered successful,
cortisol 3754 were greater than the inferior vena cava A/C ratio. Thus, AVS was considered successful, and she had a cortisol -corrected PAC lateralization ratio < 4.0. Therefore, we diagnosed her with bilateral adrenal hyperplasia.
dexamethasone 3169 right adrenal gland and a suspicious small nodular lesion in the left adrenal gland (Fig. 1). A 1 mg dexamethasone suppression test, urinary free cortisol, and diurnal urinary excretion of metanephrines, vanillylmandelic
spironolactone 1334 with primary aldosteronism who developed AS and significantly improved with treatment consisting of spironolactone and a tumor necrosis factor α (TNF-α) inhibitor. Thus, we report a case and review of the literature
spironolactone 3958 hyperplasia. Subsequently, her blood pressure and serum potassium normalized with amlodipine 5 mg and spironolactone 50 mg. At the time of admission to our hospital, she had a normal thyroid stimulating hormone (TSH)
spironolactone 4462 excessive aldosterone and normalized with treatment for primary aldosteronism.During the medical follow-up, spironolactone was tapered to 12.5 mg over 2 years. At that time, she complained of increasing lower back and knee
spironolactone 5958 nonsteroidal anti-inflammatory drugs (NSAIDs) and sulfasalazine with an increasing dose (50 mg) of spironolactone . Refractory to treatment with NSAIDs and sulfasalazine, we decided to start TNF-α inhibitor therapy.
spironolactone 7642 proinflammatory cytokines, such as TNF-α in the presence of an aldosterone-producing adrenal tumor. After spironolactone pretreatment and surgery, the levels of proinflammatory cytokines were reduced and thyroid function
spironolactone 8202 surgery or do not show lateralized aldosterone excess, mineralocorticoid receptor antagonists, such as spironolactone , are a reasonable alternative to adrenalectomy [[1]]. In this patient, lateralized aldosterone secretion
spironolactone 8371 In this patient, lateralized aldosterone secretion was not demonstrated by AVS. Thus, she was given spironolactone and had effectively controlled blood pressure and electrolytes balance. The recent report showed that
spironolactone 8627 increased secretion of TNF-α, transforming growth factor beta, and IL-10 compared to controls, and spironolactone only partially restored these levels [[3]]. Therefore, spironolactone might influence AS treatment.
spironolactone 8697 IL-10 compared to controls, and spironolactone only partially restored these levels [[3]]. Therefore, spironolactone might influence AS treatment. However, that effect was insignificant in our patient, so she also needed
thyroglobulin 4110 our hospital, she had a normal thyroid stimulating hormone (TSH) and elevated free T4. However, serum thyroglobulin , antithyroid peroxidase and TSH receptor antibodies were all negative, and radioactive iodine uptake
Select Disease Character Offset Disease Term Instance
autoimmune thyroiditis 7241 several reports regarding an association between primary aldosteronism and autoimmune diseases such as autoimmune thyroiditis . Tanaka et al. [[4]] described a case of combined primary aldosteronism and Hashimoto’s thyroiditis.
hypokalemia 392 aldosteronism is the main cause of secondary hypertension. This syndrome is characterized by hypertension, hypokalemia , suppressed plasma renin activity (PRA), and increased aldosterone excretion. Both experimental and
hypokalemia 1906 and auscultation of the heart and lungs was normal. Cardiac tests were normal, but thyrotoxicosis and hypokalemia were found. Her serum potassium and blood pressure remained uncorrected despite oral potassium supplementation
hypokalemia 2174 she was referred to our hospital to determine the cause of her refractory arterial hypertension and hypokalemia .On admission, her blood pressure was 164/83 mmHg, pulse rate 70 per minute, body temperature 36°C,
hypokalemia 2469 edema. Laboratory analysis showed hypernatremia (146.3 mEq/L; reference range, 135.0 to 145.0) and hypokalemia (2.7 mEq/L; reference range, 3.5 to 5.5). Based on these findings, primary aldosteronism was highly
hypokalemia 4601 over 2 years. At that time, she complained of increasing lower back and knee pain with recurrence of hypokalemia . She had had intermittent low back pain for the past 10 years. She described chronic inflammatory lower
thyroiditis 7252 reports regarding an association between primary aldosteronism and autoimmune diseases such as autoimmune thyroiditis . Tanaka et al. [[4]] described a case of combined primary aldosteronism and Hashimoto’s thyroiditis.
thyroiditis 7354 thyroiditis. Tanaka et al. [[4]] described a case of combined primary aldosteronism and Hashimoto’s thyroiditis . Krysiak and Okopien [[5]] demonstrated that excessive aldosterone release may lead to the development
thyrotoxicosis 1887 mild cardiomegaly, and auscultation of the heart and lungs was normal. Cardiac tests were normal, but thyrotoxicosis and hypokalemia were found. Her serum potassium and blood pressure remained uncorrected despite oral
thyrotoxicosis 4305 radioactive iodine uptake was only 3% even in a thyrotoxic state. These results may represent a transient thyrotoxicosis due to the inflammatory effect of excessive aldosterone and normalized with treatment for primary aldosteronism.During

You must be authorized to submit a review.