Long Noncoding RNAs in Metabolic Syndrome Related Disorders

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Annotation Summary

Term Occurence Count Dictionary
hyperglycemia 7 endocrinologydiseases
obesity 7 endocrinologydiseases
type 1 diabetes mellitus 1 endocrinologydiseases
type 2 diabetes mellitus 1 endocrinologydiseases
Insulin 1 endocrinologydiseasesdrugs
diabetic retinopathy 4 endocrinologydiseases
metabolic syndrome 3 endocrinologydiseases
diabetes mellitus 6 endocrinologydiseases
hypertriglyceridemia 2 endocrinologydiseases

Graph of close proximity drug and disease terms (within 200 characters).

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Select Drug Character Offset Drug Term Instance
Insulin 30675 LOC283177 expression was found to be directly associated with insulin exocytosis in the islets [[87]]. Insulin is secreted from β-cells in response to glucose, while other nutrients such as free fatty acids and
Select Disease Character Offset Disease Term Instance
diabetes mellitus 26199 four categories, but the vast majority of cases fall into two broad etiopathogenetic groups: type 1 diabetes mellitus (T1DM) or type 2 diabetes mellitus (T2DM) [[77]].Accounting for 5–10% of all cases, T1DM is characterized
diabetes mellitus 26234 majority of cases fall into two broad etiopathogenetic groups: type 1 diabetes mellitus (T1DM) or type 2 diabetes mellitus (T2DM) [[77]].Accounting for 5–10% of all cases, T1DM is characterized by the loss of insulin producing
diabetes mellitus 26542 unrelated to lifestyle. There are genetic variants known to increase the risk of T1DM development. Type 2 diabetes mellitus represents 90–95% of all cases and, unlike T1DM, is strongly associated with patients' lifestyle [[78]].
diabetes mellitus 32634 scientists decided to analyze its function in retinal vasculature and endothelial cell dysfunction in diabetes mellitus [[91]]. lncRNA MALAT1 knockdown in retinas of db/db mice resulted in amelioration of diabetic retinopathy
diabetes mellitus 33642 research group reported that lncRNA MIAT (myocardial infarction-associated transcript) also regulates diabetes mellitus microvascular dysfunction, acting as a competing endogenous RNA [[92]] (Figure 5). Similar to a previous
diabetes mellitus 33946 cells cultured in high glucose medium. As shown by in vivo tests, lncRNA MIAT knockdown ameliorated diabetes mellitus induced retinal microvascular dysfunction. In line with in vivo data, silencing of lncRNA MIAT in endothelial
diabetic retinopathy 31435 of diabetes-related microvascular and macrovascular complications [[16]].One of these complications, diabetic retinopathy , was recently shown to be influenced by lncRNA MALAT1 (metastasis-associated lung adenocarcinoma transcript
diabetic retinopathy 32737 diabetes mellitus [[91]]. lncRNA MALAT1 knockdown in retinas of db/db mice resulted in amelioration of diabetic retinopathy as manifested by reduced apoptosis of retinal cells and pericytes. Additionally, retinal inflammation
diabetic retinopathy 39776 associated with a high risk for development of serious diseases including type 2 diabetes, diabetes-related diabetic retinopathy [[16]], and nonalcoholic fatty liver disease (NAFLD) [[17]], as well as cardiovascular diseases (CVDs)
diabetic retinopathy 40240 lncRAPs) and pathology of metabolic diseases (e.g., type 2 diabetes, HI-LNC25, KCNQ1OT1, LOC283177, diabetic retinopathy , MALAT1, and MIAT) are marked with the red color. In NAFLD, 535 lncRNAs are upregulated and 1,200 are
hyperglycemia 12455 features of the metabolic syndrome: (a) increased waist circumference, (b) insulin resistance, (c) hyperglycemia , (d) hypertension, and (e) hypertriglyceridemia [[15]]. Appearance of these symptoms is associated with
hyperglycemia 25757 β-cells. As a result, blood sugar levels are deregulated and various tissues are exposed to prolonged hyperglycemia that, over time, causes serious damage to many of the body's systems. It should be emphasized that hyperglycemia,
hyperglycemia 25870 that, over time, causes serious damage to many of the body's systems. It should be emphasized that hyperglycemia , a hallmark of diabetes, can cause both acute and long-term complications like cardiovascular disease,
hyperglycemia 27140 properly absorb and metabolize glucose. As a result, β-cells increase insulin production to overcome hyperglycemia , but this compensatory mechanism is transient and generally fails over time [[77]]. Intensified metabolism
hyperglycemia 31238 insulin resistance, is a prime cause of diabetic complications. Among the many tissues affected by hyperglycemia , endothelial cells are very important because they are implicated in pathogenesis of diabetes-related
hyperglycemia 32357 metastasis and recurrence [[90]]. It was shown to be significantly upregulated in a RF/6A cell model of hyperglycemia , in the aqueous tumor samples and in fibrovascular membranes of diabetic patients [[89]].To further
hyperglycemia 39586 The common clinical symptoms of metabolic disorders include abdominal obesity, insulin resistance, hyperglycemia , hypertriglyceridemia, and hypertension [[15]]. Their appearance is associated with a high risk for
hypertriglyceridemia 12496 increased waist circumference, (b) insulin resistance, (c) hyperglycemia, (d) hypertension, and (e) hypertriglyceridemia [[15]]. Appearance of these symptoms is associated with a high risk of serious disease development,
hypertriglyceridemia 39601 clinical symptoms of metabolic disorders include abdominal obesity, insulin resistance, hyperglycemia, hypertriglyceridemia , and hypertension [[15]]. Their appearance is associated with a high risk for development of serious
metabolic syndrome 955 stability. In this review, we summarize data concerning the significance of long noncoding RNAs (lncRNAs) in metabolic syndrome related disorders, focusing on adipose tissue and pancreatic islands.1. IntroductionRecent genome-wide
metabolic syndrome 12372 activity, and genetic susceptibility [[42]]. A great majority of obese individuals present features of the metabolic syndrome : (a) increased waist circumference, (b) insulin resistance, (c) hyperglycemia, (d) hypertension, and
metabolic syndrome 39467 using modified elements from the Servier Medical Art (http://www.servier.com/).Figure 5Development of metabolic syndrome . The common clinical symptoms of metabolic disorders include abdominal obesity, insulin resistance,
obesity 12037 enhancing the inflammatory response [[41]].One disease closely linked to a chronic inflammatory state is obesity . It is characterized by an excessive fat accumulation and enhanced production of proinflammatory cytokines/chemokines
obesity 13449 production of reactive oxygen species and the development of chronic oxidative stress in patients with obesity and metabolic dysfunction [[44], [45]]. In adipose tissue of obese patients is observed severe inflammatory
obesity 17234 Supporting that data, SRA knock-out mice (SRA−/−) are resistant to high fat diet (HFD) induced obesity . After 14 weeks of HFD, SRA−/− mice are characterized by reduced WAT mass and decreased expression
obesity 21343 adult humans. As a result, an understanding of BAT physiology might provide an effective treatment of obesity or other metabolic disorders [[67]]. Identification of the lncRNAs crucial for BAT differentiation and
obesity 26757 lifestyle [[78]]. A number of lifestyle factors are known to be important for development of T2DM including obesity (BMI above 30), lack of physical activity, poor diet, or stress [[79]]. In fact, most patients suffering
obesity 27374 leads to a gradual loss of their endocrine function and finally causes β-cell apoptosis. Similar to obesity , diabetes is a worldwide problem. According to WHO, in 2014, the global prevalence of diabetes was estimated
obesity 39557 5Development of metabolic syndrome. The common clinical symptoms of metabolic disorders include abdominal obesity , insulin resistance, hyperglycemia, hypertriglyceridemia, and hypertension [[15]]. Their appearance
type 1 diabetes mellitus 26192 diabetes into four categories, but the vast majority of cases fall into two broad etiopathogenetic groups: type 1 diabetes mellitus (T1DM) or type 2 diabetes mellitus (T2DM) [[77]].Accounting for 5–10% of all cases, T1DM is characterized
type 2 diabetes mellitus 26227 vast majority of cases fall into two broad etiopathogenetic groups: type 1 diabetes mellitus (T1DM) or type 2 diabetes mellitus (T2DM) [[77]].Accounting for 5–10% of all cases, T1DM is characterized by the loss of insulin producing

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