Fat tissues, the brite and the dark sides

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obesity 294 /2016AbstractFat tissue is well known for its capacity to store energy and its detrimental role in obesity and metaflammation. However, humans possess different types of fat that have different functions in
obesity 1118 Activation of brown and/or brite adipocytes reduces metabolic diseases, at least in murine models of obesity . Thus, brown/brite adipocytes represent the “brite” side of fat and are potential targets for novel
obesity 1270 “brite” side of fat and are potential targets for novel therapeutic approaches for treatment of obesity and obesity-associated diseases.IntroductionObesity and overweight have been conclusively shown to increase
obesity 1282 side of fat and are potential targets for novel therapeutic approaches for treatment of obesity and obesity -associated diseases.IntroductionObesity and overweight have been conclusively shown to increase the
obesity 1791 reported in 2014 that 39 % of adults worldwide were overweight and 13 % were obese. Overweight and obesity are urgent health issues: the numbers have doubled since 1990 and—according to the WHO—more people
obesity 1909 health issues: the numbers have doubled since 1990 and—according to the WHO—more people die of obesity and its consequences than of undernutrition and famine.An important pathophysiological basis of obesity
obesity 2013 obesity and its consequences than of undernutrition and famine.An important pathophysiological basis of obesity and obesity-associated disorders is the increase in adipocyte size due to the uptake/storage of excess
obesity 2025 consequences than of undernutrition and famine.An important pathophysiological basis of obesity and obesity -associated disorders is the increase in adipocyte size due to the uptake/storage of excess energy in
obesity 10967 as “bad” or as the “dark side” of adipose tissue, one might be inclined to overcome or ease obesity via inhibition of adipose tissue expansion [[10], [26]]. It sounds like a reasonable therapeutic approach,
obesity 11820 cardiovascular health, respectively [[9], [18]]. For these reasons, it is clear that other ways to fight obesity are needed.An alternative might be to further the “brite side” of fat by increasing the number of

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