Endocrine manifestations in celiac disease

Existing Reviews

Please note, new claims can take a short while to show up.

No claims yet.

Annotation Summary

Term Occurence Count Dictionary
adrenal insufficiency 3 endocrinologydiseases
autoimmune polyendocrine syndrome 1 endocrinologydiseases
diabetes mellitus 5 endocrinologydiseases
hyperthyroidism 6 endocrinologydiseases
hypoparathyroidism 6 endocrinologydiseases
thyroiditis 5 endocrinologydiseases
type 1 diabetes mellitus 2 endocrinologydiseases
hypogonadism 1 endocrinologydiseases
hypopituitarism 1 endocrinologydiseases
hypothyroidism 8 endocrinologydiseases
myxedema 1 endocrinologydiseases

There are not enough annotations found in this document to create the proximity graph.

Review

Having read the paper, please pick a pair of statements from the paper to indicate that a drug and disease are related.

Select Drug Character Offset Drug Term Instance
Select Disease Character Offset Disease Term Instance
adrenal insufficiency 1673 particularly in children and adolescents. Other endocrine disorders have also been recorded, including adrenal insufficiency and pituitary disease. Usually, only a single endocrine gland is involved in CD, but changes in multiple
adrenal insufficiency 16126 was no apparent temporal sequence in diagnosis of either disorder, it was recommended that cases with adrenal insufficiency be screened for CD, and that CD patients have increased awareness of adrenal insufficiency.Autoimmune
adrenal insufficiency 16217 cases with adrenal insufficiency be screened for CD, and that CD patients have increased awareness of adrenal insufficiency .Autoimmune polyglandular syndromesMore recent reports have emphasized the significance of recognition
autoimmune polyendocrine syndrome 17485 had a beneficial effect on calcium regulation[[78]].In another report, the evolving nature of these autoimmune polyendocrine syndrome s with CD was further emphasized[[79]]. The authors confirmed that APS I most often developed in childhood
diabetes mellitus 1551 particularly endocrine diseases. These include thyroiditis, particularly in adults, and insulin-dependent diabetes mellitus , particularly in children and adolescents. Other endocrine disorders have also been recorded, including
diabetes mellitus 10494 tract.DIABETESEarly reports in CDA number of early reports first described the association between CD and diabetes mellitus , sometimes co-existing with thyroid disease[[6],[33]]. Although most were noted in pediatric-aged patients,
diabetes mellitus 11893 screening for CD in type 1 diabetes, particularly in children[[48]].Pathogenetic linkagesCD and type 1 diabetes mellitus are complex disorders with shared genetic components. The major histocompatibility complex (MHC) is
diabetes mellitus 12514 patients with CD and about 70% of type 1 diabetes[[49]]. There are several HLA and non-HLA loci in type 1 diabetes mellitus shared in CD[[50],[51]]. Non-HLA genes, such as CTLA4, have also been noted in both CD and type 1 diabetes.
diabetes mellitus 13679 in type 1 diabetes is not known, the effects of a gluten-free diet on control of insulin-dependent diabetes mellitus have been explored. Most reported investigations involve studies with animal models. However, in a case
hyperthyroidism 4312 descriptive studies for both children and adults[[3],[4]]. Some early case reports also noted a link with hyperthyroidism [[5]-[7]] while others reported an association with hypothyroidism[[8]-[10]]. Interestingly, the simultaneous
hyperthyroidism 5594 hypothyroidism, but 4 had previously received radio-iodine ablation or thyroidectomy for Grave’s ( hyperthyroidism ) disease. Interestingly, almost half also had dermatitis herpetiformis, an autoimmune dermatological
hyperthyroidism 8327 an altered bowel habit may have impaired absorption, particularly with an increased transit rate in hyperthyroidism . As a result, an apparent failure to respond to a gluten-free diet may be considered. In contrast, hypothyroid
hyperthyroidism 9244 investigators in both children and adults with CD[[24]-[29]]. Far less information is available in Grave’s hyperthyroidism . In 115 consecutive patients with Grave’s hyperthyroidism[[30]], gliadin and tissue transglutaminase
hyperthyroidism 9304 less information is available in Grave’s hyperthyroidism. In 115 consecutive patients with Grave’s hyperthyroidism [[30]], gliadin and tissue transglutaminase antibodies were used to screen for CD. 5 patients were detected,
hyperthyroidism 9615 the basis of these studies, these investigators have suggested that patients with hypothyroidism or hyperthyroidism should have serological screening for CD.Other thyroid disorder in CDFinally, other thyroid disorders
hypogonadism 16760 endocrine disorders, including hypoparathyroidism and usually Addison’s disease, type 1 diabetes, hypogonadism and thyroid disease. Another form usually occurs later in the 3rd or 4th decade (APS, type II), with
hypoparathyroidism 1183 endocrine diseases, such as Addison’s disease are first detected. A number of reports have also recorded hypoparathyroidism or hypopituitarism or ovarian failure in CD and these may be improved with a strict gluten-free diet.Core
hypoparathyroidism 16691 deficiencies, mucocutaneous candidiasis, ectodermal dystrophy and different endocrine disorders, including hypoparathyroidism and usually Addison’s disease, type 1 diabetes, hypogonadism and thyroid disease. Another form usually
hypoparathyroidism 17018 that occur commonly include autoimmune thyroid disease, type 1 diabetes and Addison’s disease while hypoparathyroidism is rare and no mucocutaneous candidiasis develops[[76]]. Although hypoparathyroidism has been rarely
hypoparathyroidism 17103 disease while hypoparathyroidism is rare and no mucocutaneous candidiasis develops[[76]]. Although hypoparathyroidism has been rarely recorded with coincident CD[[77]], the endocrine pattern in adult CD most often fits
hypoparathyroidism 17346 pattern[[76]]. In a very recent report, however, it was noted that in those with concurrent celiac disease and hypoparathyroidism , a gluten-free diet had a beneficial effect on calcium regulation[[78]].In another report, the evolving
hypoparathyroidism 17638 further emphasized[[79]]. The authors confirmed that APS I most often developed in childhood and included hypoparathyroidism , mucocutaneous candidiasis and Addison’s disease. The more common APS II type was often diagnosed
hypopituitarism 1205 Addison’s disease are first detected. A number of reports have also recorded hypoparathyroidism or hypopituitarism or ovarian failure in CD and these may be improved with a strict gluten-free diet.Core tip: Celiac disease
hypothyroidism 685 insulin-dependent or type 1 diabetes, whereas in adults, autoimmune forms of thyroid disease, particularly hypothyroidism , may commonly co-exist. In some with CD, multiple glandular endocrinopathies may also occur and complicate
hypothyroidism 4379 case reports also noted a link with hyperthyroidism[[5]-[7]] while others reported an association with hypothyroidism [[8]-[10]]. Interestingly, the simultaneous occurrence of adult CD and lymphocytic thyroiditis was also
hypothyroidism 4763 measurements of thyroid function suggested that the risk of even clinically overt thyroid disease, especially hypothyroidism , was increased in CD. Some suggested that this may be genetically determined owing to the common detection
hypothyroidism 5494 males, overall average age of CD in this group with thyroid disease, 57.1 years). Of these, 16 had hypothyroidism , but 4 had previously received radio-iodine ablation or thyroidectomy for Grave’s (hyperthyroidism)
hypothyroidism 6270 are similar to a more recent and larger prospective evaluation of 242 celiacs[[17]]. In this study hypothyroidism was present at a similar rate of 12.9%, 3-fold higher than controls of 4.2%. Most interesting were the
hypothyroidism 6526 gluten-free diet for at least 1 year. In these, there was an apparent normalization of subclinical hypothyroidism . In 5 of 91 celiacs with normal thyroid function development of thyroid disease occurred. Others have
hypothyroidism 7905 important clinical implications. A relatively high prevalence of autoimmune thyroid disease, particularly hypothyroidism , in elderly adults may make clinical recognition of CD, at times, difficult. For example, the severity
hypothyroidism 9597 free of symptoms. On the basis of these studies, these investigators have suggested that patients with hypothyroidism or hyperthyroidism should have serological screening for CD.Other thyroid disorder in CDFinally, other
myxedema 8194 circulating thyroid hormone leading to increased time for intestinal transit or fluid retention with myxedema . In addition, some with an altered bowel habit may have impaired absorption, particularly with an increased
thyroiditis 1492 closely linked to a number of extra-intestinal disorders, particularly endocrine diseases. These include thyroiditis , particularly in adults, and insulin-dependent diabetes mellitus, particularly in children and adolescents.
thyroiditis 3697 sites, including endocrine manifestations. Of these, two endocrine disorders are particularly prominent, thyroiditis , especially, but not exclusively, in adults, and insulin-dependent diabetes, particularly, but also
thyroiditis 4476 with hypothyroidism[[8]-[10]]. Interestingly, the simultaneous occurrence of adult CD and lymphocytic thyroiditis was also noted and hypothesized to be more than coincidential[[11]]. In a later report[[12]] from a
thyroiditis 15356 disease). Many occur in the setting of polyendocrine failure that may include Addison’s disease, thyroiditis , ovarian failure and CD[[72]]. In a study of 76 patients (44 females) with Addison’s disease from
thyroiditis 17803 disease. The more common APS II type was often diagnosed if Addison’s disease occurred together with thyroiditis (Schmidt’s syndrome) or type 1 diabetes (Carpenter’s syndrome). Another form, APS 3, may be seen
type 1 diabetes mellitus 11886 urging screening for CD in type 1 diabetes, particularly in children[[48]].Pathogenetic linkagesCD and type 1 diabetes mellitus are complex disorders with shared genetic components. The major histocompatibility complex (MHC) is
type 1 diabetes mellitus 12507 patients with CD and about 70% of type 1 diabetes[[49]]. There are several HLA and non-HLA loci in type 1 diabetes mellitus shared in CD[[50],[51]]. Non-HLA genes, such as CTLA4, have also been noted in both CD and type 1 diabetes.

You must be authorized to submit a review.