The genetic overlap between mood disorders and cardiometabolic diseases: a systematic review of genome wide and candidate gene studies.

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cortisol 3 endocrinologydiseasesdrugs
diabetes mellitus 1 endocrinologydiseases
metabolic syndrome 1 endocrinologydiseases
obesity 12 endocrinologydiseases

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Select Drug Character Offset Drug Term Instance
cortisol 17016 pituitary gland. This in turn stimulates the adrenal gland to produce glucocorticoids (principally cortisol ). Cortisol will then act on several organs including the brain through its receptors.[49] In acute conditions,
cortisol 17154 several organs including the brain through its receptors.[49] In acute conditions, the production of cortisol helps the body to fight pathogens (stress) and alleviate inflammation. However, when stressors are long
cortisol 17300 (stress) and alleviate inflammation. However, when stressors are long lasting (chronic) they can cause cortisol receptor resistance and failure of the HPA-axis negative-feedback mechanism. This increases the duration
Select Disease Character Offset Disease Term Instance
diabetes mellitus 31900 illustrates ingenuity IPA-generated network of the CMMDh genes with coronary artery diseases, hypertension, diabetes mellitus , obesity, depressive disorder and bipolar disorder. The coloured dotted lines highlights CMMDh genes
metabolic syndrome 20334 process. Moreover, AMP activation, for instance during stress, could induce insulin resistance promoting metabolic syndrome , that is, obesity, diabetes and cardiovascular diseases.[55], [56] Hence, it is very likely that inappropriate
obesity 1125 2 diabetes, coronary artery disease, hypertension’ and/or for the risk factors ‘blood pressure, obesity , plasma lipid levels, insulin and glucose related traits’. We then searched the literature for published
obesity 4280 artery diseases,[15] 26–69% in type 2 diabetes,[16], [17] 24–37% in blood pressure,[18] 40–70% in obesity [19] and 58–66% in serum lipids level.[20] Moreover, twin studies have revealed relatively modest genetic
obesity 4911 lipids level ranges from 10 to 31%,[22] and 12% of the genetic component for depression is shared with obesity .[23] Furthermore, gene–environment interactions can contribute to the cardiometabolic and mood disorders
obesity 5998 disorder,[28] bipolar disorder,[29] coronary artery diseases,[30] type 2 diabetes,[31] hypertension,[26] obesity ,[32] plasma lipids level,[33] insulin and glucose traits[31], [34] and blood pressure.[26], [35]Despite
obesity 7995 ‘coronary artery disease’ or ‘hypertension’ and (or) for the risk factors ‘blood pressure’ or ‘ obesity or body mass index (BMI)’ or "plasma lipid levels (high-density lipoprotein, low-density lipoprotein,
obesity 12481 studies for coronary artery disease, 15 studies for hypertension and blood pressure, 26 studies for obesity and BMI, 37 studies for lipids and 20 studies for glucose and insulin traits (Figure 2). As shown in
obesity 14397 genes linked the four most common cardiometabolic disorders (coronary diseases, hypertension, diabetes, obesity ) with BPD and depressive disorder. The CACNB2 and CACNA1D genes have shown network with coronary diseases,
obesity 16139 Genetic variants of the genes for BDNF, CREB1, GNAS and POMC are associated with MDD,[42], [43] BPD,[44] obesity ,[32], [45] blood pressure and hypertension.[35], [46] The genes belong to the group of stress responsive
obesity 20363 for instance during stress, could induce insulin resistance promoting metabolic syndrome, that is, obesity , diabetes and cardiovascular diseases.[55], [56] Hence, it is very likely that inappropriate activity
obesity 31919 IPA-generated network of the CMMDh genes with coronary artery diseases, hypertension, diabetes mellitus, obesity , depressive disorder and bipolar disorder. The coloured dotted lines highlights CMMDh genes that were
obesity 37219 body size and body fat accumulation. Studies in mice and humans indicate its role in body mass index, obesity risk, and type 2 diabetes.Obesity rs7185735-G/A[32], [111] Type 2 diabetes rs9936385-C/T[95] HDL or
obesity 37548 of the FTO gene were involved in the mechanism underlying the association between mood disorders and obesity .[113]POMCMaintain the body"s energy balance and control sodium in the bodyObesity (BMI) rs713586-C/T[45] rs1561288-T/C[114] rs10182181-G/A[111]Genetic

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