Why Is Apolipoprotein CIII Emerging as a Novel Therapeutic Target to Reduce the Burden of Cardiovascular Disease?

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Term Occurence Count Dictionary
metabolic syndrome 1 endocrinologydiseases
obesity 1 endocrinologydiseases
hypertriglyceridemia 6 endocrinologydiseases

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hypertriglyceridemia 2202 including modulation of endothelial function and inflammation [[], []].The connection of apoC-III with hypertriglyceridemia and CVD risk has been confirmed in extensive animal and humans studies [[], []]. Furthermore, given
hypertriglyceridemia 4611 increased in insulin-resistant states such as obesity, the metabolic syndrome, type 2 diabetes, and hypertriglyceridemia [[], [], []].ApoC-III is a small protein (79 amino acid residues) that contains two amphipathic helices
hypertriglyceridemia 6207 vivo with apoC-III transgenic mice have demonstrated that overexpression of apoC-III induces marked hypertriglyceridemia due to accumulation of remnant particles with increased apoC-III and decreased apoE content compared
hypertriglyceridemia 15262 meta-analysis of three main apoC-III polymorphisms (SstI, T-455C, and C-482T) known to associate with hypertriglyceridemia in mice [[]] reported that two polymorphisms (SstI and T-455C) significantly increased the susceptibility
hypertriglyceridemia 19027 VLDL triglyceride levels in patients with familial chylomicron syndrome and with variable types of hypertriglyceridemia [[], []••, []••]. The data also demonstrated that the lowering of serum apoC-III levels and
hypertriglyceridemia 19843 APPROACH study and COMPASS) and will clarify the efficacy of the drug intervention in subjects with severe hypertriglyceridemia defined as triglyceride levels above 5.7 mmol/l (>500 mg/dl) [[]].Gaps in Knowledge of ApoC-IIIImportant
metabolic syndrome 4570 explain why apoC-III concentrations are increased in insulin-resistant states such as obesity, the metabolic syndrome , type 2 diabetes, and hypertriglyceridemia [[], [], []].ApoC-III is a small protein (79 amino acid residues)
obesity 4557 mechanism may explain why apoC-III concentrations are increased in insulin-resistant states such as obesity , the metabolic syndrome, type 2 diabetes, and hypertriglyceridemia [[], [], []].ApoC-III is a small

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