Effects of Bariatric Surgery on Renal Function in Obese Patients: A Systematic Review and Meta Analysis.

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Term Occurence Count Dictionary
diabetes mellitus 3 endocrinologydiseases
metabolic syndrome 1 endocrinologydiseases
obesity 12 endocrinologydiseases
type 2 diabetes mellitus 1 endocrinologydiseases

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Select Drug Character Offset Drug Term Instance
Select Disease Character Offset Disease Term Instance
diabetes mellitus 3015 population-based studies including more than 19 million participants [[1]]. Also, obesity is a strong trigger of diabetes mellitus (DM), dyslipidemia, hypertension and metabolic syndrome which are strong risk factors for the development
diabetes mellitus 18051 stages III; DN3: Diabetic Nephropathy stages III; DN4: Diabetic Nephropathy stages IV; T2DM: type 2 diabetes mellitus , AGB: Adjustable Gastric Band; SG: Sleeve Gastrectomy; BPD: Biliopancreatic Diversion; RYGB: Roux-en-Y
diabetes mellitus 29895 risk-stratification for both CKD and cardiovascular disease [[66], [68], [69]]. Albuminuria comes from diabetes mellitus (DM), thus, remission of diabetes may affect the improvement of renal function after bariatric surgery.
metabolic syndrome 3070 [[1]]. Also, obesity is a strong trigger of diabetes mellitus (DM), dyslipidemia, hypertension and metabolic syndrome which are strong risk factors for the development and progression of chronic kidney disease (CKD)[[2],
obesity 2793 Non-Communicable Diseases Risk Factor Collaboration revealed that between 1975 and 2014 the prevalence of obesity increased from 3.2% to 10.8% in men and from 6.4% to 14.9% in women in their pooled analysis of 1698
obesity 2984 analysis of 1698 population-based studies including more than 19 million participants [[1]]. Also, obesity is a strong trigger of diabetes mellitus (DM), dyslipidemia, hypertension and metabolic syndrome which
obesity 3631 improved metabolic disorder on renal diseases after bariatric surgery have been poorly evaluated.Extreme obesity is responsible for glomerulosclerosis [[7]]. Renal diseases in the setting of obesity often manifest
obesity 3717 evaluated.Extreme obesity is responsible for glomerulosclerosis [[7]]. Renal diseases in the setting of obesity often manifest albuminuria, proteinuria, glomerular hyperfiltration and decreased glomerular filtration
obesity 7857 and mGFR values adjusted for BSA lead to a systematic underestimation of GFR in patients with severe obesity [[17]]. Thus CrCl, eGFR with and without BSA are all clearly unreliable. In our review, we draw conclusions
obesity 25331 chronic kidney disease [[54]–[56]]. Several studies showed that glomerular hyperfiltration caused by obesity reflected loss of renal functional reserve and contributed to the development and progressive of CKD
obesity 25542 [[57], [58]]. Firstly, glomerulomegaly and focal glomerulosclerosis have been closely associated with obesity in order to meet increased metabolic demands in morbidly obese patients. These disorders are characterized
obesity 26446 and mGFR values adjusted for BSA lead to a systematic underestimation of GFR in patients with severe obesity [[17]], thus they are clearly unreliable with adjusted for BSA. In our review, we draw conclusions from
obesity 26956 hyperfiltration could translate into long-term renal benefits remains to be seen.The association between obesity and CKD may be mediated through multiple biologic mechanisms. Excess adipose tissue can lead to the
obesity 27262 hyperfiltration, and increased sodium absorption in the kidneys, resulting in a feedback loop where obesity -induced declines in kidney function lead to the development of hypertension, which results in further
obesity 27430 of hypertension, which results in further damage to the kidneys [[59], [60]]. Pathways leading from obesity to diabetes have also been identified, including the development of insulin resistance through the disruption
obesity 30515 heterogeneity in our meta-analysis was mainly attributed to differences in population, duration of obesity , study design, follow-up, sample size or co-morbidities.Our review has some strengths and limitations.
type 2 diabetes mellitus 18044 disease stages III; DN3: Diabetic Nephropathy stages III; DN4: Diabetic Nephropathy stages IV; T2DM: type 2 diabetes mellitus , AGB: Adjustable Gastric Band; SG: Sleeve Gastrectomy; BPD: Biliopancreatic Diversion; RYGB: Roux-en-Y

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