Influence of Bisphenol A on Type 2 Diabetes Mellitus

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Term Occurence Count Dictionary
17β-estradiol 2 endocrinologydiseasesdrugs
Insulin 2 endocrinologydiseasesdrugs
glucose intolerance 2 endocrinologydiseases
hyperglycemia 1 endocrinologydiseases
hyperinsulinemia 3 endocrinologydiseases
obesity 1 endocrinologydiseases
diabetes mellitus 4 endocrinologydiseases
hyperandrogenism 1 endocrinologydiseases
type 2 diabetes mellitus 3 endocrinologydiseases

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Select Drug Character Offset Drug Term Instance
17β-estradiol 21958 BPA binding affinity to ER is extremely weak—1000 to 10,000 times lower than the ER natural ligand 17β-estradiol —thus suggesting that BPA might have additional mechanisms of action, which are independent of ER [[15],[59]].
17β-estradiol 24975 the rapid enhance of the frequency of glucose-induced Ca2+ ions oscillations, mimicking the effect of 17β-estradiol through a non-classical membrane ER (ncmER) involved in the non-genomic actions of estrogens and xenoestrogens,
Insulin 13076 by affecting adipocyte metabolic functions, with the consequent development of insulin resistance. Insulin resistance is a pathological state characterized by an impairment of insulin action in different compartments,
Insulin 28219 activation of the cGMP-dependent protein kinase (PKG) that blocks ion channels [[70]].4.3. BPA Action on Insulin Sensitivity in Peripheral Tissues: Human, Animal and Cell StudiesThe effect of BPA on insulin sensitivity
Select Disease Character Offset Disease Term Instance
diabetes mellitus 1445 BPA exposure, evaluated by the measurement of urinary BPA levels, and the risk of developing type 2 diabetes mellitus . Clinical studies on humans and preclinical studies on in vivo, ex vivo, and in vitro models indicate
diabetes mellitus 1633 vivo, and in vitro models indicate that BPA, mostly at low doses, may have a role in increasing type 2 diabetes mellitus developmental risk, directly acting on pancreatic cells, in which BPA induces the impairment of insulin
diabetes mellitus 2027 current review summarizes the available evidences regarding the association between BPA and type 2 diabetes mellitus , focusing on both clinical and preclinical studies.1. IntroductionType 2 diabetes mellitus (T2DM) is
diabetes mellitus 2118 and type 2 diabetes mellitus, focusing on both clinical and preclinical studies.1. IntroductionType 2 diabetes mellitus (T2DM) is becoming a major public health problem, approaching epidemic proportions [[1]]. According
glucose intolerance 20211 of BPA-treated offspring compared with the controls, contributing to the subsequent pathogenesis of glucose intolerance [[49]].In summary, preclinical animal studies demonstrate that low levels of BPA exposure during pregnancy
glucose intolerance 29779 beta (GSK3β) phosphorylation, which contributes to the development of an insulin resistance state and glucose intolerance [[64],[71],[73]]. In particular, male albino rats treated for 30 days with 20 mg/kg/day and 200 mg/kg/day
hyperandrogenism 7952 adults), have shown higher serum BPA levels when exposed to equal levels of BPA. Moreover, women with hyperandrogenism showed higher serum BPA levels than normal women [[28]]. Furthermore, gender differences in BPA actions
hyperglycemia 2682 citizens with T2DM will rise to 5.37 million by 2030 [[2]]. T2DM is a metabolic disease characterized by hyperglycemia , resulting from a progressive loss of insulin secretion on the background of insulin resistance [[3]].
hyperinsulinemia 17577 μg/kg/day), induced postnatal body weight gain, impairment of glucose tolerance and insulin resistance with hyperinsulinemia , an increase in adipocyte number and volume with consequent increase in abdominal fat, and an increase
hyperinsulinemia 18283 produce offspring that, although fed with a normal diet, can develop insulin resistance with compensatory hyperinsulinemia and impairment of glucose tolerance in adult age, suggesting that BPA can mimic the effects of a high-fat
hyperinsulinemia 28731 the dose of 10 or 100 μg/kg for a chronic treatment of 4, 8, and 15 days and for 12 weeks developed hyperinsulinemia , insulin resistance, and an impairment of glucose tolerance [[52],[64],[71],[72],[73]]. Moreover, BPA
obesity 11635 T2DM risk seems to be influenced by genetic predisposition, such as single nucleotide polymorphysms in obesity -associated genes, which makes the subjects more sensitive to the deleterious effect of BPA [[11]]. It
type 2 diabetes mellitus 1438 between BPA exposure, evaluated by the measurement of urinary BPA levels, and the risk of developing type 2 diabetes mellitus . Clinical studies on humans and preclinical studies on in vivo, ex vivo, and in vitro models indicate
type 2 diabetes mellitus 1626 ex vivo, and in vitro models indicate that BPA, mostly at low doses, may have a role in increasing type 2 diabetes mellitus developmental risk, directly acting on pancreatic cells, in which BPA induces the impairment of insulin
type 2 diabetes mellitus 2020 state. The current review summarizes the available evidences regarding the association between BPA and type 2 diabetes mellitus , focusing on both clinical and preclinical studies.1. IntroductionType 2 diabetes mellitus (T2DM) is

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