The Molecular and Cellular Effect of Homocysteine Metabolism Imbalance on Human Health

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Term Occurence Count Dictionary
cystinuria 6 endocrinologydiseases
homocystinuria 6 endocrinologydiseases
hyperhomocysteinemia 4 endocrinologydiseases
osteoporosis 1 endocrinologydiseases
vitamin B12 deficiency 1 endocrinologydiseases

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cystinuria 4206 widely accepted that increased level of Hcy in plasma is linked with cardiovascular diseases or homo cystinuria . Approximately 85% of all SAM-dependent transmethylations are due to these two MTs [[3]]. Hepatic PEMT
cystinuria 9126 physiological processes [[11]]. The impairment of transsulfuration processes is associated with homo cystinuria , autism, cirrhosis, immune dysfunction or pancreatitis [[12],[13],[14],[15]].Hcy is formed in all tissues.
cystinuria 11606 μM), intermediate (31–100 μM), and severe (higher than 100 μM) [[21]]. Severe hHcy occurs in homo cystinuria , an innate metabolic disorder characterized by a deficiency of CBS enzyme activity. Affected patients
cystinuria 24561 elevated levels of Hcy in the urine. They revealed a new disorder of Met metabolism referred to as homo cystinuria . In 1969, McCully published a study showing on the vascular pathologies in patients with homocystinuria.
cystinuria 24665 homocystinuria. In 1969, McCully published a study showing on the vascular pathologies in patients with homo cystinuria . It was the first time that elevated Hcy level was linked to premature vascular disease [[60]]. By the
cystinuria 31361 be considered as a coronary heart disease equivalent [[88]]. Patients with severe hHcy occur in homo cystinuria , an inherited metabolic disorder characterized by a deficiency of CBS enzyme activity [[89]]. Affected
homocystinuria 4202 is widely accepted that increased level of Hcy in plasma is linked with cardiovascular diseases or homocystinuria . Approximately 85% of all SAM-dependent transmethylations are due to these two MTs [[3]]. Hepatic PEMT
homocystinuria 9122 of physiological processes [[11]]. The impairment of transsulfuration processes is associated with homocystinuria , autism, cirrhosis, immune dysfunction or pancreatitis [[12],[13],[14],[15]].Hcy is formed in all tissues.
homocystinuria 11602 (16–30 μM), intermediate (31–100 μM), and severe (higher than 100 μM) [[21]]. Severe hHcy occurs in homocystinuria , an innate metabolic disorder characterized by a deficiency of CBS enzyme activity. Affected patients
homocystinuria 24557 elevated levels of Hcy in the urine. They revealed a new disorder of Met metabolism referred to as homocystinuria . In 1969, McCully published a study showing on the vascular pathologies in patients with homocystinuria.
homocystinuria 24661 homocystinuria. In 1969, McCully published a study showing on the vascular pathologies in patients with homocystinuria . It was the first time that elevated Hcy level was linked to premature vascular disease [[60]]. By the
homocystinuria 31357 can be considered as a coronary heart disease equivalent [[88]]. Patients with severe hHcy occur in homocystinuria , an inherited metabolic disorder characterized by a deficiency of CBS enzyme activity [[89]]. Affected
hyperhomocysteinemia 1455 non-proteinogenic amino acid derived in methionine metabolism. The increased level of Hcy in plasma, hyperhomocysteinemia , is considered to be an independent risk factor for cardio and cerebrovascular diseases. However, it
hyperhomocysteinemia 1853 review represents the current understanding of molecular mechanism of Hcy metabolism and its link to hyperhomocysteinemia -related pathologies in humans. The aberrant Hcy metabolism could lead to the redox imbalance and oxidative
hyperhomocysteinemia 6057 due to reduced synthesis of SAM is among the central mechanisms that explain the negative effect of hyperhomocysteinemia related to vascular diseases and neurodegenerative disorders where synthesis in neurotransmitters and
hyperhomocysteinemia 11381 conditions, plasma Hcy concentrations do not exceed 15 μM [[20]]. Elevation of plasma Hcy is manifested as hyperhomocysteinemia (hHcy). Several types of hHcy are classified in relation to the tHcy concentration: moderate (16–30
osteoporosis 25205 strong correlation between elevated Hcy levels and neurological disorders, chronic kidney disease, osteoporosis , gastrointestinal disorders, cancer and congenital defects development [[44],[61],[62],[63],[64]].4.1.
vitamin B12 deficiency 10686 stroke progression, screening for inborn errors of Met metabolism, and as a supplementary test for vitamin B12 deficiency . The methods used to determine Hcy level in different biological samples can be classified into chromatographic

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