Diabetes in HFE Hemochromatosis.

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Annotation Summary

Term Occurence Count Dictionary
hyperglycemia 1 endocrinologydiseases
metabolic syndrome 2 endocrinologydiseases
obesity 3 endocrinologydiseases
Insulin 2 endocrinologydiseasesdrugs
diabetes mellitus 1 endocrinologydiseases
glucose intolerance 1 endocrinologydiseases

Graph of close proximity drug and disease terms (within 200 characters).

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Select Drug Character Offset Drug Term Instance
Insulin 10223 hepcidin and may contribute to iron homeostasis and blood glucose regulation [[41]].5.4. Decreased Insulin Secretion in HFE HemochromatosisIn an early study, some patients with hemochromatosis had subnormal
Insulin 10744 p.C282Y homozygotes) and mean SF 1501 ± 287 (standard deviation) ng/mL [[1]].5.5. Iron, Islet Cells, and Insulin Secretion in Hfe−/− MiceIron metabolism characteristics of Hfe knockout (Hfe−/−) mice are inherited
Select Disease Character Offset Disease Term Instance
diabetes mellitus 3915 [[6]]. Clinicians in Europe and derivative countries reported the association of hemochromatosis and diabetes mellitus in whites with increasing frequency in the remaining 19th C [[7]]. Diabetes, a sine qua non of most
glucose intolerance 17379 unselected for hemochromatosis diagnoses. In a longitudinal study, SF levels were positively associated with glucose intolerance and IR [[86]]. In overall HEIRS Study analyses of observations of 97,470 participants, SF levels were
hyperglycemia 22092 populations unselected for hemochromatosis diagnoses [[117]]. Subclinical inflammation is associated with hyperglycemia and IR in type 2 diabetes unassociated with hemochromatosis [[118]]. Single-nucleotide polymorphisms
metabolic syndrome 937 secretion, cirrhosis, diabetes in first-degree relatives, increased body mass index, insulin resistance, and metabolic syndrome . In p.C282Y homozygotes, serum ferritin, usually elevated at hemochromatosis diagnosis, largely reflects
metabolic syndrome 22550 in persons with HFE hemochromatosis also increases diabetes risk [[10], [51], [74], [120]]. IR and metabolic syndrome (MetS) are common in patients with hemochromatosis [[42], [121]–[123]]. In non-Hispanic white adults
obesity 21647 factors. Common inflammatory disorders in persons with diabetes, with or without hemochromatosis, include obesity , arthropathy, atherosclerosis, dyslipidemia, microvascular disease, and fatty liver. In persons with
obesity 24506 hemochromatosis are typical of those that occur in patients without hemochromatosis. These include obesity ; fat atrophy; proteinuria/albuminuria; retinopathy; peripheral neuropathy; and coronary artery and peripheral
obesity 28663 Modifiable risks for patients with elevated CRP include suboptimal physical activity (men) and central obesity and lack of statin use (women) [[116]]. Some patients with diabetes would benefit from reduced consumption

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