How significant is the association between metabolic syndrome and prevalence of colorectal neoplasia?

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Term Occurence Count Dictionary
metabolic syndrome 4 endocrinologydiseases
obesity 14 endocrinologydiseases
type 2 diabetes mellitus 1 endocrinologydiseases
Insulin 1 endocrinologydiseasesdrugs
diabetes mellitus 6 endocrinologydiseases
hyperglycemia 3 endocrinologydiseases
hyperinsulinemia 2 endocrinologydiseases
hypertriglyceridemia 1 endocrinologydiseases

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Having read the paper, please pick a pair of statements from the paper to indicate that a drug and disease are related.

Select Drug Character Offset Drug Term Instance
Insulin 10660 CRC[[28]]. This association is based on the hypothesis that hyperinsulinemia promotes colon carcinogenesis. Insulin resistance leads to a compensatory increase in insulin secretion, and this hyperinsulinemia may lead
Select Disease Character Offset Disease Term Instance
diabetes mellitus 1450 same - obesity, impaired glucose tolerance, dyslipidemia, hypertension, cardiovascular diseases and diabetes mellitus type 2. Therefore, the key issue in the near future is the development of a simple scoring system, easy
diabetes mellitus 2825 risk factors that often occur together and lead to the development of cardiovascular disease, type 2 diabetes mellitus and certain types of cancer, especially tumors of the gastrointestinal and genitourinary tracts[[3],[4]].
diabetes mellitus 11741 dysglycemia, a condition including states of impaired fasting glucose and impaired glucose tolerance, or overt diabetes mellitus type 2[[27]]. Another meta-analysis[[33]] of 29 eligible studies confirmed these estimates indicating
diabetes mellitus 23081 performed).Based on the collected data, the individuals were divided into a target group (patients with diabetes mellitus type 2 and/or cardiovascular risk) and a control group. The diagnosis of diabetes mellitus type 2 was
diabetes mellitus 23172 (patients with diabetes mellitus type 2 and/or cardiovascular risk) and a control group. The diagnosis of diabetes mellitus type 2 was assessed by glucose and glycated hemoglobin serum levels and confirmed by the oral glucose
diabetes mellitus 26950 models were adjusted for age, sex and previous FIT+ (fecal immunochemical test positivity). DM2: Type 2 diabetes mellitus ; SCORE: Systematic COronary Risk Evaluation.As a conclusion of these preliminary results, individualized
hyperglycemia 2995 the gastrointestinal and genitourinary tracts[[3],[4]]. These risk factors include abdominal obesity, hyperglycemia , elevated blood pressure, elevated triglycerides and a low high-density lipoprotein (HDL) serum fraction
hyperglycemia 16773 evidence to support the claim that subjects with MS are at increased risk of developing CRC. Obesity and hyperglycemia are key components of MS and CRC. According to these results, it appears that MS is also associated
hyperglycemia 27290 increasing prevalence worldwide. It has been shown that the strongest risk factors are central obesity and hyperglycemia in relation to CRC. Furthermore, cardiovascular risk is directly associated with the risk of colorectal
hyperinsulinemia 10612 be a risk factor for the development of CRC[[28]]. This association is based on the hypothesis that hyperinsulinemia promotes colon carcinogenesis. Insulin resistance leads to a compensatory increase in insulin secretion,
hyperinsulinemia 10743 carcinogenesis. Insulin resistance leads to a compensatory increase in insulin secretion, and this hyperinsulinemia may lead to increased levels of free insulin-like growth factor-1, an antiapoptotic and mitogenic factor
hypertriglyceridemia 12004 (RR = 1.29 for men and 1.34 for women).DYSLIPIDEMIA AND COLORECTAL NEOPLASIAThe mechanism by which hypertriglyceridemia promotes CRC is unknown. One of the hypotheses cites the effect of secondary bile salts in the colon.
metabolic syndrome 83 Title: World Journal of GastroenterologyHow significant is the association between metabolic syndrome and prevalence of colorectal neoplasia?Stepan SuchanekTomas GregaOndrej NgoGabriela VojtechovaOndrej
metabolic syndrome 400 ZavoralPublication date (ppub): 9/2016Publication date (epub): 9/2016AbstractThe incidence and prevalence of metabolic syndrome (MS) and colorectal cancer (CRC) has been rising in developed countries. The association between these
metabolic syndrome 2232 preliminary results of a Czech multi-center prospective study investigating the relationship between metabolic syndrome and colorectal neoplasia are provided.INTRODUCTIONThe incidence and prevalence of metabolic syndrome
metabolic syndrome 2333 metabolic syndrome and colorectal neoplasia are provided.INTRODUCTIONThe incidence and prevalence of metabolic syndrome (MS) is rising in developed countries. The prevalence of MS based on National Cholesterol Education
obesity 1357 should be changed. Metabolic risk factors for the development of adenomas and cancers are the same - obesity , impaired glucose tolerance, dyslipidemia, hypertension, cardiovascular diseases and diabetes mellitus
obesity 2986 tumors of the gastrointestinal and genitourinary tracts[[3],[4]]. These risk factors include abdominal obesity , hyperglycemia, elevated blood pressure, elevated triglycerides and a low high-density lipoprotein (HDL)
obesity 6926 C-reactive protein[[15]]. This chronic inflammatory process can result in a positive association between obesity and CRC risk. Additionally, a large number of newly discovered adipokines, such as leptin, adiponectin
obesity 7095 discovered adipokines, such as leptin, adiponectin and resistin, are considered to be potential mediators of obesity in cancer development[[16]].The most common definition of obesity is a body mass index (BMI) of 30 kg/m2
obesity 7161 considered to be potential mediators of obesity in cancer development[[16]].The most common definition of obesity is a body mass index (BMI) of 30 kg/m2 or greater. A large number of studies have reported an association
obesity 7866 population[[19]]. The results of a large meta-analysis, including 70000 CRC cases, also indicate that obesity is directly and independently associated with CRC[[20]]. Individuals with a BMI ≥ 30 kg/m2 have a
obesity 8226 developing CRC increased by 7%. Similarly, a 2-cm increase in waist circumference, a measure of central obesity , was associated with a 4% greater risk of CRC. These findings are similar to the results of another
obesity 9084 than in women (RR = 1.12, 95%CI: 1.06-1.16).The reason for a sex difference in the association between obesity and CRC may be partly explained by different hormonal levels (especially estrogen) in women. The Women's
obesity 9579 be the differential distribution of adipose tissue. Several studies have demonstrated that central obesity is an independent risk factor of colorectal neoplasia and represents a higher risk factor for CRC than
obesity 9924 a waist circumference of 102 cm in men and 88 cm in women as being the cut-off points for abdominal obesity that is associated with an increased risk of morbidity. Findings from the European Prospective Investigation
obesity 10102 the European Prospective Investigation into Cancer and Nutrition indicated that central (abdominal) obesity is an equally strong risk factor for CRC in both genders, whereas body weight and BMI are associated
obesity 19352 assessed the utility of the APCS system and the presence of MS components and found that in cases with obesity , the colorectal tumor detection rate significantly increased (59.5% vs 19.2% for the MR/HR group without
obesity 19465 colorectal tumor detection rate significantly increased (59.5% vs 19.2% for the MR/HR group without obesity , P < 0.01). Utilization of the APCS scoring system in the Western population was examined in an Australian
obesity 27278 shows increasing prevalence worldwide. It has been shown that the strongest risk factors are central obesity and hyperglycemia in relation to CRC. Furthermore, cardiovascular risk is directly associated with the
type 2 diabetes mellitus 2818 combination of risk factors that often occur together and lead to the development of cardiovascular disease, type 2 diabetes mellitus and certain types of cancer, especially tumors of the gastrointestinal and genitourinary tracts[[3],[4]].

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