Clinical utility of lanreotide Autogel® in gastroenteropancreatic neuroendocrine tumors

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Term Occurence Count Dictionary
acromegaly 3 endocrinologydiseases
diabetes mellitus 1 endocrinologydiseases
hypercalcemia 1 endocrinologydiseases
neuroendocrine tumor 2 endocrinologydiseases
hypokalemia 1 endocrinologydiseases
niacin 1 endocrinologydiseasesdrugs
pellagra 1 endocrinologydiseases
thyroid carcinoma 1 endocrinologydiseases
carcinoid 8 endocrinologydiseases
glucose intolerance 1 endocrinologydiseases
hyperglycemia 2 endocrinologydiseases
hypoglycemia 2 endocrinologydiseases

Graph of close proximity drug and disease terms (within 200 characters).

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Select Drug Character Offset Drug Term Instance
niacin 28118 sweating, telangiectasias, cardiac fibrosis, and cutaneous pellagra-like manifestations due to lack of niacin .[39] These can be very distressing for patients and have a negative impact on their quality of life.
Select Disease Character Offset Disease Term Instance
acromegaly 2378 the development of additional SSTR ligands offered a great opportunity for the medical treatment of acromegaly and neuroendocrine neoplasms (NENs).With an annual incidence of 5 cases/100,000 in the USA,[1] NENs
acromegaly 7753 (“first-generation” SSAs) have been quickly considered first-line medical therapeutic options for the treatment of acromegaly and for the control of hormonal symptoms in patients with NENs.[11] OCT and LAN show high-affinity binding
acromegaly 21762 of LAN Autogel in GEP-NENsLAN Autogel has been approved for the long-term treatment of patients with acromegaly and for the treatment of GEP-NENs in order to delay disease progression in patients with G1 or a subset
carcinoid 1769 tumor-related symptoms in the majority of patients affected by GEP tumors, especially in patients affected by carcinoid syndrome, improving considerably patients’ quality of life.IntroductionThe discovery of somatotropin-release
carcinoid 13220 and autoradiography reveal that SSTR proteins are highly expressed in gastrinomas, insulinomas, and carcinoid tumors, and their metastases. The majority of the tumors express SSTR 2, followed by SSTR 1, SSTR 5,
carcinoid 13689 GEP-NENs than well-differentiated tumors. The largest expression of SSTR 2 on pancreatic endocrine or carcinoid tumors is the reason for the successful clinical application of OCT and LAN in controlling symptoms
carcinoid 16341 determination in 24-hour urine collection has a sensitivity of over 90% and a specificity of 90% for advanced carcinoid syndrome (CS).[42] Various blood serotonin assays have been proposed, but their actual accuracy has
carcinoid 29244 and patient perception of LAN injection.[56],[57]Although in the majority of patients with metastatic carcinoid s and pancreatic endocrine tumors treatment with SSAs induces a rapid improvement of clinical symptomatology
carcinoid 34064 colonGEP-NEN classification according to grade of differentiation[38],aWell-differentiated tumors (“ carcinoid ”)Mild or no atypia, restricted to the mucosa or submucosa, absence of angioinvasion, tumor size <1
carcinoid 34278 and proliferation rate <2 mitoses/10 HPFs or Ki-67 <2%Well-differentiated carcinomas (“malignant carcinoid ”)Malignant endocrine tumor cells, moderate atypia, deep invasion of the gut wall, often metastases
carcinoid 41947 those showing Ki-67 ≥5%Abbreviations: 5-HIAA, 5-hydroxyindoleacetic acid; CgA, chromogranin A; CS, carcinoid syndrome; GEP, gastroenteropancreatic; LAN, lanreotide; NENs, neuroendocrine neoplasms; OCT, octreotide;
diabetes mellitus 17303 concentrations for the diagnosis of glucagonoma, associated with a characteristic clinical syndrome ( diabetes mellitus and cutaneous manifestations, such as migratory necrolytic erythema, nail dystrophies, and stomatitis),
glucose intolerance 17636 characterized by watery diarrhea, hypokalemia, achlorhydria, weight loss, metabolic acidosis, hypercalcemia, glucose intolerance , and flushing.Different from the hypersecreting NENs, which can present with specific endocrine syndromes,
hypercalcemia 17621 syndrome, characterized by watery diarrhea, hypokalemia, achlorhydria, weight loss, metabolic acidosis, hypercalcemia , glucose intolerance, and flushing.Different from the hypersecreting NENs, which can present with specific
hyperglycemia 20601 secretion of insulin and glucagon. Hence, patients treated with LAN may experience hypoglycemia or hyperglycemia . For this reason, glucose levels should be monitored during treatment with LAN, especially in diabetic
hyperglycemia 25576 (~90%), but half the patients treated with LAN Autogel experienced drug-related adverse events (diarrhea, hyperglycemia , or cholelithiasis).The decrease of CgA levels during treatment with LAN Autogel from baseline was associated
hypoglycemia 17067 gastric pH <2 are virtually diagnostic of Zollinger–Ellison syndrome. The occurrence of symptomatic hypoglycemia with non-suppressed endogenous insulin levels is suspicious for insulinoma. Other specific markers include
hypoglycemia 20585 SSAs, inhibits the secretion of insulin and glucagon. Hence, patients treated with LAN may experience hypoglycemia or hyperglycemia. For this reason, glucose levels should be monitored during treatment with LAN, especially
hypokalemia 17561 VIP-secreting tumors which cause the Verner–Morrison syndrome, characterized by watery diarrhea, hypokalemia , achlorhydria, weight loss, metabolic acidosis, hypercalcemia, glucose intolerance, and flushing.Different
neuroendocrine tumor 110 Drug Design, Development and TherapyClinical utility of lanreotide Autogel® in gastroenteropancreatic neuroendocrine tumor sRosa Maria ParagliolaAlessandro PreteGiampaolo PapiFrancesco TorinoAndrea CorselloAlfredo PontecorviSalvatore
neuroendocrine tumor 35644 the term “neuroendocrine neoplasm” to indicate low- to high-grade lesions. However, the term “ neuroendocrine tumor ” is still widely used. The term “neuroendocrine carcinoma” indicates high-grade lesions.cKi-67
pellagra 28074 frequent events are lacrimation, profuse sweating, telangiectasias, cardiac fibrosis, and cutaneous pellagra -like manifestations due to lack of niacin.[39] These can be very distressing for patients and have a
thyroid carcinoma 12063 gastrointestinal and bronchopulmonary systems, as well as of pituitary tumors, medulloblastomas, medullary thyroid carcinoma s, and adenocarcinomas of the breast, ovary, and colon.[7],[28] On the other hand, poorly differentiated

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