A review of recent evidence relating to sugars, insulin resistance and diabetes.

Existing Reviews

Please note, new claims can take a short while to show up.

No claims yet.

Annotation Summary

Term Occurence Count Dictionary
diabetes mellitus 2 endocrinologydiseases
metabolic syndrome 2 endocrinologydiseases
obesity 8 endocrinologydiseases
type 2 diabetes mellitus 2 endocrinologydiseases
Insulin 1 endocrinologydiseasesdrugs

Graph of close proximity drug and disease terms (within 200 characters).

Note: If this graph is empty, then there are no terms that meet the proximity constraint.

Review

Having read the paper, please pick a pair of statements from the paper to indicate that a drug and disease are related.

Select Drug Character Offset Drug Term Instance
Insulin 14152 technique. Intriguingly, the title of the paper is ‘Moderate Amounts of Fructose Consumption Impair Insulin Sensitivity in Healthy Young Men’, but the results obtained show that the only change in insulin sensitivity
Select Disease Character Offset Disease Term Instance
diabetes mellitus 4626 insulin resistance and impaired glucose tolerance and lead to an increased risk of developing type 2 diabetes mellitus (DM). There is increasing concern about the potential threat to health represented by a high intake
diabetes mellitus 24196 evidence of an association between diets differing in the proportion of sugars and the incidence of type 2 diabetes mellitus .A balanced overview of the current position regarding potential health problems arising from fructose/sucrose
metabolic syndrome 7948 can lead to excessive lipid formation and deposition, insulin resistance and other features of the metabolic syndrome . However, the studies which have investigated potential effects of fructose on liver fat content, plasma
metabolic syndrome 9173 ecological observations. An example of this is provided by Johnson et al. [[9]] who reviewed studies in metabolic syndrome prone rats that developed fatty livers whilst receiving 40% of their dietary energy from sucrose. This
obesity 429 of major concern. The focus of this review is the impact of these sugars on insulin resistance and obesity , and the associated risk of developing type 2 diabetes. Much of the concern is focussed on specific
obesity 1648 associated with detrimental effects on metabolism that increase the risk of cardiovascular disease, obesity , insulin resistance and diabetes. Some of the evidence underpinning these concerns is derived from cross-sectional
obesity 8351 below). Longitudinal cohort studies and ecological observations have been used to associate increased obesity with high levels of sucrose, fructose or HFCS consumption. For example, Fiorito et al. [[7]] reported
obesity 11145 with fructose/sucrose in people. Klurfeld et al. [[13]] assessed the potential link between HFCS and obesity and concluded that the evidence was not supportive of such a claim and commented that RCT at levels
obesity 11354 even exceeding normal human consumption have also been inconclusive related to fructose, sucrose and obesity . A subsequent review by Tappy and Mittendorfer [[14]] commented that whilst some studies describe potential
obesity 23736 an increased risk of developing type 2 DM, or just an increased risk of weight gain and eventually obesity , cannot be determined from these short-term RCT.It is interesting to note that the SACN report also
obesity 24631 specific problems which have been identified in relation to sugars-sweetened beverages and risk of obesity are a result of energy overconsumption rather than any effect of fructose on energy metabolism or storage.
obesity 24987 activity to increase energy expenditure, represent the lifestyle changes needed to address the current obesity problem in many countries. Clearly, the recent observation of potential effects of modest amounts of
type 2 diabetes mellitus 4619 lead to insulin resistance and impaired glucose tolerance and lead to an increased risk of developing type 2 diabetes mellitus (DM). There is increasing concern about the potential threat to health represented by a high intake
type 2 diabetes mellitus 24189 evidence of an association between diets differing in the proportion of sugars and the incidence of type 2 diabetes mellitus .A balanced overview of the current position regarding potential health problems arising from fructose/sucrose

You must be authorized to submit a review.