Insufficient documentation for clinical efficacy of selenium supplementation in chronic autoimmune thyroiditis, based on a systematic review and meta-analysis

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Annotation Summary

Term Occurence Count Dictionary
autoimmune thyroiditis 4 endocrinologydiseases
hypothyroidism 8 endocrinologydiseases
thyroglobulin 1 endocrinologydiseasesdrugs
thyroiditis 5 endocrinologydiseases

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Select Drug Character Offset Drug Term Instance
thyroglobulin 31183 eligibility criteria set for trial participants. In euthyroid individuals, whose tolerance to TPO or thyroglobulin is broken, but where clinical disease is absent, we recommend disease progression as an important outcome.
Select Disease Character Offset Disease Term Instance
autoimmune thyroiditis 104 Title: EndocrineInsufficient documentation for clinical efficacy of selenium supplementation in chronic autoimmune thyroiditis , based on a systematic review and meta-analysisKristian Hillert WintherJohanna Eva Märta WichmanSteen
autoimmune thyroiditis 501 meta-analysis to investigate clinically relevant effects of selenium supplementation in patients with chronic autoimmune thyroiditis . Controlled trials in adults (≥18 years) with autoimmune thyroiditis, comparing selenium with or
autoimmune thyroiditis 574 supplementation in patients with chronic autoimmune thyroiditis. Controlled trials in adults (≥18 years) with autoimmune thyroiditis , comparing selenium with or without levothyroxine substitution, versus placebo and/or levothyroxine
autoimmune thyroiditis 2308 health-related quality of life, are warranted before determining the relevance of selenium supplementation in autoimmune thyroiditis .IntroductionChronic autoimmune (AIT) or Hashimoto’s thyroiditis affects 1–2 % of the population
hypothyroidism 2569 and a female preponderance. In communities replete in iodine intake, it is the predominant cause of hypothyroidism [[1], [2]]. The etiology is multifactorial and based on genetic susceptibility in a complex interaction
hypothyroidism 14399 of 30 patients in the control and 2 of 31 patients in the intervention group, developed subclinical hypothyroidism during the months of follow-up. Pilli et al. [[20]] reported subclinical hypothyroidism in 2 of 20 patients
hypothyroidism 14487 subclinical hypothyroidism during the months of follow-up. Pilli et al. [[20]] reported subclinical hypothyroidism in 2 of 20 patients in the control group vs. 2 of 40 patients in the selenium groups. The difference
hypothyroidism 17004 indirectnessSerious imprecision (small sample size)Undetected+++Moderatea Defined as the development of hypothyroidism during the course of a trialTable 3Risk of bias of included trials1 Blinding: Unclear risk of bias for
hypothyroidism 25520 remission are rated as crucial according to the GRADE recommendations, and of obvious concern, since hypothyroidism is associated with increased somatic [[44]] and psychiatric morbidity [[45]], as well as excess mortality
hypothyroidism 27051 outcome. It can be evaluated categorically by the proportion of patients developing subclinical or overt hypothyroidism during the time of intervention or follow-up. Two studies reported direct data for this aspect [[20],
hypothyroidism 28626 12 weeks gestation to 12 months after delivery [[28]]. Post partum thyroid dysfunction and permanent hypothyroidism were significantly less prevalent in patients receiving selenium, as compared to placebo. Based on this,
hypothyroidism 28857 concluded that selenium supplementation reduced thyroid inflammatory activity and the incidence of hypothyroidism in the post partum phase [[28]].Seven of the included nine trials reported selenium status in their
thyroiditis 115 EndocrineInsufficient documentation for clinical efficacy of selenium supplementation in chronic autoimmune thyroiditis , based on a systematic review and meta-analysisKristian Hillert WintherJohanna Eva Märta WichmanSteen
thyroiditis 512 investigate clinically relevant effects of selenium supplementation in patients with chronic autoimmune thyroiditis . Controlled trials in adults (≥18 years) with autoimmune thyroiditis, comparing selenium with or
thyroiditis 585 patients with chronic autoimmune thyroiditis. Controlled trials in adults (≥18 years) with autoimmune thyroiditis , comparing selenium with or without levothyroxine substitution, versus placebo and/or levothyroxine
thyroiditis 2319 quality of life, are warranted before determining the relevance of selenium supplementation in autoimmune thyroiditis .IntroductionChronic autoimmune (AIT) or Hashimoto’s thyroiditis affects 1–2 % of the population
thyroiditis 2385 selenium supplementation in autoimmune thyroiditis.IntroductionChronic autoimmune (AIT) or Hashimoto’s thyroiditis affects 1–2 % of the population with increasing prevalence with age and a female preponderance.

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