Lactate, a Neglected Factor for Diabetes and Cancer Interaction.

Existing Reviews

Please note, new claims can take a short while to show up.

No claims yet.

Annotation Summary

Term Occurence Count Dictionary
hyperglycemia 1 endocrinologydiseases
hyperinsulinemia 4 endocrinologydiseases
lactic acidosis 1 endocrinologydiseases
metabolic syndrome 2 endocrinologydiseases
obesity 5 endocrinologydiseases
Insulin 3 endocrinologydiseasesdrugs
diabetes mellitus 1 endocrinologydiseases

Graph of close proximity drug and disease terms (within 200 characters).

Note: If this graph is empty, then there are no terms that meet the proximity constraint.

Review

Having read the paper, please pick a pair of statements from the paper to indicate that a drug and disease are related.

Select Drug Character Offset Drug Term Instance
Insulin 8800 these patients relative to healthy controls and blood lactate level rises under this condition [[36]]. Insulin resistance plays a vital role in the pathogenesis of T2DM [[46]] and can be used as an early marker
Insulin 9565 insulin resistance since hyperinsulinemia induces enhanced glycolysis.4. Contribution of Lactate to Insulin Resistance/DiabetesAs an imperative cellular metabolite in the glycolytic pathway, lactate might reflect
Insulin 28882 with each other in a vicious cycle, where lactate plays a pivotal role in this mutual interaction. Insulin resistance/diabetes and cancer conditions produce high levels of lactate and conversely high lactate
Select Disease Character Offset Disease Term Instance
diabetes mellitus 1853 novel preventive and therapeutic approaches for diabetes and cancer treatment.1. IntroductionGlobally, diabetes mellitus (DM) and cancer are two of the most predominant diseases, with cancer the 2nd and diabetes the 12th
hyperglycemia 2693 is yet to emerge, several mechanisms have been suggested to explain this relationship, for example, hyperglycemia itself [[3]], oxidative stress [[8]–[11]], treatment for diabetes, hormonal disorders, insulin resistance
hyperinsulinemia 2830 stress [[8]–[11]], treatment for diabetes, hormonal disorders, insulin resistance with secondary hyperinsulinemia [[3]], metabolic alterations underlying the diseases [[12]], insulin-increased bioactivity of IGF-I
hyperinsulinemia 7534 lactate production progressively rises during hyperinsulinemic euglycemic clamp study, a condition of hyperinsulinemia similar to the early stages in the development of T2DM. Intriguingly, similar previous studies also
hyperinsulinemia 7748 also report elevated lactate concentrations during the early stages of diabetes, prediabetes, and the hyperinsulinemia condition. In addition, Brouwers et al. [[41]] reported increased lactate levels in patients with poorly
hyperinsulinemia 9490 generation from NADH in a redox reaction. This reaction may be accentuated in insulin resistance since hyperinsulinemia induces enhanced glycolysis.4. Contribution of Lactate to Insulin Resistance/DiabetesAs an imperative
lactic acidosis 18839 stromal cells [[18]]. In addition, it decreases extracellular pH to 6.0–6.5 [[94]–[96]]. Actually, lactic acidosis frequently contributes to death in patients with some types of metastatic cancer, for example, metastatic
metabolic syndrome 27204 development.It is believed that in diabetic patients, the adipose tissue plays a major role in induction of metabolic syndrome . In these patients there is an underlying chronic inflammation in adipose tissue and a general increase
metabolic syndrome 28162 melanoma [[166]]. These findings indicate that the release cytokines may play roles in both cancer and metabolic syndrome and may be the connecting points between developments of both diseases.7. Concluding Remarks and Future
obesity 3056 [14]], insulin's positive effect on estrogen bioavailability, the status of chronic inflammation, and obesity [[7]]. On the other hand, DM might also develop after tumor establishment in certain cancers that progress
obesity 7141 patients with DM including T1DM and T2DM versus nondiabetic persons [[28]–[36]]. Diabetic patients with obesity exhibit higher fasting plasma lactate levels than nondiabetic individuals with obesity [[37], [38]].
obesity 7228 patients with obesity exhibit higher fasting plasma lactate levels than nondiabetic individuals with obesity [[37], [38]]. Barnett et al. proposed that diabetes-associated hyperlactatemia might be an early change
obesity 9764 might reflect the cellular metabolism status. Some studies suggest that augmented lactate levels in obesity , which might play a significant role in glucose transport and metabolism, profoundly influence insulin
obesity 10947 improves DM symptoms. Instead, lactate concentrations are chronically increased in diabetic patients with obesity [[52]]. The chronical hyperlactatemia maintained by the enhanced lactate formation from adipocytes in

You must be authorized to submit a review.