Relationship between Advanced Glycation End Products and Steroidogenesis in PCOS

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Term Occurence Count Dictionary
hyperglycemia 2 endocrinologydiseases
obesity 1 endocrinologydiseases
ovarian dysfunction 2 endocrinologydiseases
polycystic ovary syndrome 1 endocrinologydiseases
testosterone 7 endocrinologydiseasesdrugs
Insulin 1 endocrinologydiseasesdrugs
estrone 1 endocrinologydiseasesdrugs
hyperandrogenism 9 endocrinologydiseases

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Select Drug Character Offset Drug Term Instance
Insulin 40780 diet with or without AGEs, increased adiposity was noted in animals fed diet-containing AGEs [[81]]. Insulin resistant women with PCOS without hyperglycemia have elevated serum levels of AGEs and upregulation
estrone 28740 encoded by CYP19A1 gene, is a microsomal enzymatic complex that catalyzes the formation of estrogens ( estrone and E2) from androgens (androstenedione and T) during steroidogenesis [[59]]. LH stimulates steroidogenesis
testosterone 2789 in serum androgens such as dehydroepiandrosterone (DHEA), DHEA sulfate (DHEAS), androstenedione, and testosterone (T) is observed due to abnormally increased ovarian and adrenal production [[10]–[15]]. Elevation
testosterone 9857 enzymes. The binding of AGEs to RAGE induces several steroidogenic enzymes which might lead to increase in testosterone production. Green color represents induction. StAR: Steroidogenic Acute Regulatory protein, P450scc:
testosterone 13072 ovariesHogg et al., 2012 [[49]]- 11 months-old female offspring of ewe PCO-model induced by prenatal testosterone propionate (TP) (n = 9)- Age-matched control ewe (n = 5)- StAR gene expression- Androstenedione
testosterone 17280 3β-HSD 3beta-hydroxysteroid dehydrogenase, CYP17A1 17α-hydroxylase, hCG human chorionic gonadotropin, T testosterone , IVF in vitro fertilization, GIFT gamete intra-fallopian transfer, E2 estradiol, P4 progesterone, RT-PCR
testosterone 37005 modification with intake of diet containing low AGEs can reduce the concentration of plasma bioavailable testosterone and can modify PCOS phenotypes [[21], [79]].Table 2Studies evaluating the association between AGEs and
testosterone 40167 glycation end products, ART Assisted Reproductive Technology, CML carboxymethyl lysine, E2 Estradiol, T testosterone , AMH anti-Mullerian hormone, AMHR-II AMH receptor, sRAGE soluble receptor for AGEs, IVF in vitro fertilizationObesity
testosterone 41008 in their circulating monocytes [[27]]. Additionally, serum AGE levels are positively correlated with testosterone level, free androgen index, insulin, HOMA and waist-to-hip ratio in women with PCOS who did not have
Select Disease Character Offset Disease Term Instance
hyperandrogenism 1181 function thus adversely impacting steroidogenesis and follicular development. AGEs are associated with hyperandrogenism in PCOS possibly by altering the activity of various enzymes such as cholesterol side-chain cleavage
hyperandrogenism 1952 syndrome (PCOS) is one of the most common endocrine disorders in reproductive-aged women [[1]] causing hyperandrogenism (clinical and/or biochemical), and oligo/anovulation [[2], [3]]. Hyperandrogenism could be responsible
hyperandrogenism 2171 for some of the clinical features of PCOS such as hirsutism [[4]]. Although the exact mechanism of hyperandrogenism in PCOS is not clear, it is well known that ovaries of women with PCOS have alterations in steroidogenesis
hyperandrogenism 5774 conducted. We used the following search terms: “PCOS,” “steroidogenesis,” “enzyme,” “ hyperandrogenism ,” “hormone,” “AGEs,” “RAGE,” and “soluble receptor for AGEs (sRAGE), cholesterol side-chain
hyperandrogenism 8362 al. [[36]] showed dysregulation of granulosa cells in addition to intrinsic dysfunction leading to hyperandrogenism and increased expression of FSH receptor (FSHR) and androgen receptor (AR) in stimulated ovaries of
hyperandrogenism 34297 endothelial cells and granulosa cell layer of PCOS ovaries [[74]].Fig. 3Relationship between AGEs and hyperandrogenism in PCOS. The elevation in serum AGEs and the overexpression of ovarian RAGE in PCOS are associated with
hyperandrogenism 34418 PCOS. The elevation in serum AGEs and the overexpression of ovarian RAGE in PCOS are associated with hyperandrogenism . AGEs, advanced glycation end products; RAGE, receptor for advanced glycation end productsThe abnormal
hyperandrogenism 36822 compared to L-AGE diet fed animals [[78]]. These studies substantiate the association between AGEs and hyperandrogenism in PCOS. Accumulating evidence has demonstrated that dietary modification with intake of diet containing
hyperandrogenism 46437 that contribute to altered steroidogenesis in polycystic ovaries. If exact mechanism of AGEs induced hyperandrogenism in PCOS is established, the targeted therapy against AGEs will be beneficial to improve the reproductive
hyperglycemia 40822 adiposity was noted in animals fed diet-containing AGEs [[81]]. Insulin resistant women with PCOS without hyperglycemia have elevated serum levels of AGEs and upregulation in RAGE expression in their circulating monocytes
hyperglycemia 41122 level, free androgen index, insulin, HOMA and waist-to-hip ratio in women with PCOS who did not have hyperglycemia [[82]]. Another study has shown that increased serum AGE levels is observed in non-insulin resistant
obesity 40442 in women with PCOS [[1]]. Recent studies have demonstrated a role for AGEs in the development of obesity [[80], [81]]. For example in one study, after feeding C57/BL6 and db/db mice with H-AGE or L-AGE diet
ovarian dysfunction 1766 contribute meaningfully to a conceptual framework whereby new interventions to prevent and/or treat ovarian dysfunction in PCOS can ultimately be developed.BackgroundPolycystic ovary syndrome (PCOS) is one of the most common
ovarian dysfunction 46708 AGEs seem to affect ovarian steroid production. Understanding the role of the AGE-RAGE/sRAGE axis in ovarian dysfunction , particularly in women with PCOS who have elevated levels of these AGEs, might shed light for better
polycystic ovary syndrome 16996 Mutations of the P450arom gene or its promoter were not found to be associated with PCOSAbbreviations: PCOS polycystic ovary syndrome , FSH Follicle-stimulating hormone, LH luteinizing hormone, P450scc cholesterol side-chain cleavage enzyme,

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