The Sulfur Metabolite Lanthionine: Evidence for a Role as a Novel Uremic Toxin.

Existing Reviews

Please note, new claims can take a short while to show up.

No claims yet.

Annotation Summary

Term Occurence Count Dictionary
cystinuria 2 endocrinologydiseases
enalapril 2 endocrinologydiseasesdrugs
homocystinuria 2 endocrinologydiseases
hyperhomocysteinemia 6 endocrinologydiseases

Graph of close proximity drug and disease terms (within 200 characters).

Note: If this graph is empty, then there are no terms that meet the proximity constraint.

Review

Having read the paper, please pick a pair of statements from the paper to indicate that a drug and disease are related.

Select Drug Character Offset Drug Term Instance
enalapril 3537 addition, Xu et al. reported findings from a prespecified CSPPT substudy demonstrating that folic acid plus enalapril was more effective than enalapril alone in the secondary prevention of renal function decline in mild-to-moderate
enalapril 3571 a prespecified CSPPT substudy demonstrating that folic acid plus enalapril was more effective than enalapril alone in the secondary prevention of renal function decline in mild-to-moderate chronic kidney disease
Select Disease Character Offset Disease Term Instance
cystinuria 18931 The latter condition may mimic the consequences of chronic CBS-impairing mutations underpinning homo cystinuria [[9]]. Conversely, in hemodialysis patients, both oxidative stress and cystathionine are increased [[10]].Figure
cystinuria 19913 heme oxygenase 1 (HO-1)—may inhibit CBS under stress conditions (also possibly associated with homo cystinuria due to CBS mutations or deletions), thus creating the conditions for a relative decrease of the complete
homocystinuria 18927 cysteine. The latter condition may mimic the consequences of chronic CBS-impairing mutations underpinning homocystinuria [[9]]. Conversely, in hemodialysis patients, both oxidative stress and cystathionine are increased [[10]].Figure
homocystinuria 19909 of heme oxygenase 1 (HO-1)—may inhibit CBS under stress conditions (also possibly associated with homocystinuria due to CBS mutations or deletions), thus creating the conditions for a relative decrease of the complete
hyperhomocysteinemia 1568 fold. Uremic patients display a derangement of sulfur amino acid metabolism with a high prevalence of hyperhomocysteinemia . Uremia is associated with a high cardiovascular mortality, the causes of which are still not completely
hyperhomocysteinemia 2949 disease. One of the most classical findings, which is almost constantly associated with uremia, is hyperhomocysteinemia , the causative role of which has been debated, although the rationale for its inclusion in the list
hyperhomocysteinemia 11881 lanthionine in uremia could explain the H2S reduction and contribute at least in part to the degree of hyperhomocysteinemia in uremia, thus providing for a mechanism in the pathophysiology of this derangement.4.2. Lanthionine
hyperhomocysteinemia 15959 stability of the LanCL1-CBS complex, thus increasing the inhibitory function of LanCL1 on CBS, leading to hyperhomocysteinemia (Figure 3 and Figure 4). It has been in fact suggested that hyperhomocysteinemia in uremia may be due
hyperhomocysteinemia 16040 on CBS, leading to hyperhomocysteinemia (Figure 3 and Figure 4). It has been in fact suggested that hyperhomocysteinemia in uremia may be due to inhibition, by an unknown uremic toxin, of homocysteine-metabolizing enzymes,
hyperhomocysteinemia 16432 levels of this compound found in uremic patients could contribute at least in part to the degree of hyperhomocysteinemia in uremia, thus providing a mechanism in the pathophysiology of this derangement, which is still not

You must be authorized to submit a review.