Fatty liver is associated with an increased risk of diabetes and cardiovascular disease - Evidence from three different disease models: NAFLD, HCV and HIV

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Annotation Summary

Term Occurence Count Dictionary
metabolic syndrome 2 endocrinologydiseases
obesity 3 endocrinologydiseases
glucose intolerance 1 endocrinologydiseases
hyperlipidemia 2 endocrinologydiseases
lipodystrophy 1 endocrinologydiseases
maraviroc 1 endocrinologydiseasesdrugs

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Select Drug Character Offset Drug Term Instance
maraviroc 47133 are lacking. A very small series of 10 HIV mono-infected VAFLD patients, who were treated either with maraviroc (MRV) plus atazanavir (n = 7) or with vitamin E (n = 3), found that at baseline the histologic degree
Select Disease Character Offset Disease Term Instance
glucose intolerance 39083 challenges for patient care. Cardio metabolic complications, such as CVD, atherogenic dyslipidemia and glucose intolerance /T2D, are very common in older HIV-infected patients, and justify the onset of multidisciplinary metabolic
hyperlipidemia 7190 Prevalence of NAFLD in those with a given metabolic condition)Hyperlipidemia69%Obesity98%Obesity51%Mixed hyperlipidemia with elevated serum ALT levels83%MetS42%T2D70%Hypertension39%Mixed hyperlipidemia60%T2D22%MetS70%Hypertension50%ALT:
hyperlipidemia 7272 condition)Hyperlipidemia69%Obesity98%Obesity51%Mixed hyperlipidemia with elevated serum ALT levels83%MetS42%T2D70%Hypertension39%Mixed hyperlipidemia 60%T2D22%MetS70%Hypertension50%ALT: Alanine transaminase; MetS: Metabolic syndrome; T2D: Type 2 diabetes.The
lipodystrophy 47870 unpublished data). However, future large randomized clinical trials are needed to confirm these findings.As lipodystrophy may predispose HIV-infected patients to develop T2D and other MetS features, new prevention and management
metabolic syndrome 3146 in individuals without excessive alcohol consumption and who have (or will develop) features of the metabolic syndrome (MetS)[[3],[4]]. Chronic hepatitis C virus (HCV) infection is also commonly associated with fatty liver,
metabolic syndrome 32334 developed a set of metabolic abnormalities collectively referred to as “hepatitis C-associated dys metabolic syndrome ” (HCADS)[[171]]. HCADS includes fatty liver, hyperuricaemia, hypocholesterolaemia, IR, hypertension
obesity 6256 evolution, owing to ovarian senescence and estrogen deficiency[[13],[14]].It is known that abdominal obesity /overweight, T2D and other MetS features are strongly associated with an increased risk of NAFLD. However,
obesity 18226 may protect mice from diet-induced fatty liver and hepatic and peripheral IR[[95]].In the setting of obesity or T2DM/pre-diabetes, the presence of NAFLD often develops in concert with homologous fatty changes
obesity 32479 includes fatty liver, hyperuricaemia, hypocholesterolaemia, IR, hypertension and visceral overweight/ obesity . Such metabolic disorders may best be interpreted as a “Darwinian strategy”, favoring HCV survival

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