Pregnancy and acromegaly.

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Term Occurence Count Dictionary
bromocriptine 4 endocrinologydiseasesdrugs
cabergoline 4 endocrinologydiseasesdrugs
diabetes mellitus 2 endocrinologydiseases
hypogonadism 1 endocrinologydiseases
acromegaly 43 endocrinologydiseases

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bromocriptine 13643 were obtained by Ricci et al. from women with prolactinomas, however [[22]]. Short-term treatment with bromocriptine has not been found to cause any increase in spontaneous abortions, ectopic pregnancies, trophoblastic
bromocriptine 13938 et al. [[26]] reported a case of acromegaly diagnosed in the second trimester of pregnancy, in which bromocriptine corrected visual field defects and suppressed prolactin secretion but did not reduce fasting growth
bromocriptine 14209 reported a case of an acromegalic patient with galactorrhea-amenorrhea who conceived following long-term bromocriptine therapy. They showed that bromocriptine can restore ovulatory function not only to the patient with
bromocriptine 14249 with galactorrhea-amenorrhea who conceived following long-term bromocriptine therapy. They showed that bromocriptine can restore ovulatory function not only to the patient with a hypothalamic disorder but also to acromegalic
cabergoline 13528 pregnancy.Most data on safety of the use of dopamine agonists during 61 pregnancies in 50 women treated with cabergoline were obtained by Ricci et al. from women with prolactinomas, however [[22]]. Short-term treatment with
cabergoline 14407 the patient with a hypothalamic disorder but also to acromegalic patients.Experience with the use of cabergoline in pregnancy is limited [[28]]. Ricci et al. [[28]] collected information on 61 pregnancies in 50 women
cabergoline 14536 limited [[28]]. Ricci et al. [[28]] collected information on 61 pregnancies in 50 women treated with cabergoline . These pregnancies resulted in 12 (19.7 %) early terminations (five induced abortions, six spontaneous
cabergoline 14871 more or less exclude a major congenital malformation risk >10 % associated with pregnancy exposure to cabergoline [[28]–[30]].Safety aspects of using somatostatin analogs during pregnancyMaffei et al. [[31]] reported
Select Disease Character Offset Disease Term Instance
acromegaly 30 Title: PituitaryPregnancy and acromegaly Ammar MuhammadSebastian J. NeggersAart J. van der LelyPublication date (epub): 8/2016Publication date
acromegaly 364 high incidence of secondary hypogonadism, pregnancies are relatively rare. However, some women with acromegaly do get pregnant, which brings along questions about medication, complications and follow-up. This review
acromegaly 1020 takes over the control over GH and IGF-1, not only in normal physiology but also to a certain extend in acromegaly . When medication for the high GH levels or actions is continued during pregnancy, both dopamine agonists,
acromegaly 2443 two changes are probably the main reasons behind the apparent lack of biochemical escape in pregnant acromegaly patients when medical treatment is stopped [[4]].Therefore, it is commonly not necessary to continue
acromegaly 2584 treatment is stopped [[4]].Therefore, it is commonly not necessary to continue medical treatment for active acromegaly during pregnancies. In this review, we try to address the (patho)physiological metabolic background
acromegaly 2735 try to address the (patho)physiological metabolic background of normal pregnancy versus pregnancy in acromegaly patients. Also we discuss the available safety data of medical treatment modalities for acromegaly.What
acromegaly 2834 acromegaly patients. Also we discuss the available safety data of medical treatment modalities for acromegaly .What is different and what is identical in the hormonal patterns between normal pregnancies and the
acromegaly 2953 different and what is identical in the hormonal patterns between normal pregnancies and the ones in acromegaly In a nice overview by Verhaeghe [[5]], it is explained in detail that normal pregnancies are accompanied
acromegaly 3756 (20–25 %) increase in the course of pregnancy [[5]]. All-in-all, during normal pregnancy a ‘gestational acromegaly ’ develops in order to foster fetoplacental growth.Placental and maternal pituitary hormones tightly
acromegaly 4167 factors that usually inhibit pituitary GH secretion during the second part of normal pregnancy. In acromegaly , the decrease of IGF-I in the first trimester of pregnancy may be related to decreased production or
acromegaly 5020 Persechini et al. [[2]]. While this phenomenon is present in normal pregnancies, it’s also present in acromegaly . Administration of high doses of estrogens to patients with acromegaly has been shown already more than
acromegaly 5091 pregnancies, it’s also present in acromegaly. Administration of high doses of estrogens to patients with acromegaly has been shown already more than 50 years ago to improve symptomatology of acromegaly and glucose tolerance
acromegaly 5178 patients with acromegaly has been shown already more than 50 years ago to improve symptomatology of acromegaly and glucose tolerance [[8]]. Selective estrogen receptor modulators (SERMs) mimic the effects of estrogen
acromegaly 5491 breast tissue [[9]]. Balili and Barkan [[9]] evaluated hormonal effects of the SERM tamoxifen in 15 male acromegaly patients with active disease and 2 post-menopausal women, also with biochemically-active acromegaly
acromegaly 5591 acromegaly patients with active disease and 2 post-menopausal women, also with biochemically-active acromegaly despite the fact that other modalities were ineffective in normalizing their IGF-1 levels. They observed
acromegaly 6548 negative interference of pregnancy serum in their GH-IFMA assay. Addition of pregnancy serum to ‘ acromegaly ’ serum resulted in a marked decrease in GH, but addition of pGH did not change GH measurements [[10]].
acromegaly 7269 important for healthy fetal growth. Therefore, the lack of fetal abnormalities in children born out of acromegaly mothers shows that, apparently, the normal physiological drivers seem to control the autonomous GH secretion
acromegaly 8220 pulmonary surfactant [[12]].The conceptual changes during pregnancy in normal subjects and women with acromegaly are shown in Fig. 1.Fig. 1Semi-qualitative conceptual changes in GH, IGF-I and placental GH (pGH)
acromegaly 8390 changes in GH, IGF-I and placental GH (pGH) during normal pregnancy and during pregnancy in women with acromegaly , based on [[4], [5], [7]]What happens if medical treatment is stopped?The reasons behind the apparent
acromegaly 8542 medical treatment is stopped?The reasons behind the apparent lack of biochemical escape in pregnant acromegaly patients when medical treatment is stopped were already addressed by Beckers et al. [[4]]. They described
acromegaly 9473 somatotrophs lack an IGF-I-dependent feedback regulation present in normal somatotrophs [[4]].Most acromegaly patients who become pregnant while on medical therapy in fact represent patients in which the fetus
acromegaly 9896 fetus. Also there is a complete lack of data on safety in those who start taking medication to control acromegaly , as the indication for this is extremely rare.Because of the overlap between the normal gestational
acromegaly 10007 as the indication for this is extremely rare.Because of the overlap between the normal gestational acromegaly and pregnancy in acromegaly, the distinction between the two more or less disappears. In a recent prospective
acromegaly 10035 is extremely rare.Because of the overlap between the normal gestational acromegaly and pregnancy in acromegaly , the distinction between the two more or less disappears. In a recent prospective study in 10 pregnancies
acromegaly 10157 distinction between the two more or less disappears. In a recent prospective study in 10 pregnancies in 8 acromegaly patients, in whom medication for acromegaly was stopped immediately following confirmation of pregnancy,
acromegaly 10201 disappears. In a recent prospective study in 10 pregnancies in 8 acromegaly patients, in whom medication for acromegaly was stopped immediately following confirmation of pregnancy, Dias et al. [[13]] describe that no tumor
acromegaly 11002 as GH and IGF-1 don’t seem to cross the placenta [[14]].Tumor size is another important issue in acromegaly . Stopping medication might have clinical consequences for the patient when tumor size increases. Only
acromegaly 11522 during pregnancy [[17]].In a recent review Cheng et al. [[18]] also reported that most patients with acromegaly during pregnancy do not have an increase in tumor size, and metabolic complications are uncommon.Caron
acromegaly 11731 uncommon.Caron et al. [[19]] reported on a retrospective multicenter study of 59 pregnancies in 46 women with acromegaly that pregnancy in women with active or uncontrolled acromegaly may be associated with an increased risk
acromegaly 11794 study of 59 pregnancies in 46 women with acromegaly that pregnancy in women with active or uncontrolled acromegaly may be associated with an increased risk of as already mentioned not only gestational diabetes but also
acromegaly 12643 10–18 weeks earlier before GDM is typically screened for. The risk of GDM seems to be increased in acromegaly as GDM was diagnosed in four of the 59 pregnancies (6.8 %) in the series reported by Caron et al. [[19]].
acromegaly 12844 Caron et al. [[19]]. Three of these four women did not have diabetes mellitus before pregnancy, whereas acromegaly was diagnosed during pregnancy in the fourth woman, and the existence of diabetes mellitus before pregnancy
acromegaly 13870 multiple pregnancies, or congenital malformations [[23]–[25]]. Yap et al. [[26]] reported a case of acromegaly diagnosed in the second trimester of pregnancy, in which bromocriptine corrected visual field defects
acromegaly 15408 occur by passive diffusion [[31], [32]]. Fassnacht et al. reported a 24-year-old woman with active acromegaly despite pituitary surgery and irradiation who received continuous octreotide LAR treatment for the control
acromegaly 15699 girl following an uneventful pregnancy [[33]]. Takano et al. reported a 35-year-old woman with active acromegaly who also received continuous octreotide LAR treatment for the control of GH excess until discovery of
acromegaly 16063 early phase of pregnancy [[34]].Neal [[35]] reported a successful pregnancy in a 43-year-old woman with acromegaly and treatment during pregnancy with octreotide. This patient decided to continue octreotide therapy
acromegaly 16545 other women, who used octreotide during the first trimester of pregnancy in seven other women with acromegaly (and throughout pregnancy in one) [[35]]. No adverse effects on the fetus were observed [[35]]. Also,
acromegaly 17412 pregnancyVan der Lely et al. [[36]] summarized all available data on pregnancy outcome of 35 casus of acromegaly patients exposed to pegvisomant (PEGV) during pregnancy as present in the Pfizer’s Global Safety Database
acromegaly 17959 unless absolutely necessary. Riddle Brian et al. already reported a case of a 26-year-old female with acromegaly who had failed surgical and subsequent medical therapy but whose disease was well controlled on PEGV
acromegaly 18905 over maternal GH and IGF-1 secretion, not only in normal physiology but also to a certain extend in acromegaly .During normal pregnancy, placental GH rises exponentially until 37 weeks. Meanwhile, pituitary GH gradually
acromegaly 19279 the second half, again with a peak at around 37 weeks.The question is whether or not patients with acromegaly should be treated for the disease during pregnancy anyway. The consensus is, however, that there is
acromegaly 19468 however, that there is no indication to use medication to control GH hypersecretion or tumor size in acromegaly patients during pregnancy.When for whatever reason medication for the high GH levels or actions is continued
acromegaly 20279 conception, although data to support a positive effect of this are lacking. This also accounts for male acromegaly fathers to be.When pregnancy is confirmed, medical treatment can be stopped in almost every patient,
diabetes mellitus 12800 pregnancies (6.8 %) in the series reported by Caron et al. [[19]]. Three of these four women did not have diabetes mellitus before pregnancy, whereas acromegaly was diagnosed during pregnancy in the fourth woman, and the existence
diabetes mellitus 12928 pregnancy, whereas acromegaly was diagnosed during pregnancy in the fourth woman, and the existence of diabetes mellitus before pregnancy could not be ascertained [[19]].Cheng et al. [[21]] report in 13 newly described pregnancies
hypogonadism 292 /2017AbstractIntroductionAcromegaly is a rare disorder in which, due to the high incidence of secondary hypogonadism , pregnancies are relatively rare. However, some women with acromegaly do get pregnant, which brings

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