A Systematic Review of Biomarkers and Risk of Incident Type 2 Diabetes: An Overview of Epidemiological, Prediction and Aetiological Research Literature.

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diabetes mellitus 1 endocrinologydiseases
obesity 5 endocrinologydiseases
testosterone 1 endocrinologydiseasesdrugs

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testosterone 38100 been stored for several years. Our review process may have failed to identify other biomarkers (e.g., testosterone , a sex hormone [[53]]) or all studies on the same biomarker if the authors did not explicitly mention
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diabetes mellitus 8409 diabetes); (ii) investigated only single nucleotide polymorphisms (SNPs); (iii) included only gestational diabetes mellitus or a complication of diabetes (like cardiovascular disease) as the main outcome; (iv) were restricted
obesity 3717 relevant data are within the paper and its Supporting Information files.IntroductionThe pandemic of obesity and type 2 diabetes (T2D) is a global public health and health policy issue [[1]]. The development of
obesity 6374 biomarkers that are associated with the risk of incident T2D in the population as a whole and within obesity strata. We did not include cross-sectional studies because of the limitations of such studies in enabling
obesity 10441 adjustment, magnitude of an estimated effect, statistical significance, and stratified analysis by obesity strata).Data were extracted independently and discrepancies were resolved by discussion. We tabulated
obesity 21039 interaction with BMI, was undertaken with 17 studies of 19 individual biomarkers. The definition of obesity strata varied between studies and 12 biomarkers were statistically associated with diabetes risk in
obesity 36685 in this sub-group or how they can inform aetiological understanding of the metabolic consequences of obesity . However, our review was not confined to studies of obese participants because many studies of the general

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