Nonalcoholic fatty liver disease - A multisystem disease?

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Term Occurence Count Dictionary
hyperuricemia 1 endocrinologydiseases
metabolic syndrome 5 endocrinologydiseases
obesity 21 endocrinologydiseases
testosterone 1 endocrinologydiseasesdrugs
Insulin 2 endocrinologydiseasesdrugs
diabetes mellitus 3 endocrinologydiseases
hyperandrogenism 1 endocrinologydiseases

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Select Drug Character Offset Drug Term Instance
Insulin 19002 attempt to repair the endothelial damage resulting from metabolic alterations accompanying NAFLD[[83]]. Insulin resistance is a crucial contributor to NAFLD, MetS and atherosclerosis. Increased liver fat content
Insulin 52689 clinical and/or laboratorial hyperandrogenism. Hyperinsulinemia is very common amongst women with PCOS. Insulin and luteinizing hormone act synergistically, stimulating ovarian theca cells to increase androgen synthesis,
testosterone 52938 steroid hormone binding globulin by the liver and increasing the amount of free and biologically active testosterone in circulation. Because IR is the characteristic of MetS, several reports have shown that women with
Select Disease Character Offset Disease Term Instance
diabetes mellitus 1036 negatively associated with a range of chronic diseases, most notably cardiovascular disease (CVD), diabetes mellitus type 2 (T2DM) and chronic kidney disease (CKD). It is becoming increasingly clear that these diseases
diabetes mellitus 2915 frequent form of chronic liver disease that is closely related to MetS and its individual components [ diabetes mellitus type 2 (T2DM), dyslipidemia, obesity and arterial hypertension]. NAFLD is diagnosed in people who do
diabetes mellitus 17777 linking obesity, nonalcoholic fatty liver disease, cardiovascular disease, chronic kidney disease and diabetes mellitus type 2. NAFLD: Nonalcoholic fatty liver disease; RAAS: Renin-angiotensin-aldosterone system.Many studies
hyperandrogenism 52614 most common endocrine disorders. The most important feature of PCOS is clinical and/or laboratorial hyperandrogenism . Hyperinsulinemia is very common amongst women with PCOS. Insulin and luteinizing hormone act synergistically,
hyperuricemia 30203 higher hemostatic and plasma factors, lower circulating insulin-like growth factor-1 (IGF-1) levels, hyperuricemia , oxidative stress biomarkers and endothelial dysfunction. Recent studies have shown a correlation between
metabolic syndrome 393 fatty liver disease (NAFLD) is one of the most common comorbidities associated with overweight and metabolic syndrome (MetS). Importantly, NAFLD is one of its most dangerous complications because it can lead to severe
metabolic syndrome 2020 specialists and primary care physicians.Core tip: Given the increasing worldwide incidence of obesity and metabolic syndrome , non-alcoholic fatty liver disease (NAFLD) has become the most common cause of chronic liver disease.
metabolic syndrome 2757 incidence of nonalcoholic fatty liver disease (NAFLD) is increasing along with that of obesity and metabolic syndrome (MetS). Therefore, NAFLD is the most frequent form of chronic liver disease that is closely related
metabolic syndrome 8468 of medications (anti-hyperglycemic, antihypertensive, lipid-lowering, or anti-platelet drugs), and metabolic syndrome NAFLD was independently associated with increased risk of nonfatal CVD events and CVD mortalityHamaguch
metabolic syndrome 12686 with MetS in 48% of the cases. In the same paper, IMT values were strongly related to the number of metabolic syndrome factors.In a study by Targher et al[[38]]; the severity of liver histology in NAFLD is strongly correlated
obesity 638 including fibrosis, cirrhosis and hepatic cellular carcinoma. Given the increasing worldwide prevalence of obesity , NAFLD has become the most common cause of chronic liver disease and therefore is a major global health
obesity 2008 (sub-) specialists and primary care physicians.Core tip: Given the increasing worldwide incidence of obesity and metabolic syndrome, non-alcoholic fatty liver disease (NAFLD) has become the most common cause of
obesity 2745 time.INTRODUCTIONThe overall incidence of nonalcoholic fatty liver disease (NAFLD) is increasing along with that of obesity and metabolic syndrome (MetS). Therefore, NAFLD is the most frequent form of chronic liver disease that
obesity 2962 closely related to MetS and its individual components [diabetes mellitus type 2 (T2DM), dyslipidemia, obesity and arterial hypertension]. NAFLD is diagnosed in people who do not have a history of excessive urination,
obesity 4970 although the risk factors are well established, the incidence of CVD is still increasing. Abdominal obesity , arterial hypertension, T2DM and dyslipidemia are all features of MetS and have been repeatedly found
obesity 5485 increased risk for CVD because the common risk factors are shared[[7]-[9]]. Along with the epidemic of obesity , the prevalence of MetS and NAFLD is increasing globally and is emerging as a major public health problem.Several
obesity 15276 diastolic dysfunction. Goland et al[[62]] were the first to report that NAFLD patients, in the absence of obesity , hypertension, and T2DM, have altered LV geometry and features of LV diastolic dysfunction. Fallo et
obesity 17683 abnormal adipokine profile, as shown in Figure 1[[12]].Figure 1Pathophysiological mechanisms linking obesity , nonalcoholic fatty liver disease, cardiovascular disease, chronic kidney disease and diabetes mellitus
obesity 22318 responds to physiological insulin concentrations, generally as a result of chronic hypernutrition and obesity . Hepatic IR, in addition to chronic dyslipidemia, appears to be a key underlying mechanism of NAFLD[[93]].
obesity 24482 patients[[107]]. Consistently with the “multiple hit” theory, additional risk factors, such as obesity , poor glycemic control and age, are associated with development of NAFLD in individuals with T1DM[[108]].A
obesity 26245 increased in these patients.A second factor that contributes to the aggravation of NAFLD in T2DM is obesity -induced chronic systemic inflammation, which originates in visceral adipose tissue[[113]]. When adipocytes
obesity 26740 activating the local immune system and driving a sterile inflammatory response in adipose tissue[[116]]. As obesity progresses, adipose tissue inflammation is aggravated, ultimately leading to the release of pro-inflammatory
obesity 29194 strategies. There are many well-known risk factors that contribute to the progression of CKD, such as obesity , arterial hypertension, and T2DM. Recognizing groups of patients at risk for CKD is a clinical challenge.
obesity 37195 to the development of CKD. Obesity is a known independent risk factor for CKD. Similarly, MetS and obesity have been described as strong predictors for the development of NAFLD[[121]]. The secretion of numerous
obesity 41917 The prevalence of NAFLD is continuously increasing in concert with the epidemic of its risk factors: obesity and MetS and its individual components. The increase in simultaneous liver-kidney transplantation as
obesity 47858 involvement. Moreover, psoriasis is linked with MetS: cardiometabolic risk factors (e.g., hypertension, obesity , T2DM and dyslipidemia) are more common in patients with psoriasis than in the general population, thus
obesity 49770 subchronic inflammatory state may serve as the connection between NAFLD and psoriasis. Psoriasis and obesity are directly related; psoriasis predicts the development of obesity and MetS. Therefore, NAFLD and psoriasis
obesity 49838 NAFLD and psoriasis. Psoriasis and obesity are directly related; psoriasis predicts the development of obesity and MetS. Therefore, NAFLD and psoriasis may be linked by obesity itself, which may contribute to the
obesity 49904 psoriasis predicts the development of obesity and MetS. Therefore, NAFLD and psoriasis may be linked by obesity itself, which may contribute to the development of further MetS components and comorbidities. Consistently
obesity 57790 arterial blood pressure, lipid profile determination, body weight measurement and determination of central obesity would be good screening methods for CVD. Additionally, information on smoking history and physical activity
obesity 58150 factors, such as positive family history, smoking, alcohol consumption, and the presence of T2DM and obesity , as well as frequent colon symptom analysis[[2],[4]].In summary, NAFLD is a disease that extends beyond

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