The emerging role of apolipoprotein C-III: beyond effects on triglyceride metabolism

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Term Occurence Count Dictionary
diabetes mellitus 2 endocrinologydiseases
fenofibrate 1 endocrinologydiseasesdrugs
hypertriglyceridemia 2 endocrinologydiseases
type 1 diabetes mellitus 1 endocrinologydiseases

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Select Drug Character Offset Drug Term Instance
fenofibrate 988 important risk factor for cardiovascular disease (CVD) for a long time, but randomized controlled trials of fenofibrate and omega-3 fatty acids to reduce TG failed to show any significant clinical benefits [[1], [2]]. Although
Select Disease Character Offset Disease Term Instance
diabetes mellitus 14368 a novel mechanism for HDL dysfunction.Evidence from basic experimentsDiabetes mellitusPatients with diabetes mellitus often display abnormal lipid profiles and are susceptible to CVD. Elevated glucose can upregulate apoCIII
diabetes mellitus 15308 supported by another study carried on a special animal model diabetes-prone BB rat, which develops type 1 diabetes mellitus (T1DM) at around the age of 60 days spontaneously [[30]]. Of note, antisense treatment to decrease
hypertriglyceridemia 391 referred to as an important participant in the metabolism of triglyceride-rich lipoproteins, leading to hypertriglyceridemia and thereafter cardiovascular disease. Accumulating evidence indicates that apolipoprotein C-III is
hypertriglyceridemia 1988 lipoproteins (TRLs) such as chylomicrons (CM) and very low density lipoprotein (VLDL) [[6]]. ApoCIII promotes hypertriglyceridemia (HTG) via different mechanisms. First, apoCIII inhibits the activity of lipoprotein lipase (LPL) and
type 1 diabetes mellitus 15301 supported by another study carried on a special animal model diabetes-prone BB rat, which develops type 1 diabetes mellitus (T1DM) at around the age of 60 days spontaneously [[30]]. Of note, antisense treatment to decrease

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