Non-Classical Congenital Adrenal Hyperplasia in Childhood.

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Term Occurence Count Dictionary
polycystic ovary syndrome 1 endocrinologydiseases
spironolactone 1 endocrinologydiseasesdrugs
testosterone 3 endocrinologydiseasesdrugs
cortisol 23 endocrinologydiseasesdrugs
dexamethasone 1 endocrinologydiseasesdrugs
hyperandrogenism 4 endocrinologydiseases
hyperthyroidism 1 endocrinologydiseases
obesity 1 endocrinologydiseases

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Select Drug Character Offset Drug Term Instance
cortisol 1027 group of diseases which develop as a result of deficiency of enzymes or cofactor proteins required for cortisol biosynthesis ([1],[2],[3],[4],[5]). Due to cortisol deficiency, feedback control mechanism at hypothalamic
cortisol 1079 deficiency of enzymes or cofactor proteins required for cortisol biosynthesis ([1],[2],[3],[4],[5]). Due to cortisol deficiency, feedback control mechanism at hypothalamic and hypophyseal levels remains unsatisfactory,
cortisol 3115 age ([10]). Increased androgen levels constitute the main basis of the clinical symptoms, but mild cortisol deficiency can also occur in some cases. Clinical findings include labial adhesion, perianal hair, clitoromegaly,
cortisol 9106 studies ([37]). However, some authors suggest that 12 ng/mL should be the cut-off limit ([5]). A 21-deoxy cortisol value in addition to 60th minute 17-OHP level with ACTH test for late-onset 21-OHD being exceeding 400
cortisol 9438 Furthermore, total and free testosterone levels and the levels of sex hormone-binding globulin (SHBG), cortisol , and 11-deoxycortisol should be measured at baseline and at the 60th minute. Generally, the value of
cortisol 9460 free testosterone levels and the levels of sex hormone-binding globulin (SHBG), cortisol, and 11-deoxy cortisol should be measured at baseline and at the 60th minute. Generally, the value of 60th minute cortisol
cortisol 9560 11-deoxycortisol should be measured at baseline and at the 60th minute. Generally, the value of 60th minute cortisol with ACTH test is expected to be >18 mg/dL. However, it is also important to detect the cases below
cortisol 9715 However, it is also important to detect the cases below this limit. Stoupa et al ([39]) reported that cortisol values measured in the ACTH test were below 18 mg/dL in 60% of 47 children with late-onset 21-OHD. If
cortisol 9830 measured in the ACTH test were below 18 mg/dL in 60% of 47 children with late-onset 21-OHD. If the cortisol level remains below 18 mg/dL, it should be noted that these cases may be under risk of adrenal deficiency
cortisol 10013 under risk of adrenal deficiency in stress situations.Non-classical 11b-HSD deficiency:Basal 11-deoxy cortisol level is over 10 ng/mL in late-onset 11-OH deficiency ([40]). According to Reisch et al ([40]), cut-off
cortisol 10148 late-onset 11-OH deficiency ([40]). According to Reisch et al ([40]), cut-off values for basal deoxy cortisol level are 6.95 ng/mL and 7.23 ng/mL for prepubertal and pubertal cases, respectively. When 60th minute
cortisol 10268 6.95 ng/mL and 7.23 ng/mL for prepubertal and pubertal cases, respectively. When 60th minute 11-deoxy cortisol level is higher than 18 ng/mL in the ACTH test, the diagnosis becomes definitive ([5]).Non-classical
cortisol 10524 criteria for diagnosis consist of a basal 17-OH pregnenolone level above 30 ng/mL and a 17-OH pregnenolone/ cortisol ratio above 10 SD ([5]). In girls with oligomenorrhea, anti-Müllerian hormone (AMH) increase may be
cortisol 11316 about diagnostic criteria is the measurement methods. Around the world in general, 17-OHP and 11-deoxy cortisol levels are usually measured by immunoassay [radioimmunoassay (RIA), immunochemiluminometric assay (ICMA),
cortisol 12712 normal value is 63-279 mg/24 hours), pregnanetriol (PT, normal value is 179-992 mg/24 hours), 21-deoxy cortisol metabolite pregnanetriolone (PTN, normal value is 3.5-50 mg /24 hours) ([44]). In addition to these
cortisol 13807 using urinary steroid profile and genetic studies ([45]). Another point to be noted is that 11-deoxy cortisol and cortisol demonstrate a cross-reactivity with a rate of 23.3% among measurement methods. Thus, Xu
cortisol 13820 steroid profile and genetic studies ([45]). Another point to be noted is that 11-deoxycortisol and cortisol demonstrate a cross-reactivity with a rate of 23.3% among measurement methods. Thus, Xu et al ([46])
cortisol 13975 23.3% among measurement methods. Thus, Xu et al ([46]) reported that the level of Immulite 2000 and cortisol can be false-low, whereas 11-deoxycortisol level can be false-high.Genetic StudiesGenetic studies in
cortisol 14018 et al ([46]) reported that the level of Immulite 2000 and cortisol can be false-low, whereas 11-deoxy cortisol level can be false-high.Genetic StudiesGenetic studies in classical and non-classical CAH cases are
cortisol 16369 age. A second indication for starting treatment with hydrocortisone depends on the finding that the cortisol level measured at the 60th minute of the ACTH test does not exceed 18 mg/dL ([54]).Another issue is
cortisol 17531 ([2]). This is because the increasing IGF-1 level decreases 11-b OHSD type-1 activity and also increases cortisol clearance due to increase in glomerular filtration rate. Adrenal would be suppressed with the administration
cortisol 18531 hydrocortisone is discontinued and normal development of pubertal height is ensured ([2]). If peak cortisol level of pubertal and adult females measured after ACTH is below 18 mg/dL, steroid treatment is administered
cortisol 18888 levothyroxine or hyperthyroidism occurs, adrenal crisis may arise as the result of increased clearance of cortisol ([57]). In cases with hirsutism, treatment with oral contraceptive agents leads to an increase in SHBG
dexamethasone 18136 hypothalamic-pituitary-adrenal axis. If hyperandrogenism findings are clear, administering 0.25 mg of dexamethasone at night is recommended ([54]). Some clinicians suggest that hydrocortisone treatment should be continued
spironolactone 19171 ovary, and consequently to improvement in menstrual irregularity ([14]). If necessary, anti-androgens ( spironolactone , flutamide, cyproterone acetate, or finasteride) may be added to the treatment. Cosmetic approaches
testosterone 9363 and corticotropin-releasing hormone (CRH) are not high in these cases. Furthermore, total and free testosterone levels and the levels of sex hormone-binding globulin (SHBG), cortisol, and 11-deoxycortisol should
testosterone 11971 LC-MS/MS methods in 39 females with hyperandrogenism presentation and 29 females in a control group. Total testosterone , dehydroepiandrosterone sulfate (DHEA-S), androstenedione, and 17-OHP were measured with immunoassay
testosterone 21294 ACTH stimulation. These tumors are hypoechoic and smooth marginated. Infertility occurs as a result of testosterone production deficiency and oligospermia as a result of mass compression. Therefore, periodic testis ultrasonograhic
Select Disease Character Offset Disease Term Instance
hyperandrogenism 11900 study in which hormone levels were measured by immunoassay and LC-MS/MS methods in 39 females with hyperandrogenism presentation and 29 females in a control group. Total testosterone, dehydroepiandrosterone sulfate (DHEA-S),
hyperandrogenism 12970 steroid metabolite studies and genetic tests on 40 adult female patients (age range of 18-39 years) with hyperandrogenism presentation. An ACTH test was conducted in patients with a basal 17-OHP level of 1.7-10 ng/mL. The
hyperandrogenism 17921 hydrocortisone treatment reach adolescence, the treatment can be ended if there are no findings of hyperandrogenism such as hirsutism, acne, and oligomenorrhea. At this time, an ACTH test is also done to control hypothalamic-pituitary-adrenal
hyperandrogenism 18074 oligomenorrhea. At this time, an ACTH test is also done to control hypothalamic-pituitary-adrenal axis. If hyperandrogenism findings are clear, administering 0.25 mg of dexamethasone at night is recommended ([54]). Some clinicians
hyperthyroidism 18799 adrenomedullary functions does not occur in these cases ([56]). However, if an increase in levothyroxine or hyperthyroidism occurs, adrenal crisis may arise as the result of increased clearance of cortisol ([57]). In cases with
obesity 20688 psychiatric problems (psychosis, suicide, alcohol use, drug use), decrease in bone density, fractures, obesity , dyslipidemia, insulin resistance, diabetes, increase in the thickness of intima media, hypertension,
polycystic ovary syndrome 4728 was detected in 4.7% of the 126 subjects (122 girls, 4 boys) with premature pubarche, hirsutism, or polycystic ovary syndrome (PCOS) presentation ([20]). Increased penile length can be observed among boys. Prepubertal gynecomastia

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