'Browning' the cardiac and peri-vascular adipose tissues to modulate cardiovascular risk

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Annotation Summary

Term Occurence Count Dictionary
obesity 11 endocrinologydiseases
Exenatide 1 endocrinologydiseasesdrugs
hyperlipidemia 1 endocrinologydiseases
hypertriglyceridemia 1 endocrinologydiseases
metabolic syndrome 3 endocrinologydiseases

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Select Drug Character Offset Drug Term Instance
Exenatide 25947 cardiac and vascular adipose tissues by pharmacological means.Glucagon-like peptide 1 (GLP-1) agonists Exenatide and Liraglitude are currently in clinical use for the management of hyperglycaemia in type 2 diabetes.
Select Disease Character Offset Disease Term Instance
hyperlipidemia 17291 evidence for a beneficial role of BAT from rodent studies demonstrates that its activation corrects hyperlipidemia [80], reduces hypercholesterolemia and protects from the development of atherosclerosis [81]. Transplantation
hypertriglyceridemia 9073 EAT may also contribute to the uptake of intravascular FFA and protect the coronary vasculature from hypertriglyceridemia associated damage. Furthermore the distribution of putatively thermogenic EAT around the coronary arteries
metabolic syndrome 2131 adiposity is a major independent risk factor for cardiovascular disease (CVD) [1], [2] and the associated metabolic syndrome . Pathological changes in white adipose tissue with obesity directly contribute to both metabolic abnormalities
metabolic syndrome 10552 and CVD risk4Despite Mazur et al. [46] stating in 2010 that EAT is not an independent predictor of metabolic syndrome in children and adolescents and that the prognostic value of this tissue may differ comparative to the
metabolic syndrome 10853 echocardiography demonstrates a clear direct relationship between EAT and CVD risk. In obese adolescents with metabolic syndrome EAT thickness (EATT) was raised and positively correlated with fasting plasma glucose and triglycerides,
obesity 1258 composed of brown adipose tissue in the healthy state and undergo a brown-to-white transition i.e. during obesity which may be a driving factor of cardiovascular disease. In this review we discuss the risks of excess
obesity 2201 (CVD) [1], [2] and the associated metabolic syndrome. Pathological changes in white adipose tissue with obesity directly contribute to both metabolic abnormalities and the atherosclerotic process [3], [4]. Visceral
obesity 2793 and dissipate chemical energy as heat [5]. In humans reduced BAT function is closely associated with obesity , compromised metabolic health and cardiovascular risk [6], [7], [8]. The activation of existing BAT,
obesity 9558 vascular tone, remodelling and endothelial function [39]. Under pathophysiological conditions such as obesity PVAT becomes dysfunctional and compared to subcutaneous and other visceral depots expresses a higher
obesity 11270 were shown by Boyraz et al. [48] who further divided the obese group into mild–moderate and severe obesity where EAT was only positively correlated with the majority of metabolic and clinical parameters in the
obesity 14610 tissue dysfunction and a pro-inflammatory phenotype [60]. Similar to white adipocytes with the onset of obesity , multilocular lipid droplets in BAT accumulate lipid becoming hypertrophic and outstrip the vascular
obesity 15251 [21], [33]. It could be hypothesised that further whitening of cardiac and vascular adipose tissues in obesity and the subsequent dysfunction that occurs could drive a hypoxic, inflammatory microenvironment affecting
obesity 16562 postulated that increasing brown and/or beige adipose mass and activity is a feasible target to prevent obesity and related cardiometabolic disease [68], [69]. Adult humans retain significant amounts of metabolically
obesity 20761 dams demonstrates that there is a diminished anti-contractile effect of PVAT occurring prior to both obesity and hypertension [92]. These studies highlight the importance of maternal nutrient status as it has
obesity 36749 cardiac and perivascular adipose tissues are phenotypically brown early in life but whiten with age and obesity , becoming dysfunctional and contributing to atherogenesis in the local vasculature. Whilst active BAT
obesity 38529 1Fig. 2Summary figure. In the healthy state cardiac and vascular adipose tissues resemble BAT. During obesity these tissues become hypertrophic, inflammatory and dysfunctional driving endothelial dysfunction and

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