A Different Perspective for Management of Diabetes Mellitus: Controlling Viral Liver Diseases

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Term Occurence Count Dictionary
metformin 1 endocrinologydiseasesdrugs
obesity 4 endocrinologydiseases
type 1 diabetes mellitus 1 endocrinologydiseases
type 2 diabetes mellitus 1 endocrinologydiseases
Insulin 2 endocrinologydiseasesdrugs
diabetes mellitus 4 endocrinologydiseases
diabetic ketoacidosis 1 endocrinologydiseases
hyperinsulinemia 1 endocrinologydiseases
glucose intolerance 1 endocrinologydiseases
hyperuricemia 1 endocrinologydiseases
metabolic syndrome 1 endocrinologydiseases

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Select Drug Character Offset Drug Term Instance
Insulin 944 liver diseases to give an update of the management of DM rooted by viral liver diseases.1. Introduction Insulin deficiency and/or insulin resistance, which causes glycometabolism disorders, leads to the symptoms
Insulin 18438 insulin-like growth factor IGF-1 and is directly involved in carcinogenesis by acting on cancer cells. Insulin decreases the expression of IGF binding protein-1, thus increasing the bioactive IGF-1. In contrast
metformin 10534 [[49]].With or without cirrhosis, DM reduces SVR [[7]]. In a different study, researchers claim that a mix of metformin , pegylated interferon, and ribavirin prolonged the SVR and increased insulin sensitivity only in women
Select Disease Character Offset Disease Term Instance
diabetes mellitus 432 ChinaPublication date (ppub): /2017Publication date (epub): 3/2017AbstractKnowing how to prevent and treat diabetes mellitus (DM) earlier is essential to improving outcomes. Through participating in synthesis and catabolism of
diabetes mellitus 1055 deficiency and/or insulin resistance, which causes glycometabolism disorders, leads to the symptoms of diabetes mellitus (DM). DM is an increasingly recognized global health concern. By 2030, the prevalence of diabetes among
diabetes mellitus 3261 (NAFLD), fatty liver, cirrhosis, and hepatocellular carcinoma (HCC), have high comorbidity of type 2 diabetes mellitus (T2DM) [[4], [5]]. Many studies have proposed that liver-injury patients are likely to have a greater
diabetes mellitus 9757 CHC patients with interferon (INF) treatment had a greater (10–18-fold) danger of developing type 1 diabetes mellitus (T1DM) than the common population, with a median onset age of 43 (range: 24–66 years) in Caucasians
diabetic ketoacidosis 1632 hearts, and blood vessels. Serious illness or stress can result in acute metabolic disorders, such as diabetic ketoacidosis (DKA) and hyperglycemic hyperosmolar status. Recently, some studies suggested that diabetes heightens
glucose intolerance 11784 age, gender, BMI, and cirrhosis [[54]].3.3. MechanismsThrough increasing oxidative stress, IR, and glucose intolerance , HCV results in hyperuricemia, arterial hypertension, and atherosclerosis, thus damaging the cardiovascular
hyperinsulinemia 17834 two-year follow-up after SVR. As time went on, the risk declined [[69]].Systemic risks of HCC, such as hyperinsulinemia , obesity-related hypoxia, systemic inflammation, systemic influences of cytokines and adipokines, systemic
hyperuricemia 11820 [[54]].3.3. MechanismsThrough increasing oxidative stress, IR, and glucose intolerance, HCV results in hyperuricemia , arterial hypertension, and atherosclerosis, thus damaging the cardiovascular system [[57]]. HCV likely
metabolic syndrome 23139 treatment [[76]]. Actively intervening with these risk factors could decrease the occurrence rate of metabolic syndrome after liver transplantation and improve the patient's quality of life [[77]].7. SummaryDM is constantly
obesity 17852 after SVR. As time went on, the risk declined [[69]].Systemic risks of HCC, such as hyperinsulinemia, obesity -related hypoxia, systemic inflammation, systemic influences of cytokines and adipokines, systemic immune
obesity 19069 Higher leptin and lower adiponectin levels could also increase the risk of cancer in patients with obesity or T2DM. The lasting action of inflammatory cytokines would interrupt the normal capacity for intracellular
obesity 21533 survival rate, such as the development of de novo malignancies, recurrence of underlying diseases, obesity , hypertension, new-onset diabetes, dyslipidemia, and cardiovascular diseases [[74]]. A common complication
obesity 22224 factors for post-LT NODAT. In Western countries, the three major risk factors of NODAT are HCV infection, obesity , and alcoholic cirrhosis. The major risk factor in China is viral hepatitis [[74]–[76]].6.3. MechanismsThe
type 1 diabetes mellitus 9750 that CHC patients with interferon (INF) treatment had a greater (10–18-fold) danger of developing type 1 diabetes mellitus (T1DM) than the common population, with a median onset age of 43 (range: 24–66 years) in Caucasians
type 2 diabetes mellitus 3254 disease (NAFLD), fatty liver, cirrhosis, and hepatocellular carcinoma (HCC), have high comorbidity of type 2 diabetes mellitus (T2DM) [[4], [5]]. Many studies have proposed that liver-injury patients are likely to have a greater

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