Changes of Regulatory T Cells and of Proinflammatory and Immunosuppressive Cytokines in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis.

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Term Occurence Count Dictionary
diabetes mellitus 11 endocrinologydiseases
hyperglycemia 2 endocrinologydiseases
type 2 diabetes mellitus 2 endocrinologydiseases

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diabetes mellitus 1006 transforming growth factor-β (TGF-β), and tumor necrosis factor-alpha (TNF-α) in patients with type 2 diabetes mellitus (T2DM). Methods. We performed a comprehensive search up to July 2016 for all clinical studies about
diabetes mellitus 2170 diabetic complications further lowers the peripheral CD4+CD25+Foxp3+Treg number.1. IntroductionType 2 diabetes mellitus (T2DM) is one of the most common noncommunicable diseases characterized by insulin resistance and impaired
diabetes mellitus 6165 T cells” or “Treg” or “CD4+CD25+ T cell” or “CD4+CD25+Foxp3+ T cell”) and (“type 2 diabetes mellitus ” or “type 2 diabetes” or “diabetes mellitus” or “diabetic patients” or “T2DM” or “DM”).
diabetes mellitus 6217 or “CD4+CD25+Foxp3+ T cell”) and (“type 2 diabetes mellitus” or “type 2 diabetes” or “ diabetes mellitus ” or “diabetic patients” or “T2DM” or “DM”). In addition, we also conducted an extensive
diabetes mellitus 22960 [[44]]2015China4820/2816.178.362013/75.22.038Daniele [[45]]2014USA1713/42.10.4157/81.70.48Głowińska [[46]]2003Polish28NR6.51.415NR2.32.37DM: diabetes mellitus ; SZ: sample size; M/F: man/female; SD: standard deviation; NR: not reported. ∗T2DM with complication
diabetes mellitus 25627 [[67]]2005China30NR136.621.4530NR29.410.628Zhou∗∗ [[67]]2005China30NR79.6315.9630NR29.410.628DM: diabetes mellitus ; SZ: sample size; M/F: man/female; SD: standard deviation; NR: not reported. ∗,∗∗T2DM with different
diabetes mellitus 26448 [[38]]2014Serbia30NR1.530.4215NR0.710.38Lukic∗ [[38]]2014Serbia30NR1.540.4115NR0.710.38Daniele [[45]]2014USA1713/42.50.3157/81.50.37DM: diabetes mellitus ; SZ: sample size; M/F: man/female; SD: standard deviation; NR: not reported. ∗T2DM with complication
diabetes mellitus 27178 [[73]]2009China6033/273.27331.5835158/73.62160.69388Zhang [[74]]2009China179/85.023.59158/75.073.267Zhang [[75]]2012China1611/52.210.92197/122.320.66DM: diabetes mellitus ; SZ: sample size; M/F: man/female; SD: standard deviation; NR: not reported. ∗,∗∗T2DM with different
diabetes mellitus 28533 [[90]]2014China5026/248.391.185024/2617.631.228Zhao-Hui∗ [[90]]2014China5028/221.860.335024/2617.631.228DM: diabetes mellitus ; SZ: sample size: M/F: man/female; SD: standard deviation; NR: not reported. ∗T2DM with complication.Table
diabetes mellitus 30112 [[104]]2013China3619/178.83.62011/912.41.57Zhang∗ [[104]]2013China3016/146.051.062011/912.41.57DM: diabetes mellitus ; SZ: sample size; M/F: man/female; SD: standard deviation; NR: not reported. ∗,∗∗T2DM with different
diabetes mellitus 31248 [[114]]2015India6538/2759.82.88835/5394.712.756Vasanthakumar∗c [[114]]2015India9757/4067.42.2758835/5394.712.756DM: diabetes mellitus ; SZ: sample size; M/F: man/female; SD: standard deviation; NR: not reported. ∗T2DM with complication;
hyperglycemia 2378 resistance and impaired insulin secretion [[1], [2]]. Metabolic proinflammatory disorder including chronic hyperglycemia and increased levels of circulating cytokines suggests immunological disturbances [[3]–[7]], which
hyperglycemia 17975 microalbuminuria and overt proteinuria [[137]]. Additionally, elevated plasma TGF-β may reflect the state of hyperglycemia in T2DM patients [[48]]. Systemic inflammation in T2DM is linked to the development of diabetic complications
type 2 diabetes mellitus 999 IL-10, transforming growth factor-β (TGF-β), and tumor necrosis factor-alpha (TNF-α) in patients with type 2 diabetes mellitus (T2DM). Methods. We performed a comprehensive search up to July 2016 for all clinical studies about
type 2 diabetes mellitus 6158 (“regulatory T cells” or “Treg” or “CD4+CD25+ T cell” or “CD4+CD25+Foxp3+ T cell”) and (“ type 2 diabetes mellitus ” or “type 2 diabetes” or “diabetes mellitus” or “diabetic patients” or “T2DM” or “DM”).

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