Combatting type 2 diabetes by turning up the heat.

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Term Occurence Count Dictionary
diabetes mellitus 5 endocrinologydiseases
metabolic syndrome 1 endocrinologydiseases
metformin 1 endocrinologydiseasesdrugs
obesity 9 endocrinologydiseases
type 2 diabetes mellitus 5 endocrinologydiseases

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Select Drug Character Offset Drug Term Instance
metformin 19587 approaches for treating/preventing diabetes. In fact, the most widely prescribed glucose-lowering drug, metformin , has been suggested to work via the induction of energy stress in the cell and thereby activation of
Select Disease Character Offset Disease Term Instance
diabetes mellitus 538 increase energy metabolism and are considered to be among the best strategies for prevention of type 2 diabetes mellitus . More recently, cold exposure has been suggested to have a therapeutic value in type 2 diabetes. At
diabetes mellitus 1435 available to authorised users.IntroductionObesity is the major risk factor for the development of type 2 diabetes mellitus . It is not only characterised by an increased storage of fat in subcutaneous white adipose tissue but
diabetes mellitus 4406 cold exposure can offset obesity-related insulin resistance and be a preventive strategy for type 2 diabetes mellitus .Defining components of human energy metabolismHeat productionIn the (human) body, almost all energy
diabetes mellitus 19399 explanation for how boosting energy turnover could be beneficial for the prevention and treatment of type 2 diabetes mellitus . They are also direct targets for pharmacological and nutritional approaches for treating/preventing
diabetes mellitus 36505 mild cold exposure provide strong intervention strategies for the prevention and treatment of type 2 diabetes mellitus .Electronic supplementary materialBelow is the link to the electronic supplementary material.Electronic
metabolic syndrome 3676 on many metabolism-related diseases such as type 2 diabetes [[4]], cardiovascular disease [[5]], the metabolic syndrome [[6]] and even cancer [[7]]. This notion is underscored further by the recent evidence that breaking
obesity 2983 after an 8 month training period [[3]]. Consequently, over recent decades most of the research in the obesity field has focused on reducing energy intake to combat obesity and type 2 diabetes, and the role of energy
obesity 3045 recent decades most of the research in the obesity field has focused on reducing energy intake to combat obesity and type 2 diabetes, and the role of energy expenditure in metabolic health has been underappreciated
obesity 3307 increasingly evident that enhancing energy metabolism per se can counterbalance the metabolic consequences of obesity and that increasing energy turnover is an important target in the prevention of obesity-related metabolic
obesity 3395 consequences of obesity and that increasing energy turnover is an important target in the prevention of obesity -related metabolic disturbances, such as insulin resistance. For example, even though exercise has only
obesity 4331 intervention studies, suggesting that increasing energy turnover by exercise and/or cold exposure can offset obesity -related insulin resistance and be a preventive strategy for type 2 diabetes mellitus.Defining components
obesity 9063 by other means [[24]]. Indeed, a low RMR has been shown to be a risk factor for the development of obesity [[25]]. Nevertheless, most intervention studies in which energy expenditure is elevated do show beneficial
obesity 13078 ectopic fat and insulin sensitivityAthlete’s paradoxAs outlined above, one of the major determinants of obesity -associated metabolic complications is the location of the storage of excess fat, with fat accumulation
obesity 17681 circulating fatty acids and triacylglycerols. However, chronic oversupply of fat to the liver, such as in obesity , leads to hepatic steatosis, increased VLDL-triacylglycerol production, hepatic insulin resistance and
obesity 24065 and cholesterol levels and on postprandial lipid metabolism, important factors in the development of obesity -related metabolic complications [[78]]. Interestingly, also in the liver a reduced energy metabolism
type 2 diabetes mellitus 531 training increase energy metabolism and are considered to be among the best strategies for prevention of type 2 diabetes mellitus . More recently, cold exposure has been suggested to have a therapeutic value in type 2 diabetes. At
type 2 diabetes mellitus 1428 is available to authorised users.IntroductionObesity is the major risk factor for the development of type 2 diabetes mellitus . It is not only characterised by an increased storage of fat in subcutaneous white adipose tissue but
type 2 diabetes mellitus 4399 and/or cold exposure can offset obesity-related insulin resistance and be a preventive strategy for type 2 diabetes mellitus .Defining components of human energy metabolismHeat productionIn the (human) body, almost all energy
type 2 diabetes mellitus 19392 explanation for how boosting energy turnover could be beneficial for the prevention and treatment of type 2 diabetes mellitus . They are also direct targets for pharmacological and nutritional approaches for treating/preventing
type 2 diabetes mellitus 36498 exercise and mild cold exposure provide strong intervention strategies for the prevention and treatment of type 2 diabetes mellitus .Electronic supplementary materialBelow is the link to the electronic supplementary material.Electronic

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