Is islet transplantation a realistic approach to curing diabetes?

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Term Occurence Count Dictionary
Insulin 1 endocrinologydiseasesdrugs
diabetes mellitus 1 endocrinologydiseases
hypoglycemia 15 endocrinologydiseases
type 1 diabetes mellitus 1 endocrinologydiseases

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Select Drug Character Offset Drug Term Instance
Insulin 11543 outcome of islet and pancreas whole organ transplantationIslet transplantationPancreas transplantation Insulin independence rate25%–50% at 5 years in international cohort studies (~50% in some experienced centers
Select Disease Character Offset Disease Term Instance
diabetes mellitus 1345 1-year insulin independence following pancreatic islet transplantation in seven consecutive type 1 diabetes mellitus patients [[1]], the position of islet transplantation in clinical medicine has been reappraised [[2]-[5]].
hypoglycemia 777 is now transitioning from an experimental to a proven therapy for type 1 diabetes with problematic hypoglycemia . Islet autotransplantation has already been therapeutically proven in chronic pancreatitis with severe
hypoglycemia 3207 independence by pancreatic islet transplantation in seven consecutive type 1 diabetes patients with severe hypoglycemia and intact renal function. The subsequent international clinical trial of the landmark “Edmonton protocol”
hypoglycemia 3487 rate of maintaining glycated hemoglobin (HbA1c) levels at less than 7.0% for 5 years without severe hypoglycemia [[11]]. Although the single-donor insulin-independence rate of allogeneic islet transplantation is still
hypoglycemia 3762 with only a few exceptions in some experienced centers [[12]], the rates of protection from severe hypoglycemia associated with the allogeneic transplantation of islets or of the whole pancreas are comparable [[13]].
hypoglycemia 4114 allogeneic islet transplantation, islet and pancreas transplantation are equally effective in curing severe hypoglycemia , achieving a success rate of about 70% after more than 5 years. Moreover, the success rate of islet
hypoglycemia 4546 (Table 1). Therefore, the latest treatment regimen for patients with type 1 diabetes and problematic hypoglycemia recommends islet or pancreas transplantation for patients with continuing severe hypoglycemia as the
hypoglycemia 4640 problematic hypoglycemia recommends islet or pancreas transplantation for patients with continuing severe hypoglycemia as the final component in a stepwise approach that includes structured education regarding multiple
hypoglycemia 5088 terms of the graft survival rate (~80%), with a 58% rate of HbA1c levels at < 7% and lack of severe hypoglycemia 5 years after islet transplantation [[14]]. Several cases of partial islet graft function have also
hypoglycemia 5927 allogeneic islet transplantation as a proven rather than just an experimental therapy for problematic hypoglycemia and may provide a basis for U.S. Food and Drug Administration approval in the near future. The results
hypoglycemia 6201 reimbursement for clinical allogeneic islet transplantation in patients with type 1 diabetes and problematic hypoglycemia .Additionally, the clinical outcomes achieved in selected centers with extensive experience are already
hypoglycemia 7002 trial indicate that allogeneic islet transplantation can offer freedom from life-threatening severe hypoglycemia for type 1 diabetes patients with problematic hypoglycemia, even in non-responders to the latest technology-based
hypoglycemia 7061 offer freedom from life-threatening severe hypoglycemia for type 1 diabetes patients with problematic hypoglycemia , even in non-responders to the latest technology-based treatments.LESSONS FROM CLINICAL ISLET AUTOTRANSPLANTATIONThe
hypoglycemia 8831 values than the control group (111 ± 4 mg/dL vs. 130 ± 13 mg/dL, p = 0.003) without increased risk of hypoglycemia (percentage of time < 70 mg/dL: 1.9% in the closed-loop insulin delivery group vs. 4.8% in the control
hypoglycemia 11028 reappraisal of this method as an important component of the stepwise approach to the treatment of problematic hypoglycemia . The 5-year insulin-independence rate of islet transplantation patients has also improved at some experienced
hypoglycemia 11742 experienced centers [[7],[12]])70% at 5 yearsGraft survival (fasting C-peptide > 0.3 ng/mL, free of severe hypoglycemia )~70% at 5 years (75% at 5 years in the French-Swiss GRAGIL group [[14]])~70% at 5 yearsSuccess rate
type 1 diabetes mellitus 1338 report of 1-year insulin independence following pancreatic islet transplantation in seven consecutive type 1 diabetes mellitus patients [[1]], the position of islet transplantation in clinical medicine has been reappraised [[2]-[5]].

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