Weight Loss and Mortality in Overweight and Obese Cancer Survivors: A Systematic Review

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obesity 949 between weight loss and mortality (cancer-specific or all-cause) in overweight/obese patients with obesity -related cancers. Where available, data from the same studies on non-overweight patients were compared.ResultsFive
obesity 2000 relevant data are within the paper and its Supporting Information files.IntroductionOverweight and obesity are highly prevalent [[1]] and associated with increased risk of a number of the most common cancers
obesity 5844 change, weight reduction), mortality (mortality, survival, death), weight status (overweight, obese, obesity , BMI), and presence of cancer (cancer, malignan*, neoplasm*, carcinoma, tumour, tumor). All fields were
obesity 8300 consider that intentional weight loss would affect outcomes in cancers with an aetiological link with obesity (e.g. endometrial or breast), but less plausible for non-obesity-related cancers (e.g. nasopharyngeal),
obesity 8365 cancers with an aetiological link with obesity (e.g. endometrial or breast), but less plausible for non- obesity -related cancers (e.g. nasopharyngeal), we also excluded studies restricted to cancer types not convincingly
obesity 8700 2014 Lancet paper [[4]]. Although some reviews provide suggestive evidence of an association between obesity and poorer survival from cancer (e.g., see [[24],[26]]), we do not believe it to be sufficient to warrant
obesity 8891 sufficient to warrant inclusion of cancer types that do not have an aetiological relationship with obesity . In a report by the World Cancer Research Fund on breast cancer survivorship, it was concluded that
obesity 9919 related to adiposity and energy metabolism to provide biological plausibility for a causal role of obesity in poorer cancer survival. Taking all of these factors into account, we did not feel that the evidence
obesity 10057 Taking all of these factors into account, we did not feel that the evidence for an association between obesity and poor survival in non-aetiologically-linked cancers was convincing enough for studies in these cancer
obesity 29985 weight loss has an overall neutral effect on survival [[63]]. In the context of breast cancer, both obesity and post-diagnostic weight gain have been shown to significantly increase the risk of mortality [[15],[64]],
obesity 32982 sources of mortality such as second cancers [[69],[70]], likely due to common risk factors such as obesity , as well as the impact of cancer treatments like anthracyclines and radiation. Weight loss has been
obesity 33535 underlie an association between weight loss and increased mortality risk.Aside from effects on mortality, obesity has also been shown to increase the risk of morbidity in women with breast cancer. Surgical complications
obesity 36098 standard BMI cut-offs (as opposed to cut-offs adapted for Asian populations) to define overweight and obesity in the Chinese samples in two of the studies may also have resulted in effects in the non-overweight

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