Expanding frontiers in weight-control research explored by young investigators

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Term Occurence Count Dictionary
metabolic syndrome 2 endocrinologydiseases
obesity 11 endocrinologydiseases
Insulin 1 endocrinologydiseasesdrugs
fenofibrate 1 endocrinologydiseasesdrugs

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Select Drug Character Offset Drug Term Instance
Insulin 15265 could ameliorate glucose dysmetabolism in HFD-fed mice via local D2R signaling in islets (Fig. 3). Insulin secretion from β-cells is mainly regulated by two distinct signaling pathways: (1) the ATP-sensitive
fenofibrate 10523 The log Po/w of γ-oryzanol has been calculated as 12.1 using the XLOGP3 method [[33]], while that of fenofibrate , one of the most lipophilic agents among the clinically-used drugs, is 5.19 [[34], [35]]. This suggests
Select Disease Character Offset Disease Term Instance
metabolic syndrome 8796 body weight and ameliorated glucose and lipid dysmetabolism compared with white rice in subjects with metabolic syndrome [[24]]. During the refining process, most of the outer parts of the grain are removed despite their
metabolic syndrome 16953 of the most severe health problems in the world [[64]]. Obesity represents a major risk factor for metabolic syndrome and is associated with type 2 diabetes, cancer, and cardiovascular disease. The current obesity epidemic
obesity 8267 food-derived factors that regulate brush cells may open new avenues for the treatment of allergic diseases, obesity , and diabetes.Impact of a brown rice-derived bioactive product on feeding regulation and fuel metabolism
obesity 8404 brown rice-derived bioactive product on feeding regulation and fuel metabolism (by Chisayo Kozuka)Anti- obesity and anti-diabetic components of brown ricePrevious studies have shown that a diet containing whole grains
obesity 9385 the composition of gut microbiota in humans [[27]]. These data suggest that brown rice ameliorates obesity and diabetes at least partly via its effect on the profile and activity of intestinal microbiota. Conversely,
obesity 9692 metabolism in either healthy or diabetic rats [[22]]. This result suggests that brown rice contains anti- obesity and anti-diabetic components other than dietary fiber. γ-oryzanol is a brown rice-specific bioactive
obesity 10941 preference for dietary fat and consequently decrease body weight gain [[36]].Feeding regulation and obesity Feeding behavior is regulated by the hypothalamus and mesolimbic reward system. The hypothalamic arcuate
obesity 11956 suggest the importance of hypothalamic inflammation and ER stress as novel therapeutic targets for obesity . In an in vitro reporter assay in HEK293 cells, γ-oryzanol significantly suppressed an ER stress inducer,
obesity 13458 allele of the DRD2/Ankyrin repeat and kinase domain containing 1 (ANKK1) gene locus is associated with obesity [[49]], while effects of weight loss after bariatric surgery are associated with elevated striatal D2R
obesity 14108 γ-oryzanol restored the expression levels (Kozuka et al. manuscript under review) (Fig. 2). Anti- obesity drugs acting on the brain reward system (e.g., rimonabant) have been developed, but most were withdrawn
obesity 16603 to fully elucidate the molecular mechanisms involved, γ-oryzanol shows potential as a treatment for obesity and diabetes.Fig. 3γ-oryzanol enhances GSIS via the inhibition of D2RA novel G protein-coupled receptor-regulated
obesity 17060 metabolic syndrome and is associated with type 2 diabetes, cancer, and cardiovascular disease. The current obesity epidemic significantly affects public health and reduces economic activity by increasing medical costs.
obesity 17346 changes and physical activity, there is a strong need for effective pharmacological strategies to stop obesity [[65]]. Unfortunately, the number and efficacy of appetite-suppressing drugs approved for clinical use

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